A5048648188- Sinusitis and nasal conditions
- Head and Neck Surgical Oncology
- Ear and Head Tumors
- Nasal Surgery and Airway Studies
- Ear Surgery and Otitis Media
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Head and Neck Cancer Studies
- Cancer-related molecular mechanisms research
- Salivary Gland Tumors Diagnosis and Treatment
- Antifungal resistance and susceptibility
- Facial Nerve Paralysis Treatment and Research
- Cervical Cancer and HPV Research
- Infectious Diseases and Mycology
- Cancer-related gene regulation
- Nasolacrimal Duct Obstruction Treatments
- Pituitary Gland Disorders and Treatments
- Bone Tumor Diagnosis and Treatments
- Cancer Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Thyroid Cancer Diagnosis and Treatment
- Meningioma and schwannoma management
- Cancer Genomics and Diagnostics
- Cutaneous lymphoproliferative disorders research
- Gastric Cancer Management and Outcomes
Tel Aviv University
2016-2025
Rabin Medical Center
2016-2025
Schneider Children's Medical Center
2016-2019
Johns Hopkins University
2010-2017
Johns Hopkins Medicine
2010-2017
University of Baltimore
2010-2017
Stanford University
2012-2016
Stanford Medicine
2013-2014
Bridge University
2014
Indiana University School of Medicine
2012
Objectives/Hypothesis To analyze complications associated with nasoseptal flap elevation and reconstruction in endoscopic skull base surgery. Study Design Case series. Methods Retrospective chart review of all patients who underwent procedure our institution between 2008 2013. Results A total 121 were identified a mean follow‐up time 10.4 months. Complications this occurred 33 (27%). The majority related to the septal donor site included perforation, cartilage necrosis, prolonged crusting....
This study aimed to assess sinonasal outcomes in patients with aspirin exacerbated respiratory disease (AERD) undergoing desensitization following endoscopic sinus surgery (ESS).Case series chart review.University hospital.A retrospective review of was conducted for 30 AERD and maintenance therapy ESS. Sinonasal were prospectively assessed by the Outcomes Test-22 (SNOT-22) polyp grading system. Data collected preoperatively, 1 4 weeks postsurgery (before desensitization), 1, 6, 12, 18, 24,...
Abstract Mitochondrial DNA (mtDNA) mutations were reported in different cancers. However, the nature and role of mtDNA mutation never‐smoker lung cancer patients including with epidermal growth factor receptor ( EGFR ) KRAS gene are unknown. In present study, we sequenced entire mitochondrial genome (16.5 kb) matched normal tumors obtained from 30 current‐smoker patients, determined content. All patients' samples for (exon 2) 19 21) mutation. The impact forced overexpression a respiratory...
Although the safety of topical nasal steroids is well established for spray forms, data regarding steroid irrigations limited. We studied effect long-term budesonide (>6 months) on hypothalamic-pituitary-adrenal axis (HPAA) function and intraocular pressure (IOP) in patients post-endoscopic sinus surgery.This was retrospective case series. Adrenal assessed by using high-dose cosyntropin stimulation test.A total 48 were assessed, with a mean duration 22 months. Stimulated cortisol levels...
<h3>Objective</h3> To compare the characteristics and prognosis of patients with malignant (necrotizing) external otitis (MEO) without facial nerve palsy in today's era third-generation antibiotics. <h3>Design</h3> Comparative retrospective case series. <h3>Setting</h3> Department Otolaryngology–Head Neck Surgery, Rabin Medical Center, a tertiary care medical center. <h3>Patients</h3> Forty-eight MEO diagnosed treated from 1990 to 2004. Eight had paralysis 40 normal function. <h3>Main...
To assess the possible effect of young age on clinical behaviour and survival outcome squamous cell carcinoma oral tongue.Retrospective, case control study.A major tertiary referral centre.Eighty-five patients with tongue at least 2 years follow-up.Clinical histopathological staging, disease-free survival, disease-specific overall survival.Eleven (13%) were younger than 30 years. Compared to older patients, they had a significantly worse N stage (P = 0.041), more perineural invasion 0.012),...
To study the effect of specific clinical, laboratory, and imaging parameters on course severe (type 1) malignant external otitis (MEO).Case series with chart review.Tertiary, university-affiliated medical center.Fifty-seven patients hospitalized MEO were followed for disease survival in a tertiary center between 1990 2008.In 20% patients, was persistent and/or aggressive despite prolonged extensive treatment. Of this subgroup, 45% died disease. Prognostic factors persistent/aggressive facial...
