A5064814812- Glioma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Amyotrophic Lateral Sclerosis Research
- Growth Hormone and Insulin-like Growth Factors
- Neuroendocrine Tumor Research Advances
- Neurological diseases and metabolism
- Wound Healing and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cancer and Skin Lesions
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Pressure Ulcer Prevention and Management
- Pituitary Gland Disorders and Treatments
- Hair Growth and Disorders
- Cancer Immunotherapy and Biomarkers
- Skin Protection and Aging
- Cell Adhesion Molecules Research
- Radiopharmaceutical Chemistry and Applications
Northern Health and Social Care Trust
2023-2025
Epistem (United Kingdom)
2016-2017
Abstract Background: High-grade gliomas (HGG) occur in any central nervous system (CNS) location and age. HGGs teenagers/young adults (TYA) are understudied. This project aimed to characterise these tumours support accurate patient stratification. Methods: 207 histone/IDH-wildtype from patients aged 13–30 years were collected. DNA methylation profiling (Illumina EPIC BeadArrays, brain tumour classifier (MNPv12.6 R package)) classified cases against reference cohorts. Calibrated scores guided...
Abstract BACKGROUND High-grade gliomas (HGG) arise in any CNS location with a poor prognosis. HGGs teenagers/young adults (TYA) are understudied; this project aimed to characterise these tumours and identify therapeutic targets. METHODS HGG samples (histone/IDH-wildtype, n=207, FFPE/FF, 13-30 years) were collected from national/international collaborators. DNA methylation profiling (Illumina EPIC BeadArrays, brain tumour classifier (MNPv12.5 R package)) classified cases against reference...
Abstract The hair follicle is a well vascularised structure that contains rapidly dividing epithelial cells. As result it potentially useful surrogate biomarker for less accessible but highly similar tissues, such as proliferating tumours. We have developed an ex vivo culture method to validate target expression changes following exposure DNA damage and/or potential therapeutics. Proof of concept studies performed can then inform the design clinical validation studies. Earlier work evaluated...
Abstract High-grade gliomas (HGG) arise in any central nervous system location, adults and children, with a poor prognosis. HGGs teenagers young (TYA) are understudied; this project aimed to characterise these tumours identify potential therapeutic targets. HGG samples (n=195, FFPE/FF, 13-30 years) were collected, excluding well-characterised entities (histone/IDH-mutant). DNA methylation profiling (Illumina EPIC BeadArrays, brain tumour classifier (MNP v12.5 R package), n=195) classified...