A5027560115- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Colorectal Cancer Screening and Detection
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Gastrointestinal Tumor Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal disorders and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Gallbladder and Bile Duct Disorders
- Biliary and Gastrointestinal Fistulas
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Radiomics and Machine Learning in Medical Imaging
- Metastasis and carcinoma case studies
- Pancreatitis Pathology and Treatment
- Hepatitis B Virus Studies
- Celiac Disease Research and Management
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Pediatric Hepatobiliary Diseases and Treatments
Loyola University Medical Center
2012-2023
The Task Force for Global Health
2022-2023
Loyola Medicine
2013-2023
The University of Texas at San Antonio
2023
The University of Texas Health Science Center at San Antonio
2023
University Hospitals Coventry and Warwickshire NHS Trust
2023
Yale New Haven Hospital
2017-2022
Loyola University Chicago
2013-2021
University Hospital Coventry
2019-2021
Yale University
2015-2020
<h3>Background</h3> White light endoscopy with random biopsies is the standard for detection of intestinal metaplasia (IM) and neoplasia in patients Barrett9s oesophagus (BO). Narrow band imaging (NBI) highlights surface patterns that correlate IM BO. <h3>Objective</h3> To compare high-definition white (HD-WLE) NBI <h3>Design</h3> International, randomised, crossover trial comparing HD-WLE NBI. Patients referred BO screening/surveillance at three tertiary referral centres were prospectively...
Abstract Objective: Weight gain is an important risk factor for gastroesophageal reflux disease (GERD); however, whether weight loss can lead to resolution of GERD symptoms not clear. Our aim was measure the impact on symptoms. Design and Methods: In a prospective cohort study at tertiary referral center, overweight/obese subjects (BMI 25‐39.9 kg/m2) were enrolled in structured program. strategies included dietary modifications, increased physical activity behavioral changes. At baseline 6...
<h3>Objective</h3> Cap-assisted colonoscopy (CAC) uses a small plastic transparent cap attached to the tip of colonoscope that can depress and flatten colonic folds thus improve visualisation their proximal aspects. The aim this study was compare CAC with standard (SC; high-definition white light) for adenoma detection rates. <h3>Design</h3> This is prospective randomised controlled trial. <h3>Setting</h3> performed in tertiary-care Veterans Affairs Medical Center USA. <h3>Patients</h3>...
Epidemiologic and animal studies implicate overconsumption of fructose in the development nonalcoholic fatty liver disease, but molecular mechanisms underlying fructose-induced chronic diseases remain largely unknown. Here, we have presented evidence supporting essential function lipogenic transcription factor carbohydrate response element-binding protein (ChREBP) mediating adaptive responses to protecting against hepatotoxicity. In WT mice, a high-fructose diet (HFrD) activated hepatic...
SLC39A8 encodes ZIP8, a divalent metal ion transporter. Mutations in the gene are associated with congenital disorder of glycosylation type II and Leigh syndrome. Notably, affected patients both disorders exhibited severe manganese (Mn) deficiency. The cellular function human (hSLC39A8) mechanisms by which mutations this protein lead to diseases unclear. Herein, we show that hSLC39A8 mediates 54Mn uptake cells, its expression is regulated Mn. While wild-type increased activity,...
BackgroundMore primary care providers (PCPs) have begun to embrace the use of point-of-care ultrasound (POCUS), but little is known about how PCPs are currently using POCUS and what barriers exist. In this prospective study, largest systematic survey among PCPs, we assessed current use, program management, training needs for in care.MethodsWe conducted a observational study all VA Medical Centers (VAMCs) between June 2019 March 2020 web-based sent VAMC Chiefs Staff clinics...
OBJECTIVES: Probe-based confocal laser endomicroscopy (pCLE) is an imaging technique that allows real-timein vivohistological assessment of Barrett's esophagus (BE). The objectives this study were to create and test novel pCLE criteria for dysplastic BE (phase I), evaluate accuracy, interobserver variability, learning curve in dysplasia prediction II) using these criteria. METHODS: In phase I, 50 videos, a expert gastrointestinal pathologist formulated new by consensus. These tested refined...