A5019498881- Glioma Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Sarcoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Toxic Organic Pollutants Impact
- Melanoma and MAPK Pathways
- Cancer, Hypoxia, and Metabolism
- Carcinogens and Genotoxicity Assessment
- Pesticide Exposure and Toxicity
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Synthesis and biological activity
- Computational Drug Discovery Methods
- HER2/EGFR in Cancer Research
- CAR-T cell therapy research
- Occupational Health and Performance
- Multiple and Secondary Primary Cancers
- Cancer Genomics and Diagnostics
- Cardiac Arrest and Resuscitation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Statistical Methods and Bayesian Inference
- Colorectal Cancer Treatments and Studies
- Cancer, Lipids, and Metabolism
- Radiopharmaceutical Chemistry and Applications
The University of Texas Health Science Center at San Antonio
2016-2025
Mays Cancer Center at UT Health San Antonio
2018-2025
The University of Texas Health Science Center at Houston
2010-2025
The University of Texas at San Antonio
2010-2024
Cancer Research And Biostatistics
2007-2023
Tata Memorial Hospital
2023
Pediatrics and Genetics
2023
University of Nevada, Las Vegas
2022
Cleveland Clinic
2010-2022
Audie L. Murphy Memorial VA Hospital
2007-2019
In Brief Objective: To determine the effect of blood component ratios in massive transfusion (MT), we hypothesized that increased use plasma and platelet to red cell (RBC) would result decreased early hemorrhagic death this benefit be sustained over ensuing hospitalization. Summary Background Data: Civilian guidelines for (MT ≥10 units RBC 24 hours) have typically recommend a 1:3 ratio plasma:RBC, whereas optimal platelet:RBC are unknown. Conversely, military data shows plasma:RBC...
Abstract Objective. To measure, and seek clinical correlates with, levels of substance P (SP) in the cerebrospinal fluid (CSF) fibromyalgia syndrome (FMS) patients. Methods. CSF from 32 FMS patients 30 normal control subjects was tested for SP by radio‐immunoassay. Clinical measures included tender point examination standardized questionnaires. Results. were 3‐fold higher than controls (P < 0.001), but they correlated only weakly with tenderness found on examination. Conclusion. is...
Abstract Objective To evaluate the safety and efficacy of sodium oxybate for management symptoms fibromyalgia syndrome (FMS). Methods Patients with FMS (according to American College Rheumatology 1990 criteria) were randomized, after discontinuing their prestudy medications FMS, receive 4.5 gm or 6 matching placebo once per night 8 weeks. The primary outcome variable (POV) was a composite score changes from baseline in 3 coprimary self‐report measures: patient's pain rating (in daily...
Abstract Purpose: Glioblastoma represents the most common primary brain tumor. Although antiangiogenics are used in recurrent setting, they do not prolong survival. is known to upregulate fatty acid synthase (FASN) facilitate lipid biosynthesis. TVB-2640, a FASN inhibitor, impairs this activity. Patients and Methods: We conducted prospective, single-center, open-label, unblinded, phase II study of TVB-2640 plus bevacizumab patients with high-grade astrocytoma. were randomly assigned (100...
In a population-based case-control study of women younger than 45 years age, we obtained detailed lifetime history alcohol use to evaluate the effects drinking during different periods life in relation breast cancer risk. This analysis focused on interviews from 1,645 cases and 1,497 controls. Breast risk was not influenced by teenage or early adulthood. Contemporary (that is, average intake recent 5-year interval) directly associated with risk, but adverse effect restricted who consumed ≥14...
Abstract The half‐life of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (2,3,7,8‐TCDD; commonly known as dioxin) in serum has been measured 36 Air Force Vietnam veterans Operation Ranch Hand, which was the operation that aerially sprayed herbicide Agent Orange Vietnam. From specimens taken 1982 and 1987, median 2,3,7,8‐TCDD these Hand found to be 7.1 yr (95% confidence interval about 5.8–9.6 yr). These reported no civilian exposure dioxin or herbicides. Concentrations from ranged 16.9 423 parts per...
Background: The high-density lipoprotein (HDL) cholesterol level is a strong predictor of cardiovascular events in epidemiologic studies. Until recently, it has been less extensively studied as therapeutic target. Objective: To assess the angiographic and clinical effects pharmacologic strategy to increase HDL levels. Design: Randomized, double-blind, placebo-controlled trial conducted from 1993 1996. Setting: Outpatient specialty clinic large U.S. military medical center. Participants: 143...
Abstract We examined the role of MCP-1, a potent chemotactic and activating factor for macrophages, in perfusion, inflammation, skeletal muscle regeneration post-ischemic injury. MCP-1−/− or C57Bl/6J control mice [wild-type (WT)] underwent femoral artery excision (FAE). Muscles were collected histology, assessment tissue chemokines, activity measurements lactate dehydrogenase (LDH) myeloperoxidase. In mice, restoration perfusion was delayed, LDH fiber size, indicators regeneration,...
