A5012025683- Cervical Cancer and HPV Research
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Bladder and Urothelial Cancer Treatments
- Gastrointestinal Tumor Research and Treatment
- Sarcoma Diagnosis and Treatment
- Cardiac Valve Diseases and Treatments
- Cardiovascular Disease and Adiposity
- Soil erosion and sediment transport
- Genetic and Kidney Cyst Diseases
- Tumors and Oncological Cases
- Cutaneous Melanoma Detection and Management
- Neuroblastoma Research and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Genetic factors in colorectal cancer
- Virus-based gene therapy research
- Renal and Vascular Pathologies
- Renal cell carcinoma treatment
- Soil and Water Nutrient Dynamics
- Renal and related cancers
- Nuclear Receptors and Signaling
University of Kansas Medical Center
2007-2024
University Medical Center
2022-2024
University of Kansas
2010-2023
MSD K.K. (Japan)
2022
Novartis (Switzerland)
2022
American Society for Radiation Oncology
2022
Jazz Pharmaceuticals (United States)
2022
PharmaMar (Spain)
2022
Novocure (Jersey)
2022
Takeda (United States)
2022
Bile acids are signaling molecules that critically control hepatocellular function. Disrupted bile acid homeostasis may be implicated in the pathogenesis of chronic liver diseases. Glutathione is an important antioxidant protects against oxidative injury. Various forms disease share common characteristics reduced cellular glutathione and elevated stress. This study reports a potentially novel physiological function regulating hepatic sulfur amino metabolism. We found strongly inhibited...
Abstract Macrophage migration inhibitory factor (MIF1) is a pleiotropic cytokine involved in inflammation and cancer. Genetic knockout of Mif1 the validated N ‐butyl‐ ‐(4‐hydroxybutyl) nitrosamine (BBN) model bladder cancer (BCa) resulted stage arrest at non‐muscle‐invasive disease prior studies. Small‐molecule inhibition MIF1 reduced cancer‐associated outcomes, but it did not fully recapitulate genetic models. D‐dopachrome tautomerase (gene symbol DDT ), commonly referred to as MIF2,...
Cribriform adenocarcinoma of minor salivary gland (CAMSG) is a rare tumor the head and neck. We report case 70‐year‐old female who presented with 4–5‐month history left neck mass. CT scan showed mass just inferior to angle mandible tonsillar prominence. Fine‐needle aspiration (FNA) epithelial groups focal cribriform architecture. The cells had round oval nuclei fine chromatin. background contained scattered lymphocytes. A preliminary diagnosis low grade features metastatic lymph node was...
No AccessJournal of UrologyAdult Urology1 Feb 2009Effects Short-Term Finasteride on Apoptotic Factors and Androgen Receptors in Prostate Cancer Cells Robert Bass, Billy Perry, Peter Langenstroer, J. Brantley Thrasher, Katie L. Dennis, Osama Tawfik, Jeffrey Holzbeierlein BassRobert Bass Financial interest and/or other relationship with Merck Pharmaceuticals. More articles by this author , PerryBilly Perry LangenstroerPeter Langenstroer ThrasherJ. Thrasher DennisKatie Dennis TawfikOsama Tawfik...
Groove pancreatitis is a rare form of chronic affecting the "groove" pancreas among pancreatic head, duodenum, and common bile duct. The exact cause unknown, although there are associations with long-term alcohol abuse, smoking, peptic ulcer disease, heterotopic pancreas, gastric resection, biliary anatomical or functional obstruction minor papilla. diagnosis can be challenging. Endoscopic ultrasound (EUS) magnetic resonance cholangiopancreatography preferred imaging modalities. treatment...
Pyruvate dehydrogenase kinase 4 (PDK4) is a mitochondrial isozyme in the PDK family (PDK1-4) partially responsible for phosphorylation of pyruvate (PDH). Phosphorylation PDH thought to result pro-proliferative shift metabolism that sustains growth cancer cells. Previous data from our lab indicate pan-PDK inhibitor dichloroacetate (DCA) or acute genetic knockdown PDK4 blocks proliferation bladder (BCa) The goal this study was determine role an vivo BCa model, with hypothesis depletion would...
Biological differences exist between strains of laboratory mice, and it is becoming increasingly evident that there are substrains. In the C57BL/6 mouse, primary substrains called 6J 6N. Previous studies have demonstrated 6N mice differ in response to many experimental models human disease. The aim our study was determine if terms their acute carbon tetrachloride (CCl 4 ) exposure. Mice were given CCl once euthanized 12 96 h later. Relative we found had increased liver injury but more rapid...
Chronic ethanol overconsumption promotes alcohol-associated liver disease (ALD), characterized by hepatocyte injury, inflammation, hepatic stellate cell (HSC) activation, and fibrosis. Hyaluronan (HA) concentration is greater in livers blood from advanced ALD patients than with non-ALD. In the liver, HSCs are major HA producers. The relationship between ethanol, HA, HSC activation incompletely understood. Thus, here, we tested hypothesis that enhances a HA-dependent manner.Liver tissue...
Malignant and advanced gastrointestinal stromal tumors (GIST) are currently treated with imatinib mesylate, an inhibitor of KIT PDGFRA receptor tyrosine kinase. Pathologic evaluation residual disease is the gold standard in these cases, as clinical radiologic assessments treatment response do not always correlate pathologic response. Phenotypic genotypic changes may also occur which have impact on decisions. This review will focus role pathologist ordering appropriate testing for primary...
Polycystic liver disease (PLD) is characterized by the growth of numerous biliary cysts and presents in patients with autosomal dominant polycystic kidney (ADPKD), causing significant morbidity. Interestingly, deletion intraflagellar transport-B (IFT-B) complex genes adult mouse models ADPKD attenuates severity PKD PLD. Here we examine role an IFT-A gene, Thm1, PLD juvenile Pkd2 conditional knockout mice. Perinatal Thm1 resulted disorganized expanded regions, fibrosis, increased serum bile...
Melanomas are known as the great mimicker and must be considered in differential diagnosis of any fine-needle aspirations (FNA). Despite recent advancements understanding mutational landscape melanomas, there still exists a divide between genetic morphologic correlates. A consecutive cohort 39 FNA clinically verified metastatic melanomas with concurrent BRAF V600 assessment were selected [positive (n = 18) wild-type 21)]. The melanoma cytology specimens evaluated blinded to mutation status...
We report a case of 65-year-old female who had total thyroidectomy 12 years ago for papillary thyroid carcinoma (PTC) presented with recurrent bed mass. Fine-needle aspiration biopsy yielded malignant cells, consistent squamous cell (SCCa). Surgical resection was performed, and histologic evaluation the mass showed mixed PTC SCCa. The tumor cells were positive BRAF V600E mutation. Thyroid carcinomas admixed SCCa are rare associated aggressive behavior, high rates metastasis, poor outcomes....