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Lucy S. H. Ock

ORCID: 0000-0002-1680-3954
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About
Contact & Profiles
A5092129048
Research Areas
  • Glioma Diagnosis and Treatment
  • Hedgehog Signaling Pathway Studies
  • Genomic variations and chromosomal abnormalities
  • Cancer Genomics and Diagnostics

QIMR Berghofer Medical Research Institute
 2023-2025

 Suppressing recurrence in Sonic Hedgehog subgroup medulloblastoma using the OLIG2 inhibitor CT-179
OPENALEX - Publications 
Yuchen Li Chaemin Lim Taylor Dismuke Daniel Malawsky Sho Oasa and 26 more Zara C. Bruce Carolin Offenhäuser Ulrich Baumgartner Rochelle C. J. D’Souza Stacey L. Edwards Juliet D. French Lucy S. H. Ock Sneha Nair Haran Sivakumaran Lachlan Harris Andrey P. Tikunov Duhyeong Hwang Coral del Mar Alicea Pauneto Mellissa Maybury Tim Hassall Brandon J. Wainwright Santosh Kesari Gregory Stein Michael Piper Terrance G. Johns Marina Sokolsky‐Papkov Lars Terenius Vladana Vukojević Leon McSwain Timothy R. Gershon Bryan W. Day

OLIG2-expressing tumor stem cells have been shown to drive recurrence in Sonic Hedgehog (SHH)-subgroup medulloblastoma (MB) and patients urgently need specific therapies target this cell population. Here, we investigate the therapeutic potential of brain-penetrant orally bioavailable, OLIG2 inhibitor CT-179, using SHH-MB explant organoids, PDX GEM models. We find that CT-179 disrupts dimerization, phosphorylation DNA binding alters cell-cycle kinetics, increasing differentiation apoptosis....

10.1038/s41467-024-54861-3 article EN cc-by-nc-nd Nature Communications 2025-02-04
 Preventing recurrence in Sonic Hedgehog Subgroup Medulloblastoma using OLIG2 inhibitor CT-179
OPENALEX - Publications 
Yuchen Li Chaemin Lim Taylor Dismuke Daniel Malawsky Sho Oasa and 25 more Zara C. Bruce Carolin Offenhäuser Ulrich Baumgartner Rochele D'Souza Stacey L. Edwards Juliet D. French Lucy S. H. Ock Sneha Nair Haran Sivakumaran Lachlan Harris Andrey P. Tikunov Duhyeong Hwang Coral del Mar Alicea Pauneto Mellissa Maybury Tim Hassall Brandon J. Wainwright Santosh Kesari Gregory Stein Michael Piper Terrance G. Johns Marina Sokolsky‐Papkov Lars Terenius Vladana Vukojević Bryan W. Day Timothy R. Gershon

Recurrence is the primary life-threatening complication for medulloblastoma (MB). In Sonic Hedgehog (SHH)-subgroup MB, OLIG2-expressing tumor stem cells drive recurrence. We investigated anti-tumor potential of small-molecule OLIG2 inhibitor CT-179, using SHH-MB patient-derived organoids, xenograft (PDX) tumors and mice genetically-engineered to develop SHH-MB. CT-179 disrupted dimerization, DNA binding phosphorylation altered cell cycle kinetics

10.21203/rs.3.rs-2949436/v1 preprint EN cc-by Research Square (Research Square) 2023-06-09
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