A5068767150- Ferroptosis and cancer prognosis
- Heat shock proteins research
- Extracellular vesicles in disease
- Endoplasmic Reticulum Stress and Disease
- RNA modifications and cancer
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Hepatitis B Virus Studies
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Melanoma and MAPK Pathways
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Autophagy in Disease and Therapy
- COVID-19 and healthcare impacts
- Protein Kinase Regulation and GTPase Signaling
- Reproductive Biology and Fertility
- Fungal and yeast genetics research
- Cancer Risks and Factors
- Radiomics and Machine Learning in Medical Imaging
- Viral-associated cancers and disorders
- Colorectal Cancer Treatments and Studies
- COVID-19 Clinical Research Studies
Rambam Health Care Campus
2019-2023
Technion – Israel Institute of Technology
2021-2023
Rabin Medical Center
2017-2020
Hebrew University of Jerusalem
2015-2016
The efficacy and safety profile of SARS-CoV-2 vaccines have been acquired from phase 3 studies; however, patients with cancer were not represented in these trials. Owing to the recommendation prioritize high-risk populations for vaccination, further data are warranted.To evaluate use BNT162b2 vaccine undergoing treatment cancer.In January 2021, mass vaccination populations, including cancer, was initiated Israel. This cohort study prospectively enrolled followed up healthy participants...
Gastric cancer is the third most lethal worldwide, and evaluation of genomic status gastric cells has not translated into effective prognostic or therapeutic strategies. We therefore hypothesize that outcomes may depend on tumor microenvironment (TME), in particular, cancer-associated fibroblasts (CAF). However, very little known about role CAFs cancer. To address this, we mapped transcriptional landscape human stroma by microdissection RNA sequencing from patients with A stromal gene...
Abstract We had previously reported short-term efficacy, immunogenicity, and safety of the BNT162b2 vaccine among cancer patients with solid tumors. aimed to evaluate these outcomes at six months postvaccination. The study cohort comprised who were on treatment during vaccination throughout Serologic tests performed after second afterward. An age-matched health care workers served as controls. Documentation COVID-19 infection, blood tests, imaging studies period was reviewed. Participants...
The receptor-tyrosine kinase (RTK)/Ras/Raf pathway is an essential cascade for mediating growth factor signaling. It abnormally overactive in almost all human cancers. downstream targets of the are members extracellular regulated kinases (Erk1/2) family, suggesting that this family a mediator oncogenic capability cascade. Although mutations result strong activation Erks, activating Erks themselves were not reported Here we used spontaneously active Erk variants to check whether Erk's...
Abstract Objective Gastric cancer (GC) is a leading cause of death, occurs predominantly in older age, with increasing incidence young patients. The Cancer Genome Atlas indicates four subtypes for GC among which Epstein-Barr virus (EBV) subtype estimated at 8.7%. We aim to determine the prevalence EBV patients (≤45 years) compared an average-onset cohort (≥55 and characterize clinicopathologic pattern young-onset GC. Methods samples both cohorts were screened by qPCR. Additional staining was...
<b><i>Background/Aims:</i></b> Current chemotherapy regimens for cholangiocarcinoma (CCA) yield poor outcomes, with a median overall survival of &#x3c;12 months. Recent data on the genomic landscape CCAs have created opportunities targeted therapy. Yet, regarding its efficacy are scarce. We aimed to describe CCA patient cohort using next-generation sequencing (NGS), focusing ERBB/EFGR pathway and assessing response anti-HER2 agents....
Background The incidence of early-onset colorectal cancer (EOCRC) rose abruptly in the mid 1990s, is continuing to increase, and has now been noted many countries. By 2030, 25% American patients diagnosed with rectal will be 49 years or younger. large majority EOCRC cases are not found germline susceptibility mutations (eg, Lynch syndrome) inflammatory bowel disease. Thus, environmental lifestyle factors suspected drivers. Obesity, sedentary lifestyle, diabetes mellitus, smoking, alcohol,...
IntroductionDigital social networks have become a key player in the ecosystem of young patients with cancer, regard to their unique perspectives and unmet needs. This study aims investigate web-based community tools characterise user profile, needs goals cancer.MethodsA survey was distributed via large-scale network designated for cancer (age 18–45 years) Stop Cancer. The collected demographic data oncological status. Primary outcome potential accessing network; secondary outcomes were...
