A5039003649- Glioma Diagnosis and Treatment
- Hedgehog Signaling Pathway Studies
- Radiopharmaceutical Chemistry and Applications
- Advanced Radiotherapy Techniques
- Advanced Electron Microscopy Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Renal and related cancers
- Traumatic Ocular and Foreign Body Injuries
- Shoulder and Clavicle Injuries
- Infrared Thermography in Medicine
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Veterinary Orthopedics and Neurology
- Colorectal and Anal Carcinomas
- Effects of Radiation Exposure
- Radiation Therapy and Dosimetry
- Plant-based Medicinal Research
- Saffron Plant Research Studies
- Digital Radiography and Breast Imaging
- Chemotherapy-related skin toxicity
- Medical Imaging Techniques and Applications
- Brain Metastases and Treatment
- Medical Imaging and Analysis
- Genomic variations and chromosomal abnormalities
- Nanoplatforms for cancer theranostics
The Kids Research Institute Australia
2023-2025
Hospital Universitario HM Sanchinarro
2013
University of Nebraska Medical Center
2012
Murphy Oil Corporation (United States)
1990
University of California, Davis
1990
OLIG2-expressing tumor stem cells have been shown to drive recurrence in Sonic Hedgehog (SHH)-subgroup medulloblastoma (MB) and patients urgently need specific therapies target this cell population. Here, we investigate the therapeutic potential of brain-penetrant orally bioavailable, OLIG2 inhibitor CT-179, using SHH-MB explant organoids, PDX GEM models. We find that CT-179 disrupts dimerization, phosphorylation DNA binding alters cell-cycle kinetics, increasing differentiation apoptosis....
Recurrence is the primary life-threatening complication for medulloblastoma (MB). In Sonic Hedgehog (SHH)-subgroup MB, OLIG2-expressing tumor stem cells drive recurrence. We investigated anti-tumor potential of small-molecule OLIG2 inhibitor CT-179, using SHH-MB patient-derived organoids, xenograft (PDX) tumors and mice genetically-engineered to develop SHH-MB. CT-179 disrupted dimerization, DNA binding phosphorylation altered cell cycle kinetics
The psittacine skull is a complex anatomic structure, frequently traumatized but difficult to adequately image with standard radiographic procedures. Multiple views including ventrodorsal, lateral, and complementary oblique projections are necessary fully evaluate potential fractures in the avian patient. Magnification radiography relatively easy procedure that aids review of small osseous structures. Familiarity anatomy greatly facilitates interpretation cranial trauma.
2061 Background: While external beam radiation therapy (EBRT) remains a central component of the management primary brain tumors, it is limited by tolerance surrounding normal tissue. Rhenium-186 NanoLiposome ( 186 RNL) permits delivery beta-emitting high specific activity with excellent retention in tumor. We report results phase 1 study recurrent glioma. Methods: A Phase dose-escalation RNL glioma utilizing standard 3+3 design was undertaken to determine maximum tolerated dose RNL....
SUMMARY Recurrence after therapy is the primary life-threatening complication of medulloblastoma. In Sonic Hedgehog (SHH)-subgroup medulloblastoma, OLIG2-expressing tumour stem cells are crucial to recurrence. We investigated potential small-molecule OLIG2 inhibitor CT-179 decrease recurrence in patient-derived organoids, mice genetically-engineered develop SHH-driven MB, and with MB xenograft (PDX) tumours. found that mRNA significantly correlated poor survival patients SHH-MB, but not...
The psittacine skull is a complex anatomic structure, frequently traumatized but difficult to adequately image with standard radiographic procedures. Multiple views including ventrodorsal, lateral, and complementary oblique projections are necessary fully evaluate potential fractures in the avian patient. Magnification radiography relatively easy procedure that aids review of small osseous structures. Familiarity anatomy greatly facilitates interpretation cranial trauma.
OLIG2 is a protein transcription factor that expressed exclusively in progenitor cells the brain and spinal cord during development. Typically, not active adult found outside central nervous system; however, it re-expressed most patients with high-grade glioma (HGG). The expression of potentially drives growth, invasiveness, resistance to radiation HGG tumours animal models. CT-179 small molecule (M.W. 397) that, on basis homology modelling studies, putative disruptor homodimerization. We at...
Abstract Olig2 is a bHLH transcription factor that has been shown to be key driver of glioblastoma (GBM) tumorigenesis. expressed in human tumor-derived glioma stem-like cells. A growing body evidence suggests cells (GSCs) are more representative their parent tumors when cultured under defined serum-free conditions with the mitogens epidermal growth (EGF) and fibroblast (FGF). Furthermore, recent research indicated Proneural GSCs grown vitro PDGF tumorigenic vivo. We have designed...
Increased sympathetic outflow is a major contributor to the progression of heart failure (HF). Potentiation peripheral chemoreflex has been related activation nervous system in HF patients and animal models. The carotid body (CB) plays pivotal role increased chemosensitivity animals. Hydrogen sulfide (H 2 S) proposed be key mediator hypoxic response CB chemoreceptors. We hypothesized that H S contributes potentiation hypoxia rats. Using irreversible inhibitor DL‐Propargylglycine (PAG), we...
Olig2 is a lineage-specific bHLH transcription factor in normal brain development and has been shown to be critical oncogene controlling the tumorigenesis, growth, invasion, differentiation radiation resistance of gliomas, including glioblastoma (GBM). Importantly, Olig2-positive glioma stem-like cells (GSCs) are responsible for recurrence disease that occurs most GBM patients. CT-179 small molecule (397 kD) was designed bind dimerization interface Olig2. Based on comparison shOlig2 effects...