Rita Pereira
A5027344170- Prostate Cancer Treatment and Research
- COVID-19 Clinical Research Studies
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Respiratory Support and Mechanisms
- Long-Term Effects of COVID-19
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Glioma Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Anatomy and Medical Technology
- PARP inhibition in cancer therapy
- Liver Disease Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Ubiquitin and proteasome pathways
- Dental Research and COVID-19
- Immune cells in cancer
- Protein Degradation and Inhibitors
- DNA Repair Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Cell Adhesion Molecules Research
- Education during COVID-19 pandemic
- Angiogenesis and VEGF in Cancer
- Epigenetics and DNA Methylation
Institute of Cancer Research
2018-2025
Centro Hospitalar do Porto
2023-2025
Hospital de Santo António
2024
University of Lisbon
2024
Universidade Federal do Acre
2018-2023
Royal Marsden NHS Foundation Trust
2021-2023
National Hospital for Neurology and Neurosurgery
2023
University College London
2023
Royal Marsden Hospital
2020-2021
Centro De Medicina Veterinária Anjos De Assis
2021
BackgroundMetastatic castration-resistant prostate cancer is enriched in DNA damage response (DDR) gene aberrations. The TOPARP-B trial aims to prospectively validate the association between DDR aberrations and olaparib metastatic cancer.MethodsIn this open-label, investigator-initiated, randomised phase 2 following a selection (or pick-the-winner) design, we recruited participants from 17 UK hospitals. Men aged 18 years or older with progressing previously treated one two taxane...
Resistance to androgen receptor (AR) blockade in castration-resistant prostate cancer (CRPC) is associated with sustained AR signaling, including through alternative splicing of (AR-SV). Inhibitors transcriptional coactivators that regulate activity, the paralog histone acetyltransferase proteins p300 and CBP, are attractive therapeutic targets for lethal cancer. Herein, we validate targeting p300/CBP as a strategy describe CCS1477, novel small-molecule inhibitor conserved bromodomain. We...
Abstract PARP inhibitors are approved for treating advanced prostate cancers (APC) with various defective DNA repair genes; however, further studies to clinically qualify predictive biomarkers warranted. Herein we analyzed TOPARP-B phase II clinical trial samples, evaluating whole-exome and low-pass whole-genome sequencing IHC IF assays ATM RAD51 foci (testing homologous recombination function). BRCA1/2 germline somatic pathogenic mutations associated similar benefit from olaparib; greater...
Abstract Purpose: Circulating tumor cells (CTCs) have clinical relevance, but their study has been limited by low frequency. Experimental Design: We evaluated liquid biopsies apheresis to increase CTC yield from patients suffering metastatic prostate cancer, allow precise gene copy-number calls, and disease heterogeneity. Results: Apheresis was well tolerated allowed the separation of large numbers CTCs; average 7.5 mL peripheral blood 167 CTCs, whereas per (mean volume: 59.5 mL) 12,546...
Detection of androgen receptor splice variant-7 (AR-V7) mRNA in circulating tumour cells (CTCs) is associated with worse outcome metastatic castration-resistant prostate cancer (mCRPC). However, studies rarely report comparisons CTC counts and biopsy AR-V7 protein expression. To determine the reproducibility AdnaTest testing, associations clinical characteristics, CellSearch counts, expression overall survival (OS). status was determined for 227 peripheral blood samples, from 181 mCRPC...
Abstract It has been recognized for decades that ERBB signaling is important in prostate cancer, but targeting receptors as a therapeutic strategy cancer ineffective clinically. However, we show here membranous HER3 protein commonly highly expressed lethal associating with reduced time to castration resistance (CR) and survival. Multiplex immunofluorescence indicated the ligand NRG1 detectable primarily tumor-infiltrating myelomonocytic cells human cancer; this observation was confirmed...
Background Data suggest that immunomodulation induced by DNA hypomethylating agents can sensitize tumors to immune checkpoint inhibitors. We conducted a phase 1 dose-escalation trial ( NCT02998567 ) of guadecitabine and pembrolizumab in patients with advanced solid tumors. hypothesized will overcome resistance. Methods Patients received (45 mg/m 2 or 30 , administered subcutaneously on days 1–4), (200 mg intravenously starting from cycle onwards) every 3 weeks. Primary endpoints were safety,...
Abstract Endocrine resistance (EnR) in advanced prostate cancer is fatal. EnR can be mediated by androgen receptor (AR) splice variants, with AR variant 7 (AR-V7) arguably the most clinically important variant. In this study, we determined proteins key to generating AR-V7, validated our findings using clinical samples, and studied splicing regulatory mechanisms models. Triangulation studies identified JMJD6 as a regulator of evidenced its upregulation vitro EnR, downregulation alongside...
CD38, a druggable ectoenzyme, is involved in the generation of adenosine, which implicated tumour immune evasion. Its expression and role prostate tumour-infiltrating cells (TIICs) have not been elucidated. To characterise CD38 on cancer (PC) epithelial TIICs, to associate this with clinical outcomes. RNAseq from 159 patients metastatic castration-resistant (mCRPC) International Stand Up Cancer/Prostate Cancer Foundation (SU2C/PCF) cohort 171 mCRPC samples taken 63 Fred Hutchinson Research...
