A5022227314- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- COVID-19 and healthcare impacts
- Antifungal resistance and susceptibility
- Neutropenia and Cancer Infections
- Fungal Infections and Studies
- Neuroblastoma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Blood Coagulation and Thrombosis Mechanisms
- Family and Patient Care in Intensive Care Units
- Sinusitis and nasal conditions
- Cytomegalovirus and herpesvirus research
- Pneumocystis jirovecii pneumonia detection and treatment
- Autoimmune and Inflammatory Disorders Research
- Immunodeficiency and Autoimmune Disorders
- Infectious Diseases and Mycology
- Abdominal Trauma and Injuries
- Viral-associated cancers and disorders
- Dermatological and COVID-19 studies
- Polyomavirus and related diseases
- COVID-19 Impact on Reproduction
- Protein Degradation and Inhibitors
- Acute Myocardial Infarction Research
- Retinopathy of Prematurity Studies
Schneider Children's Medical Center
2016-2025
Tel Aviv University
2016-2024
Most children diagnosed with acute lymphoblastic leukemia (ALL) will achieve remission and be cured of their disease. However, this high cure rate comes at the cost chronic treatment-related toxicities. In fact, a similar number die from either ALL itself or toxicities associated its treatment. Therapy-related toxicities, whether chronic, can impact treatment efficacy, overall survival (OS), patient's quality life. This review focused on six major therapy, venous thromboembolism,...
COVID-19, the novel coronavirus has caused a global pandemic affecting millions of people around world. Although children, including children with cancer, have been found to be affected less commonly and severely than adults, indirect effects on diagnosis treatment cancer described. A survey was performed in four largest tertiary pediatric hematology-oncology medical centers Israel. Clinical laboratory data were collected from files patients diagnosed or treated during April–October 2020....
Abstract Tremendous progress in the therapy of pediatric acute lymphoblastic leukemia (ALL) has been achieved through combination cytotoxic chemotherapy, leading to high cure rates, at cost significant life‐threatening toxicity. The bispecific T‐cell engager blinatumomab, recently approved for relapsed/refractory ALL, a unique nonmyelotoxic toxicity profile. As blinatumomab causes B‐cell depletion, safety its use during severe chemotherapy‐induced is unclear. We report 11 patients with...
Data on management of pediatric marginal zone lymphoma (MZL) are scarce. This retrospective study assessed characteristics and outcome in 66 patients who were <18 years old. Forty-four (67%) had an extranodal MZL (EMZL), 21 (32%) a nodal (NMZL), one patient splenic MZL. Thirty-three (50%) received variable combination adjuvant chemotherapy/immunotherapy/radiotherapy, while the remainder, including 20 with NMZL, entered active observation period. Overall survival was excellent (98 ± 2%),...
Summary Mucormycosis has emerged as an increasingly important cause of morbidity and mortality in immunocompromised patients, but contemporary data children are lacking. We conducted a nationwide multicentre study to investigate the characteristics mucormycosis with haematological malignancies. The cohort included 39 mucormycosis: 25 1136 (incidence 2·2%) acute leukaemias prospectively enrolled centralized clinical registry 2004–2017, additional 14 malignancies identified by retrospective...
Summary Splenectomy is considered therapeutic in various non‐malignant haematologic diseases. Adverse events ‒ specifically infections and thromboembolism are not extensively documented the paediatric population, maintaining concern over risks‐versus‐benefits of procedure. We studied a cohort haematology patients undergoing splenectomy between 1977 2015 to determine short‐ long‐term complications. summarised all clinic our major Israeli tertiary centre for reasons, capturing infectious...
Summary This study investigated the prevalence of inherited thrombophilia, risk venous thromboembolism ( VTE ) and benefit low molecular weight heparin prophylaxis in 476 Israeli children with acute lymphoblastic leukaemia ALL treated between 2004 2016. Thrombophilia was found 15·5%. Arab had a higher F5 R506Q (factor V Leiden) than Jewish (19·4% vs. 2·9%, P < 0·01). Patients thrombophilia rates (26·5% 5·6%, 0·001). None thrombophilic given severe . Routine evaluation for followed by...
Background: Mucormycosis is a life-threatening infection with tendency for angioinvasion that may lead to progressive dissemination. Disseminated mucormycosis, defined as the involvement of two or more non-contiguous sites, rare in children, and data concerning its management outcome are scarce. The aim this study was assess contemporary strategies outcomes disseminated mucormycosis pediatric population. Methods: We conducted retrospective search six large tertiary medical centers all cases...
Venous thromboembolism (VTE) is a serious complication of acute lymphoblastic leukemia (ALL) therapy. The aim this population-based study was to evaluate the rate, risk factors, and long-term sequelae VTE in children treated for ALL. cohort included 1191 aged 1–19 years diagnosed with ALL between 2003–2018, prospectively enrolled two consecutive protocols: ALL-IC BFM 2002 AIEOP-BFM 2009. VTEs occurred 89 patients (7.5%). Long-term were uncommon. By univariate analysis, we identified four...