Background: Trastuzumab, a humanized anti-human epidermal growth factor receptor 2 (HER2/neu) antibody, is considered standard treatment in addition to chemotherapy the adjuvant setting for HER2/neu-positive breast cancer, yet its impact on fertility and ovarian reserve remains obscure. We aimed study effect of anti-HER2/neu chemotherapy-induced toxicity both clinical preclinical settings. Methods: prospectively enrolled cancer patients below age 42 years who were treated with or without...
(1) Background: We aimed to explore the association between neoadjuvant treatment, tumor-infiltrating immune lymphocyte (TIL), and tumor-associated macrophage (TAM) survival in patients with esophageal adenocarcinoma. (2) Methods: Patients who underwent esophagectomy were divided into three groups according their treatment modality tumor regression grade (TRG): (i) surgery-only group (SG), (ii) good responders (GR) (TRG 0−1), (iii) bad (BR) 2−3). then carried out statistical correlations of...
Breast cancer is diagnosed in ~0.3% of pregnant women. Studies that have addressed gestational and neonatal outcomes chemotherapy during pregnancy demonstrated increased complications including preeclampsia intrauterine growth retardation. We hypothesized anthracycline-induced could be derived from direct toxicity on the placenta vasculature. Pregnant ICR mice (day E12.5) were treated with doxorubicin (DXR; 8 mg/kg) or saline, while their umbilical cord blood flow was imaged by pulse-wave...
Abstract Background The coronavirus disease 2019 (COVID‐19) crisis and consequent changes in medical practice have engendered feelings of distress diverse populations, potentially adversely affecting the psychological well‐being cancer patients. Aim purpose this observational longitudinal study was to evaluate psychosocial perspectives among patients with on intravenous treatment during COVID‐19 pandemic. Methods results recruited 164 undergoing anti‐neoplastic therapy a tertiary center....
MAP kinases of the ERK family are conserved from yeast to humans. Their catalytic activity is dependent on dual phosphorylation their activation loop's TEY motif, catalyzed by MAPK (MEKs). Here we studied variants Mpk1, a orthologue Erk, which essential for cell wall integrity. Cells lacking MPK1, or genes encoding relevant MEKs, MKK1 and MKK2, do not proliferate under stress, imposed, example, caffeine. Mutants Mpk1(Y268C) Mpk1(Y268A), function independently Mkk1 Mkk2. We show that these...
Background: The risk of cancer patients to develop COVID19 infection is unclear. We aimed prospectively study and oncology healthcare workers for serology. In IgG+ cases, immune profile was determined portray the pattern response SARS-CoV2. Methods: Cancer on active treatment were enrolled. During period (3/2020-6/2020), demographic data blood collected at three time points. Expression IgG, IgM, IgA assessed. SARS-CoV-2 cases matched negative we performed mass cytometry flight (CyTOF)...
Abstract Background Anatomic location of primary tumors across the colon correlate with survival in metastatic setting, whereas left-sided may exhibit superior compared right-sided tumors. The Oncotype Recurrence Score (RS) assay is a clinically validated predictor recurrence risk patients stage II colorectal cancer (CRC). Previous studies had indicated that without adjuvant chemotherapy, CDX2-negative CRC are associated lower rate disease-free than CDX2-positive We aimed to evaluate whether...
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, yet data regarding long-term ovarian reserve of female survivors are limited. The aim this study was to investigate whether there a differential pattern anti-Mullerian hormone (AMH) levels in ALL compared with normal age-matched population. In cohort 56 (median age 29 years; median follow-up 20.6 years), negative correlation found between at diagnosis and age-adjusted (r = −0.334, p .031). Despite alkylating agent...
Abstract Background Esophageal cancer represents a global challenge. Despite significant evolution of treatment protocols in the past decade, recurrence rates are still high and survival poor. Current paradigm for localized gastroesophageal junction (GEJ) carcinoma remains to be further elucidated as role neoadjuvant chemoradiation versus perioperative chemotherapy. Aim To identify biomarkers response esophageal cancer, we performed an in‐depth proteomic analysis tumors, describe differences...
523 Background: Recent evidence indicate that the anatomic location of primary tumors across colon correlate with survival in metastatic setting, whereas left-sided may exhibit superior compared right-sided. The Oncotype DX, a 12-gene cancer assay, is clinically validated predictor recurrence risk stage II colorectal (CRC) patients. Previous studies had indicated CDX2-negative are often associated several adverse prognostic variables. Recently, it has been shown without adjuvant...
<p>This file contains Supplementary Materials and Methods, Figure Legends, 6 Figures with their legends</p>