Kenneth J. Caldwell
A5090398355- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Hematopoietic Stem Cell Transplantation
- Traumatic Brain Injury and Neurovascular Disturbances
- Multiple Myeloma Research and Treatments
- Neuroblastoma Research and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Protein Degradation and Inhibitors
- CAR-T cell therapy research
- Cancer therapeutics and mechanisms
- Sarcoma Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Chromatin Remodeling and Cancer
- Insects and Parasite Interactions
- Testicular diseases and treatments
- Renin-Angiotensin System Studies
- Adrenal and Paraganglionic Tumors
- S100 Proteins and Annexins
- Eosinophilic Disorders and Syndromes
- Parasitic Infections and Diagnostics
- Topological and Geometric Data Analysis
- Polyomavirus and related diseases
- Injury Epidemiology and Prevention
Gilead Sciences (United States)
2023-2025
Polish Academy of Sciences
2023
Johns Hopkins University
2021-2022
Johns Hopkins All Children's Hospital
2021-2022
University of Florida
2013-2021
St. Jude Children's Research Hospital
2020-2021
Florida College
2021
University of Tennessee Health Science Center
2020
Boston Children's Hospital
2017-2018
Allen Institute for Brain Science
2013
Immunotherapy with chimeric antigen receptor (CAR) T cells is actively being explored for pediatric brain tumors in preclinical models and early phase clinical studies. At present, it unclear which CAR target antigens are consistently expressed across different tumor types. In addition, the extent of HLA class I expression unknown, critical recognition by conventional αβTCR cells.We profiled 49 low- high-grade patient-derived orthotopic xenografts (PDOX) flow analysis 5 targets (B7-H3, GD2,...
Abstract Acute lymphoblastic leukemia expressing the gamma delta T-cell receptor (γδ T-ALL) is a poorly understood disease. We studied 200 children with γδ T-ALL from 13 clinical study groups to understand and genetic features of this found age drivers were significantly associated outcome. diagnosed in under 3 years was extremely high-risk enriched for alterations that result both LMO2 activation STAG2 inactivation. Mechanistically, using patient samples isogenic cell lines, we show...
Patients with acute myeloid leukemia (AML) ineligible for intensive chemotherapy (IC) have limited treatment options. The phase 3 ENHANCE-3 study aimed to determine whether magrolimab (magrolimab arm) was superior placebo (control when either combined venetoclax and azacitidine. Adults previously untreated AML who were IC randomized receive (1 mg/kg on days 1 4, 15 day 8, 30 11 15, then weekly 5 weeks, every 2 weeks) or placebo, (100 mg 1, 200 2, 400 daily thereafter), azacitidine (75 mg/m2...
Stroke is the number one cause of disability and third leading death in world, costing an estimated $70 billion United States 20091, 2. Several models cerebral ischemia have been developed to mimic human condition stroke. It has suggested that up 80% all strokes result from ischemic damage middle artery (MCA) area3. In early 1990s, endothelin-1 (ET-1) 4 was used induce by applying it directly adjacent surface MCA after craniotomy. Later, this model modified 5 using a stereotaxic injection...
Abstract Infantile fibrosarcoma (IFS) is a rare pediatric cancer that typically presents early in life. Surgical resection commonly curative; however, sometimes not possible requiring additional multimodal treatment. IFS harbors fusion one of the neurotrophic receptor tyrosine kinase ( NTRK ) genes. Larotrectinib, highly selective inhibitor tropomyosin (TRK), has been shown to be well tolerated and effective children as young 1‐month old. We report case newborn treated with larotrectinib....
Background Hematopoietic stem cells mobilize to the peripheral circulation in response stroke. However, mechanism by which brain initiates this mobilization is uncharacterized. Methods Animals underwent a murine intraluminal filament model of focal cerebral ischemia and SDF1-A pathway was evaluated blinded manner via serum level assessment, Lin−/Sca1+ cell quantification, exogenous migration confirmation; all with or without blockade. Results Bone marrow demonstrated significant increase...
Secondary myelodysplastic syndromes and acute myeloid leukemia (sMDS/AML) are rare in children adolescents have a dismal prognosis. The mainstay therapy is hematopoietic cell transplantation (HCT), but there has been no innovation cytoreductive regimens. CP X-351, fixed 5:1 molar ratio of liposomal cytarabine to daunorubicin, shown favorable safety efficacy elderly individuals with secondary AML relapsed de novo AML. We report the outcomes 7 young patients (6 newly diagnosed sMDS/AML 1...
• A 3-year-old girl had the typical features of visceral larva migrans syndrome, including hypereosinophilia, recurrent pulmonary infiltrates, and elevated serum IgG, IgE, isohemagglutinin titers. marked mitogenic response her cultured lymphocytes to<i>Toxocara</i>antigen but not to<i>Ascaris</i>antigen was found. neutrophil chemotactic abnormality to<i>Escherichia coli</i>culture filtrates zymosan-activated sera also demonstrated, which partially corrected after she treated with...
Children and adolescents with recurrent metastatic solid tumors have a poor outcome. A previous phase 1 study (ANGIO1) targeting angiogenesis bevacizumab, sorafenib, cyclophosphamide, demonstrated signal of activity in subset patients. Here we report the results cohort pediatric young adult patients treated at recommended 2 doses.Electronic medical records refractory or who received ANGIO1 therapy were reviewed. Treatment cycles lasted 21 days included cyclophosphamide. Toxicities assessed...
Although outcomes for patients with high-risk neuroblastoma improved after the addition of a chimeric anti-GD2 monoclonal antibody (dinutuximab) as treatment minimal residual disease, nearly half these die disease. Recent studies demonstrated efficacy combination chemotherapy mAb in relapsed or newly diagnosed This retrospective case series describes 6 treated at St Jude Children’s Research Hospital an induction regimen containing dinutuximab and chemotherapy, followed by consolidation...
Creation of a cranial window is method that allows direct visualization structures on the cortical surface brain1-3. This technique can be performed in many locations overlying rat cerebrum, but most easily carried out by creating craniectomy over readily accessible frontal or parietal bones. Most frequently, we have used this combination with endothelin-1 middle cerebral artery occlusion model ischemic stroke to quantify changes vessel diameter occur injection into brain parenchyma adjacent...
Stroke is the number one cause of disability and third leading death in world, costing an estimated $70 billion United States 20091, 2. Several models cerebral ischemia have been developed to mimic human condition stroke. It has suggested that up 80% all strokes result from ischemic damage middle artery (MCA) area3. In early 1990s, endothelin-1 (ET-1) 4 was used induce by applying it directly adjacent surface MCA after craniotomy. Later, this model modified 5 using a stereotaxic injection...
<p>The gene expression profiles of γδ T-ALL.</p>
<p>The genomic features of LMO2::STAG2 translocations.</p>
<p>The clinical features of γδ T-ALL.</p>
<p>Coverage of ATAC seq, H3K27ac ChIP and RNAseq at the LIN28B ID1 locus.</p>