Mellissa Maybury
A5001890076- Acute Lymphoblastic Leukemia research
- Glioma Diagnosis and Treatment
- RNA modifications and cancer
- Chronic Myeloid Leukemia Treatments
- Hedgehog Signaling Pathway Studies
- Acute Myeloid Leukemia Research
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- Cancer Genomics and Diagnostics
- Childhood Cancer Survivors' Quality of Life
- Cell Adhesion Molecules Research
- Renal and related cancers
- RNA and protein synthesis mechanisms
- Circular RNAs in diseases
- Cerebrovascular and genetic disorders
- Epigenetics and DNA Methylation
- Palliative Care and End-of-Life Issues
- Single-cell and spatial transcriptomics
- Biochemical and Molecular Research
- Prenatal Screening and Diagnostics
- Neuroblastoma Research and Treatments
- Genomic variations and chromosomal abnormalities
- Cancer-related molecular mechanisms research
- Digestive system and related health
- Chronic Lymphocytic Leukemia Research
The University of Queensland
2018-2025
Queensland Children’s Hospital
2020
Infant high-grade gliomas appear clinically distinct from their counterparts in older children, indicating that histopathologic grading may not accurately reflect the biology of these tumors. We have collected 241 cases under 4 years age, and carried out histologic review, methylation profiling, custom panel, genome, or exome sequencing. After excluding tumors representing other established entities subgroups, we identified 130 to be part an "intrinsic" spectrum disease specific infant...
OLIG2-expressing tumor stem cells have been shown to drive recurrence in Sonic Hedgehog (SHH)-subgroup medulloblastoma (MB) and patients urgently need specific therapies target this cell population. Here, we investigate the therapeutic potential of brain-penetrant orally bioavailable, OLIG2 inhibitor CT-179, using SHH-MB explant organoids, PDX GEM models. We find that CT-179 disrupts dimerization, phosphorylation DNA binding alters cell-cycle kinetics, increasing differentiation apoptosis....
Abstract Background Brain cancer is the leading cause of cancer-related death in children. Early detection and serial monitoring are essential for better therapeutic outcomes. Liquid biopsy has recently emerged as a promising approach detecting these tumors by screening body fluids presence circulating tumor DNA (ctDNA). Here we tested limits liquid using patient-specific somatic mutations to detect monitor primary metastatic pediatric brain cancer. Methods Somatic were identified 3...
Abstract Acute lymphoblastic leukemia expressing the gamma delta T-cell receptor (γδ T-ALL) is a poorly understood disease. We studied 200 children with γδ T-ALL from 13 clinical study groups to understand and genetic features of this found age drivers were significantly associated outcome. diagnosed in under 3 years was extremely high-risk enriched for alterations that result both LMO2 activation STAG2 inactivation. Mechanistically, using patient samples isogenic cell lines, we show...
Previous studies have highlighted the capacity of brain cancer cells to functionally interact with tumour microenvironment (TME). This TME-cancer crosstalk crucially contributes cell invasion and disease progression. In this study, we performed spatial transcriptomic sequencing analysis a complete annotated tumour-infiltrated brainstem from single diffuse intrinsic pontine glioma (DIPG) patient. Gene signatures ten sequential regions were analysed assess mechanisms progression oncogenic...
Abstract Background: High-grade gliomas (HGG) occur in any central nervous system (CNS) location and age. HGGs teenagers/young adults (TYA) are understudied. This project aimed to characterise these tumours support accurate patient stratification. Methods: 207 histone/IDH-wildtype from patients aged 13–30 years were collected. DNA methylation profiling (Illumina EPIC BeadArrays, brain tumour classifier (MNPv12.6 R package)) classified cases against reference cohorts. Calibrated scores guided...
Recurrence is the primary life-threatening complication for medulloblastoma (MB). In Sonic Hedgehog (SHH)-subgroup MB, OLIG2-expressing tumor stem cells drive recurrence. We investigated anti-tumor potential of small-molecule OLIG2 inhibitor CT-179, using SHH-MB patient-derived organoids, xenograft (PDX) tumors and mice genetically-engineered to develop SHH-MB. CT-179 disrupted dimerization, DNA binding phosphorylation altered cell cycle kinetics
Paediatric palliative care is pivotal for addressing the complex needs of children with incurable diseases and their families. While home-based offers a familiar supportive environment, delivering comprehensive services in this context challenging. The existing literature on lacks detailed guidance its organization implementation. This qualitative narrative inquiry explores provision paediatric care. Data were collected from healthcare practitioners using conversations, storytelling,...
SUMMARY Recurrence after therapy is the primary life-threatening complication of medulloblastoma. In Sonic Hedgehog (SHH)-subgroup medulloblastoma, OLIG2-expressing tumour stem cells are crucial to recurrence. We investigated potential small-molecule OLIG2 inhibitor CT-179 decrease recurrence in patient-derived organoids, mice genetically-engineered develop SHH-driven MB, and with MB xenograft (PDX) tumours. found that mRNA significantly correlated poor survival patients SHH-MB, but not...
ABSTRACT Emerging spatially-resolved sequencing technologies offer unprecedented possibilities to study cellular functionality and organisation, transforming our understanding of health disease. The necessity understand healthy diseased tissues in its entirety becomes even more evident for the human brain, most complex organ body. brain’s architecture corresponding functions are tightly regulated. However, when intercellular communications altered by pathologies, such as brain cancer, these...
<p>The gene expression profiles of γδ T-ALL.</p>
<p>The genomic features of LMO2::STAG2 translocations.</p>
<p>The clinical features of γδ T-ALL.</p>
<p>Coverage of ATAC seq, H3K27ac ChIP and RNAseq at the LIN28B ID1 locus.</p>
<div>Abstract<p>Acute lymphoblastic leukemia expressing the gamma delta T-cell receptor (γδ T-ALL) is a poorly understood disease. We studied 200 children with γδ T-ALL from 13 clinical study groups to understand and genetic features of this found age drivers were significantly associated outcome. diagnosed in under 3 years was extremely high-risk enriched for alterations that result both <i>LMO2</i> activation <i>STAG2</i> inactivation. Mechanistically,...
<p>Supplementary Methods, Supplementary Results, Data Figures 1 and 2</p>