A5079239953- Hemoglobinopathies and Related Disorders
- Blood Coagulation and Thrombosis Mechanisms
- Parvovirus B19 Infection Studies
- Venous Thromboembolism Diagnosis and Management
- Vascular Malformations and Hemangiomas
- Acute Ischemic Stroke Management
- Iron Metabolism and Disorders
- Central Venous Catheters and Hemodialysis
- Adolescent and Pediatric Healthcare
- melanin and skin pigmentation
- Genetic Associations and Epidemiology
- Hearing, Cochlea, Tinnitus, Genetics
- Childhood Cancer Survivors' Quality of Life
- Dermatological and COVID-19 studies
- Mast cells and histamine
- Erythrocyte Function and Pathophysiology
- Vestibular and auditory disorders
- Bone Metabolism and Diseases
- Neonatal and fetal brain pathology
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Prenatal Screening and Diagnostics
- Hemophilia Treatment and Research
- RNA modifications and cancer
- Blood groups and transfusion
St. Jude Children's Research Hospital
2019-2025
University of Tennessee Health Science Center
2024
Johns Hopkins University
2001-2019
Bidirectional relationships exist among sickle cell disease (SCD), sleep-disordered breathing (SDB), and hydroxyurea therapy, this complex interplay poses challenges to research attempting elucidate causal mechanisms determine therapeutic targets. We therefore set out study all three components of clinical triad simultaneously (SCD, SDB, therapy), documenting correlations suggesting underlying pathophysiological mechanisms. Hydroxyurea therapy was associated with improved SDB decreased...
Kaposiform lymphangiomatosis (KLA) is a rare, life-threatening congenital lymphatic malformation. Diagnosis often delayed due to complex indistinct symptoms. Blood angiopoietin-2 (ANG2) levels are elevated in KLA and may be useful as biomarker monitor disease status. We report 7-year-old male child with easy bruising, inguinal swelling, consumptive coagulopathy, diagnosed KLA. A multimodal treatment regimen of prednisone, sirolimus, vincristine, adjunctive zoledronate was used. Plasma ANG2...
The literature on cognitive and academic outcomes for children with sickle cell disease (SCD) who experience perinatal risk factors is limited. We aimed to evaluate if low birthweight (LBW), gestational age, history of neonatal intensive care unit (NICU) admission were associated neurocognitive functioning, grade retention, or receipt early intervention formal educational support in SCD.
Secondary myelodysplastic syndromes and acute myeloid leukemia (sMDS/AML) are rare in children adolescents have a dismal prognosis. The mainstay therapy is hematopoietic cell transplantation (HCT), but there has been no innovation cytoreductive regimens. CP X-351, fixed 5:1 molar ratio of liposomal cytarabine to daunorubicin, shown favorable safety efficacy elderly individuals with secondary AML relapsed de novo AML. We report the outcomes 7 young patients (6 newly diagnosed sMDS/AML 1...
Abstract The transition period from pediatric care to adult for patients with sickle cell disease (SCD) is associated increased mortality and morbidity. Identification of risk factors unsuccessful may aid in developing strategies improve the process health outcomes this population. We examined SCD at Johns Hopkins Hospital. found that public insurance hospitalization rates were poor care. findings provide possible areas intervention.
Abstract Background Up to 10% of children are reported be allergic penicillin, but many allergy labels unverified and may require formal testing. Inaccurate drug associated with a range adverse clinical outcomes. Patients hematological disorders experience frequent severe infections; those who have been incorrectly labeled penicillin benefit from de‐labeling (ADL) efforts facilitate access beta‐lactam antibiotics. We developed multidisciplinary, pharmacist‐driven process that enabled...
Pure red cell aplasia (PRCA) is characterized by isolated anemia and a marked reduction or absence of erythroid precursors in the bone marrow. Depending on underlying etiology, treatment may include immunomodulation cytotoxic agents, chronic blood transfusions, hematopoietic stem transplantation. Parvovirus B19 infection well-recognized cause transient PRCA, typically resolving with viral clearance. We report an unusual late relapse PRCA occurring years after parvovirus eradication,...
ABSTRACT We propose two novel one‐sample Mendelian randomization (MR) approaches to causal inference from count‐type health outcomes, tailored both equidispersion and overdispersion conditions. Selecting valid single‐nucleotide polymorphisms (SNPs) as instrumental variables (IVs) poses a key challenge for MR approaches, it requires meeting the necessary IV assumptions. To bolster proposed by addressing violations of assumptions, we incorporate process removing invalid SNPs that violate In...
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Why put together a supplement on vascular anomalies for pediatric hematologists and oncologists? Over the past decade, role interests of hematologist/oncologists (PHOs) in has grown significantly. Along with this growth comes necessity PHO providers to learn current evidence best practices appropriately care individuals these conditions. The purpose collection papers was not meant as comprehensive review but rather an opportunity share practical focused guidance our colleagues who may...