Summary Detection of somatic mutations may help verify the diagnosis myelodysplastic syndrome (MDS) in patients with persistent cytopenias or MDS‐predisposition syndromes, prior to development overt leukemia. However, spectrum and consequences acquired changes paediatric have not been fully evaluated, especially context an underlying syndrome. We incorporated a targeted next‐generation‐sequencing panel 54 genes for detection young adult inherited cytopenias. Sixty‐five were included this...
Acute invasive fungal rhinosinusitis has been associated with high mortality rates.We aimed to explore the contribution of novel detection and treatment methods on outcome immunosuppressed children acute rhinosinusitis.The records all a hematologic or oncologic disease who developed between 2005-2020 were reviewed.Thirty-four patients included. Aspergillosis mucormycosis diagnosed in 20 (59%) 12 (35%), respectively. Panfungal polymerase chain reaction (PCR) was change 36% patients. A more...
Osteonecrosis is a major cause of acute and long-lasting complications lymphoblastic leukemia (ALL) therapy in children. Our study aimed to evaluate the prevalence, characteristics, risk factors, outcome osteonecrosis children with ALL.The cohort included 559 aged 1-20 years diagnosed ALL between 2003 2018 at two tertiary medical centers Israel enrolled consecutive protocols: ALL-IC BFM 2002 AIEOP-BFM 2009. Symptomatic was prospectively captured as an adverse event.Osteonecrosis occurred 51...
Abstract Background Inflammatory manifestations (IM) are well described in adult patients with myelodysplastic syndrome (MDS), but the presentation is highly variable and no standardized treatment exists. This phenomenon rarely reported children. As more pediatric hematopoietic stem cell transplantation (HSCT) candidates, role of anti‐inflammatory relation to HSCT should be defined. Procedure Here, we report a series five children from tertiary center. We describe clinical presentation,...
Objectives: Acute invasive fungal rhinosinusitis has been associated with high mortality rates. We aimed to explore the contribution of novel detection and treatment methods on outcome immunosuppressed children acute rhinosinusitis. Design: Retrospective observational cohort study. Setting: A tertiary children’s hospital. Participants: The records all a hematologic or oncologic disease who developed AIFR between 2005-2020 were reviewed. Results: Thirty-four patients included. Aspergillosis...
Abstract Background Bacteremia complicates more than 50% of childhood Acute myeloid leukemia (AML) patients with predominantly Gram-positive cocci )GPC). Objectives Assess bacteremia rates, risk factors, causative organisms, and antibiotic resistance in Israeli children de-novo AML. Methods all chemotherapy courses for enrolled the standard arm NOPHO-DBH 2012 AML protocol were included. Down syndrome, myelodysplastic acute promyelocytic leukemia, secondary AML, isolated granulocytic sarcoma...
Since bacteremia complicates childhood Acute myeloid leukemia (AML) patients, we assessed rates in Israeli children with de-novo AML. All chemotherapy courses of patients enrolled NOPHO-DBH-2012 AML protocol were included. Down syndrome, acute promyelocytic excluded. Among 69 seven had focal bacterial infections. Of the remaining 62, 77.4% 1–8 bacteremias. 238 courses, 98 (41.2%) bacteremia: 66 (67.3%) predominantly Gram-negative rods (GNR); 28 (28.6%) Gram-positive cocci. Escherichia coli;...
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, yet data regarding long-term ovarian reserve of female survivors are limited. The aim this study was to investigate whether there a differential pattern anti-Mullerian hormone (AMH) levels in ALL compared with normal age-matched population. In cohort 56 (median age 29 years; median follow-up 20.6 years), negative correlation found between at diagnosis and age-adjusted (r = −0.334, p .031). Despite alkylating agent...
Summary Most childhood acute lymphoblastic leukaemia (ALL) protocols include high‐dose steroid therapy. However, the known potential of steroids to significantly elevate intraocular pressure (IOP) and lead glaucomatous optic neuropathy has not been intensively investigated in children with ALL. Moreover, as ALL do routinely undergo IOP measurements, need for monitoring therapy is unknown. We prospectively measured 90 newly diagnosed attending a tertiary paediatric haematology/oncology...
Summary Steroids are a mainstay in the treatment of acute lymphoblastic leukaemia (ALL) children and adolescents; however, their use can cause clinically significant steroid‐related neuropsychiatric symptoms (SRNS). As current knowledge on SRNS during ALL is limited, we mapped phenotypes, occurrence strategies using database created by international Ponte di Legno Neurotoxicity Working Group including data toxicity central nervous system (CNS) patients treated with frontline protocols...
Background and aims: Nucleophosmin 1 (NPM1) mutations are found in 30% of adult AML associating with a favorable outcome, while they less frequent pediatric (5-8%). There is limited data on the prevalence clinical significance NPM1 children myelodysplastic syndrome excess blasts (MDS-EB) Methods: Between 07/1998 06/2021, 322 patients (<18 years) MDS-EB were registered EWOG-MDS-98/2006 studies. Targeted next generation sequencing for somatic aberrations as well molecular analysis germline...