Background: Several recent military and civilian trauma studies demonstrate that improved outcomes are associated with early increased use of plasma-based resuscitation strategies. However, platelet transfusions poorly characterized. We hypothesized platelet:red blood cells (RBC) ratios would decrease hemorrhagic death improve survival after massive transfusion (MT). Methods: A database patients transported from the scene to 22 Level I Trauma Centers over 12 months in 2005 2006 was reviewed....
Among male air force veterans of the Vietnam era, age-adjusted testosterone levels are lower in married men than among those who single or divorced. Contrary to assumption some sociological studies, level is not constant over time. Testosterone relatively high during years surrounding a divorce, and falls marriage. Changing may explain low criminality found increase abuse wives around time divorce.
For 1704 patients with large bowel cancer compiled by the Armed Forces Central Medical Registry, selected prognostic factors were related to five-year or longer survival. The majority of late deaths (those occurring after five years) resulted from in descending colon, sigmoid colon rectum rather than right transverse colon. example, among all rectum, 15.4% those Dukes' B tumors and 10.9% C died rectal between ten years diagnosis. When survival rates compared, (8 deaths/93 at risk) fared...
The regulation of vascular endothelial growth factor (VEGF) levels and angiogenic events during skeletal muscle regeneration remains largely unknown. This study examined angiogenesis, VEGF levels, after cardiotoxin (CT)-induced injury in mice lacking the CC chemokine receptor 2 (CCR2). Muscle was significantly decreased CCR2-/- as early accumulation macrophages injury. In both mouse strains, tissue similar at baseline (no injections) day 3 post-CT. Tissue wild-type (WT) restored within 7...
Most BRCA1-associated breast tumours are basal-like yet originate from luminal progenitors. BRCA1 is best known for its functions in double-strand break repair and resolution of DNA replication stress. However, it unclear whether loss these ubiquitously important fully explains the cell lineage-specific tumorigenesis. In vitro studies implicate elimination R-loops, DNA-RNA hybrid structures involved transcription genetic instability. Here we show that R-loops accumulate preferentially...
Muscle regeneration requires CC chemokine receptor 2 (CCR2) expression on bone marrow-derived cells; macrophages are a prominent CCR2-expressing cell in this process. CCR2-/- mice have severe impairments angiogenesis, macrophage recruitment, and skeletal muscle following cardiotoxin (CTX)-induced injury. However, multiple chemokines activate CCR2, including monocyte chemotactic proteins (MCP)-1, -3, -5. We hypothesized that MCP-1 is the ligand mediates present mice. examined regeneration,...
Lineage or cell of origin cancers is often unknown and thus not a consideration in therapeutic approaches. Alveolar rhabdomyosarcoma (aRMS) an aggressive childhood cancer for which the remains debated. We used conditional genetic mouse models aRMS to activate pathognomonic Pax3:Foxo1 fusion oncogene inactivate p53 several stages prenatal postnatal muscle development. reveal that lineage significantly influences tumor histomorphology sensitivity targeted therapeutics. Furthermore, we...
Abstract Sacituzumab Govitecan (SG) is an antibody-drug conjugate that has demonstrated efficacy in patients with TROP-2 expressing epithelial cancers. In a xenograft model of intracranial breast cancer, SG inhibited tumor growth and increased mouse survival. We conducted prospective window-of-opportunity trial (NCT03995706) at the University Texas Health Science Center San Antonio to examine intra-tumoral concentrations activity undergoing craniotomy for cancer brain metastases (BCBM) or...
Substance P (SP), a putative nociceptive transmitter, is increased in the CSF of patients with fibromyalgia syndrome (FMS). Because excitatory amino acids (EAAs) also appear to transmit pain, we hypothesized that EAAs may be similarly involved this syndrome. We found mean concentrations most did not differ amongst groups subjects primary FMS (PFMS), associated other conditions (SFMS), painful exhibiting (OTHER) or age-matched, healthy normal controls (HNC). However, SFMS patients, individual...
Chemokines recruit inflammatory cells to sites of injury, but the role CC chemokine receptor 2 (CCR2) during regenerative processes following ischemia is poorly understood. We studied inflammation, perfusion, capillary formation, monocyte chemotactic protein-1 (MCP-1) levels, muscle regeneration, fat accumulation, and transcription factor activation in hindlimb muscles CCR2−/− wild-type (WT) mice femoral artery excision (FAE). In both groups, injury restoration vascular perfusion were...
Data from several epidemiologic studies suggest that exposure to unusually high amounts of dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin) increases the risk diabetes mellitus, and experimental data mechanism for this is decreased cellular glucose uptake. To investigate doseresponse relation more closely, we examined association serum level with prevalence mellitus levels insulin among 1,197 veterans in Air Force Health Study who never had contact dioxin-contaminated herbicides whose was within...