Histone mutations (H3 K27M, H3 G34R/V) are molecular features defining subtypes of paediatric-type diffuse high-grade gliomas (HGG) (diffuse midline glioma (DMG), K27-altered, hemispheric (DHG), G34-mutant). The WHO classification recognises in exceptional cases, these co-occur. We report one such case a 2-year-old female presenting with neurological symptoms; MRI imaging identified brainstem lesion which was biopsied. Histology showed diffusely infiltrating pleomorphic astrocytes,...
Purpose To develop 3D anatomical models, and corresponding radiographs, of canine jaw fractures. Methods A base model was generated from a mandibular bone scan. With this it possible to perform fracture planning according the location. Results The mandible similar in conformation natural bone, demonstrating structures such as tooth crowns, premolars molars, mental foramina, body mandible, ramus masseteric fossa, coronoid process, condylar angular process. It not obtain detail crown incisor...
Purpose . To analyze whether a viscoelastic mattress support surface can reduce the incidence of stage 2 pressure injuries compared to standard hospital with pyramidal overlay in critically ill patients. Method A randomized clinical trial intention-to-treat analysis was carried out recruiting patients Braden scale ≤14 on intensive care unit admission from April 2016 2017. Patients were allocated into two groups: intervention group (viscoelastic mattress) and control (standard overlay). The...
ABSTRACT Canine Hip Dysplasia (CHD) is a highly prevalent articular pathological condition. In this sense, radiography becomes an important diagnostic method to determine the presence and severity of disease. The objective was create 3D models their respective radiographs representing CHD (3D AMCHD). research carried out in Laboratory Educational Technologies UFAC, under no. 23107.007273/2017-49 (CEUA/UFAC). A canine skeleton (hip bone, femurs patellae) used without anatomical deformities...
Abstract BACKGROUND Histone mutations (H3 K27M, H3 G34R/V) define subtypes of paediatric-type diffuse high-grade gliomas (HGG) (diffuse midline glioma (DMG), K27-altered, hemispheric (DHG), G34-mutant). The WHO classification recognises exceptional cases where these co-occur. We report one such case a 2-year-old female presenting with neurological symptoms and lethargy. METHODS MRI imaging identified brainstem lesion; stereotactic needle biopsy was undertaken, followed by standard diagnostic...
Background This case represents an exceptional response to pembrolizumab in a patient with epithelioid mesothelioma further on rechallenge. Case presentation A 77-year-old woman advanced extensively pretreated chemotherapy demonstrated prolonged of 45 months 52 cycles pembrolizumab. On rechallenge pembrolizumab, disease stability was achieved. Serial biopsies and analysis by immunohistochemistry immunofluorescence marked immune infiltration documented the emergency markers exhaustion. Whole...
Resumo: Introdução: Em janeiro de 2020, a OMS reconheceu pandemia do novo coronavírus no mundo, chegando os casos ao Brasil em fevereiro e Acre março. Uma das respostas para enfrentamento da estado foi o telemonitoramento dos suspeitos confirmados Covid-19, que se viabilizou partir parceria entre Núcleo Telessaúde Acre, as Secretarias Saúde cursos Medicina Universidade Federal (Ufac) Centro Universitário Uninorte. O objetivo artigo é relatar experiência projeto ensino apoio covid-19 Rio...
Coronavirus disease 2019 (COVID-19) is often linked to a broad range of opportunistic bacterial and fungal infections. The second wave the COVID-19 pandemic has witnessed an unprecedented surge in mucormycosis cases, predominantly India, while remained relatively rare Europe. authors describe case 62-year-old female patient admitted hospital for consolidation therapy with chemotherapy as part treatment protocol acute myeloid leukemia. During hospitalization, she was diagnosed nosocomial...
Abstract BACKGROUND Bithalamic gliomas (BTG) are rare brain tumors with dismal prognosis. Optimal management and role of novel therapies have not been established yet. This study aimed to improve our understanding BTG guide adapted treatments. METHODS Retrospective case series across 6 Pediatric Neuro-Oncology Units (United Kingdom, Spain) ≤18-year-old patients between 2000-2022. Clinical, pathological, molecular data were derived reviewed. A systematic review the literature, meta-analysis,...
Abstract BACKGROUND Paediatric-type diffuse high-grade glioma (PDHGG) is recognised in the WHO2021 CNS Tumour Classification as biologically distinct from ‘adult-types’, and comprises four major categories based on biology clinical presentation, though sub-types within these are less well-defined. METHODS Published unpublished genome/exome/targeted sequencing n=1593 cases were integrated with n=2027 methylation array profiling, an overlap of n=761. These supplemented varying availability...
Abstract BACKGROUND High-grade gliomas (HGG) arise in any CNS location with a poor prognosis. HGGs teenagers/young adults (TYA) are understudied; this project aimed to characterise these tumours and identify therapeutic targets. METHODS HGG samples (histone/IDH-wildtype, n=207, FFPE/FF, 13-30 years) were collected from national/international collaborators. DNA methylation profiling (Illumina EPIC BeadArrays, brain tumour classifier (MNPv12.5 R package)) classified cases against reference...