A5048202536- Radiopharmaceutical Chemistry and Applications
- Nanoparticle-Based Drug Delivery
- Hemoglobin structure and function
- Medical Imaging Techniques and Applications
- RNA Interference and Gene Delivery
- Diet and metabolism studies
- Nanoplatforms for cancer theranostics
- Nonmelanoma Skin Cancer Studies
- Medical Imaging and Pathology Studies
- Glioma Diagnosis and Treatment
- Diabetes Treatment and Management
- Cutaneous Melanoma Detection and Management
- Radiation Therapy and Dosimetry
- Advanced biosensing and bioanalysis techniques
- Immunotherapy and Immune Responses
- Neonatal Health and Biochemistry
- Diet, Metabolism, and Disease
- Erythrocyte Function and Pathophysiology
- Atomic and Subatomic Physics Research
- Brain Metastases and Treatment
- Radiation Dose and Imaging
- Gastrointestinal motility and disorders
- Orthopedic Infections and Treatments
- Advanced Radiotherapy Techniques
- Advanced Electron Microscopy Techniques and Applications
The University of Texas Health Science Center at San Antonio
2014-2025
The University of Texas Health Science Center at Houston
1994-2025
Mays Cancer Center at UT Health San Antonio
2021-2025
Memorial Sloan Kettering Cancer Center
2014-2024
La Trobe University
2024
University of Ottawa
2023
GTx (United States)
2023
University of Rochester
2021
Brooke Army Medical Center
2018
The University of Texas at San Antonio
1991-2011
Intravenously administered multi-walled carbon nanotubes, functionalized with DTPA and radiolabeled Indium-111, were dynamically tracked in vivo using a microSingle Photon Emission Tomography scanner. Imaging showed that nanotubes enter the systemic blood circulation within 5 min begin to permeate through renal glomerular filtration system into bladder.
A major obstacle in the development of red cell substitutes has been overcoming their short circulation persistence. In this study, distearoyl phosphoethanolamine polyethylene glycol 5000 (PEG-PE) (10 mol%) was added to formulation liposome-encapsulated hemoglobin (LEH) decrease reticuloendothelial system uptake and prolong LEH PEG-LEH radiolabeled with technetium-99m, infused into rabbits (25% blood pool at 1 ml/min) (n = 5), monitored by scintigraphic imaging various times out 48 h. At h,...
Although external beam radiation is an essential component to the current standard treatment of primary brain tumors, its application limited by toxicity at doses more than80 Gy. Recent studies have suggested that brachytherapy with liposomally encapsulated radionuclides may be benefit, and we reported methods markedly increase specific activity rhenium-186 (186Re)–liposomes. To better characterize potential delivery, toxicity, efficacy highly 186Re-liposomes, evaluated their intracranial...
The 2006 National Academy of Sciences Biologic Effects Ionizing Radiation (BEIR) VII report is a well-recognized and frequently cited source on the legitimacy linear no-threshold (LNT) model-a model entailing causal relationship between ionizing radiation human cancer risk. Linearity means that all causes explicitly excludes threshold below which radiogenic risk disappears. However, BEIR committee has erred in interpretation its selected literature; specifically, vitro data quoted fail to...
Abstract Response to immunotherapies can be variable and unpredictable. Pathology-based phenotyping of tumors into ‘hot’ ‘cold’ is static, relying solely on T-cell infiltration in single-time single-site biopsies, resulting suboptimal treatment response prediction. Dynamic vascular events (tumor angiogenesis, leukocyte trafficking) within tumor immune microenvironment (TiME) also influence anti-tumor immunity response. Here, we report dynamic cellular-level TiME vivo that combines...
Pharmacokinetic and organ distribution studies of liposomal drugs in humans are a challenge. A direct labeling method using (99m)Tc-N,N-bis(2-mercaptoethyl)-N',N'-diethyl-ethylenediamine (BMEDA) complex to label the commercially available pegylated doxorubicin, Doxil, has been introduced. Biodistributions (99m)Tc-Doxil normal rats were performed evaluate feasibility it for monitoring pharmacokinetics liposomes encapsulating drugs. Labeling efficiency was 70.6 +/- 0.8% (n = 3). In vitro...
OBJECTIVE To estimate the rate of gastric emptying a solid pancake carbohydrate meal in recently diagnosed asymptomatic type II diabetic patients compared with nondiabetic control subjects. RESEARCH DESIGN AND METHODS Gastric studies using radiolabeled meals were performed on eight and sex-, BMI- age-matched Although liquid protein drink was administered along meal, radioactivity adherent to only portion meal. Plasma glucose serum insulin levels measured fasting postprandial blood samples...
To prepare long-circulating liposomes, poly(ethylene glycol) (PEG)-lipid is usually mixed with other lipid components before vesicle formation. PEG-lipids can also be postinserted in the outer layer of liposomes after preparation. In this study, PEG-distearoylphosphatidylethanolamine was incorporated by postinsertion technique into liposome-encapsulated hemoglobin (LEH) carrying neutral or negative charge. Postinsertion improved encapsulation efficiency from about 0.0017 to 0.017...
Liposome-encapsulated hemoglobin (LEH) is an erythrocyte substitute that a potential resuscitative fluid for the in vivo delivery of oxygen. We have noninvasively imaged radiolabeled LEH with technetium-99m (99mTc) to study biodistribution anesthetized rabbit. Rabbits (2.5 kg, n = 8) were infused 30 ml (200 mg phospholipid, 2.5 g per kg body weight) and gamma camera continuously 2 hr. At 20 hr postinfusion, animals again sacrificed; organs weighted their radioactivity was determined autopsy...
Mohs surgery for the removal of nonmelanoma skin cancers (NMSCs) is performed in stages, while being guided by examination residual tumor with frozen pathology. However, preparation pathology at each stage time consuming and labor intensive. Real-time intraoperative reflectance confocal microscopy(RCM), combined video mosaicking, may enable rapid detection directly surgical wounds on patients. We report our initial experience 25 patients, using aluminum chloride nuclear contrast. Imaging was...
Introduction The aim of this study was to determine if specific anatomical changes were present in patients with recurrent headaches including chronic migraines, tension-type headaches, and daily persistent headaches. A retrospective 200 performed evaluate the potential measuring amount nasal blood pool activity (nasal congestion) as a predictive marker for Methods cohort analysis involving who had been referred Nuclear Medicine Clinic over 3-year period whole-body scans. scans evaluated by...
Abstract Rhenium ( 186 Re) Obisbemeda RNL), chelated- Re encapsulated in nanoliposomes and delivered to brain tumors via convection enhanced delivery (CED), was evaluated a Phase 1 dose escalation trial (NCT01906385). The primary objective determine the maximum tolerated (MTD). Secondary objectives included safety tolerability, distribution, overall response rate (ORR), disease-specific progression-free survival (PFS), (OS). 21 patients received up 22.3 mCi RNL over 6 dosing cohorts. Most...
Phospholipid vesicles encapsulating concentrated human hemoglobin (Hb-vesicles, HbV), also known as liposomes, have a membrane structure similar to that of red blood cells (RBCs). These circulate in the bloodstream an oxygen carrier, and their circulatory half-life times (<i>t</i><sub>1/2</sub>) biodistribution are fundamental characteristics required for representation efficacy safety RBC substitute. Herein, we report pharmacokinetics HbV empty (EV) do not contain Hb, rats rabbits evaluate...