Obstructive sleep apnea (OSA) is a common disorder, characterized by cyclic cessation of airflow for 10 seconds or more. There growing awareness that OSA related to the development and progression cardiovascular disease. However, only few studies have associated directly major events. The aim this study was evaluate relationship between morbidity in well defined population patients.The electronic database central district health management organization searched all patients diagnosed with...
Object In this study the authors share their experience using intraoperative spinal navigation and imaging for endoscopic transnasal approaches to odontoid in 5 patients undergoing C1–2 surgery basilar invagination at Stanford Hospital Clinics from 2010 2013. Methods Of these invagination, 4 underwent a 2-tiered anterior resection with posterior occipitocervical fusion during first stage surgery, followed by endonasal odontoidectomy separate setting. Intraoperative stereotactic was performed...
Methylation alterations of CpG islands, island shores and first exons are key events in the formation progression human cancer, an increasing number differentially methylated regions genes have been identified breast cancer. Recent studies cancer methylome using deep sequencing microarray platforms providing a novel insight on different roles aberrant methylation plays molecular subtypes Accumulating evidence from subset suggests that promoter tumor-suppressor associated with can be...
Orbital complications of rhinosinusitis in adults are scarcely discussed the literature.To review our experience with management orbital adult patient population and identify key factors characteristics these patients.Retrospective case series during years 2004 to 2016 a tertiary referral center including all patients complications.Severity complications, risk factors, clinical, imaging microbiological data, treatment outcomes.Seventy were identified. Median age at diagnosis was 38 years. In...
Objectives: Preoperative maxillary sinus imaging findings have been suggested to be associated with complications and outcomes of lift dental implant procedures; nonetheless the evidence is controversial. The aim this study was examine association between preoperative procedures in asymptomatic patients. Methods: We included all patients who underwent 2014 2017. Maxillary were extracted from pre-procedural computed tomography scans, assessed. Results: A total 145 included. No sinonasal...
// Francesca Pirini 1, * , Sassan Noazin 2, Martha H. Jahuira-Arias 3, 4, Sebastian Rodriguez-Torres 3 Leah Friess Christina Michailidi Jaime Cok 5 Juan Combe 6 Gloria Vargas 7 William Prado 8 Ethan Soudry Jimena Pérez Tikki Yudin Andrea Mancinelli Helen Unger Carmen Ili-Gangas 9, 10 Priscilla Brebi-Mieville Douglas E. Berg 11, 12 Masamichi Hayashi 13 David Sidransky Robert Gilman 4 Rafael Guerrero-Preston 14 1 Biosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura...
Cervical cancer is a major health concern among women in Latin America due to its high incidence and mortality. Therefore, the discovery of molecular markers for cervical screening triage imperative. The aim this study was use genome wide DNA methylation approach identify novel biomarkers cancer. from normal mucosa tissue samples Chile enriched with Methylated Immunoprecipitation (MeDIP), hybridized oligonucleotide microarrays analyzed stringent bioinformatics pipeline differentially...
Purpose Prior studies have demonstrated tumor-specific alternative splicing events in various solid tumor types. The role of the development and progression head neck squamous cell carcinoma (HNSCC) is unclear. Our study queried exon-level expression to implicate splice variants HNSCC tumors. Experimental Design We performed a comparative genome-wide analysis 44 tumors 25 uvulopalatopharyngoplasty (UPPP) tissue samples at an exon level. In our comparison we ranked genes based upon novel...
Objective The clinical presentation of sphenoid sinusitis can be highly variable. Rarely, may present with cranial nerve complications due to the proximity these structures sinus. Method A case series from Rabin Medical Center and all cases nerves palsies secondary that have been reported in literature were reviewed. Results Seventeen patients identified. abducent was most common affected (76%), followed by oculomotor (18%). One patient had combined oculomotor, trochlear palsies. pathology...
Objective/Hypothesis Anticoagulant and antiplatelet medications (ACAP) are known to be associated with an increased risk for epistaxis. There conflicting results regarding the impact of Novel Oral Anticoagulants (NOAC) on epistaxis its severity. Study Design Retrospective chart review patients who were admitted ED in our tertiary level hospital a diagnosis during years 2012 2018. Methods analysis presenting emergency otolaryngological care The various ACAP severity, admission, recurrence was...