A5008000581- Sinusitis and nasal conditions
- Head and Neck Surgical Oncology
- Nasal Surgery and Airway Studies
- Allergic Rhinitis and Sensitization
- Mycobacterium research and diagnosis
- Oral microbiology and periodontitis research
- Nasolacrimal Duct Obstruction Treatments
- Meningioma and schwannoma management
- Bacterial biofilms and quorum sensing
- Asthma and respiratory diseases
- Infectious Diseases and Mycology
- Bacteriophages and microbial interactions
- Pituitary Gland Disorders and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Microbial infections and disease research
- Oral and Maxillofacial Pathology
- Surgical Simulation and Training
- Pediatric health and respiratory diseases
- Olfactory and Sensory Function Studies
- Inhalation and Respiratory Drug Delivery
- Gut microbiota and health
- Immune Response and Inflammation
- Antimicrobial Peptides and Activities
- Otolaryngology and Infectious Diseases
- Respiratory and Cough-Related Research
Basil Hetzel Institute
2016-2025
The University of Adelaide
2016-2025
Queen Elizabeth Hospital
2016-2025
Queen Elizabeth Hospital Birmingham
2017-2025
Central Adelaide Local Health Network
2020-2024
Royal Adelaide Hospital
2014-2024
Health Net
2023
Women's and Children's Health Network
2022
Roche (France)
2019
RELX Group (Netherlands)
2019
Abstract Summary In recent years, there has been an increasing interest in bacteriophages, which led to growing numbers of bacteriophage genomic sequences becoming available. Consequently, is a need for rapid and consistent annotation tool dedicated bacteriophages. Existing tools either are not designed specifically bacteriophages or web- email-based require significant manual curation, makes their integration into bioinformatic pipelines challenging. Pharokka was created provide that...
Objectives/Hypothesis To compare three existing endoscopic scoring systems and a newly proposed modified system for the assessment of patients with chronic rhinosinusitis (CRS). Study Design Blinded, prospective cohort study. Methods CRS completed two patient‐reported outcome measures (PROMs)—the visual analogue scale (VAS) symptom score Sino‐Nasal Outcome Test‐22 (SNOT‐22)—and then underwent standardized, recorded sinonasal endoscopy. Videos were scored by blinded rhinologists using...
The frontal recess and sinus anatomy can vary from simple to complex. variations in the of are considerable but almost all be classified if various cell patterns analyzed. This consensus document was developed improve ability surgeon understand these possible variations, plan surgery, communicate complexities when teaching or reporting outcomes. Once understands anatomical pattern cells, extent surgery planned. presents a classification based on classification.
Background Although the existence of biofilms on sinus mucosa patients with chronic rhinosinusitis (CRS) is now well established, role that these structures play remains unclear. It thought may contribute to recalcitrant and persistent nature characterizes CRS, but little research exists documenting effect they have postoperative mucosal outcomes. This article presents a retrospective analysis surgical correlates presence study was performed evaluate bacterial post-sinus Methods A...
The recent detection of bacterial biofilms on the sinus mucosa patients with chronic rhinosinusitis (CRS) has implicated in pathogenesis this condition. Electron microscopy been main modality used to document presence tissue, however, it inherent problems associated tissue preparation and sampling. Recently, Confocal Scanning Laser Micrsocopy (CSLM) emerged as a noninvasive, nondestructive technique for analysis biofilms. This study CSLM means investigating biofilm CRS patients.A prospective...
Conclusive evidence exists that biofilms are present on the mucosa of chronic rhinosinusitis (CRS) patients. Less is known about species constituting these biofilms. This study developed a fluorescence in situ hybridization (FISH) protocol for characterization bacterial and fungal CRS.Fifty CRS patients 10 controls were recruited. Bacteria FISH probes Staphylococcus aureus, Haemophilus influenzae, Pseudomonas aeruginosa universal probe fungi applied to sinus mucosal specimens then analyzed...
<h3>Importance</h3> <i>Staphylococcus aureus</i>infections are associated with recalcitrant chronic rhinosinusitis (CRS). The emerging threat of multidrug-resistant<i>S has revived interest in bacteriophage (phage) therapy. <h3>Objective</h3> To investigate the safety, tolerability, and preliminary efficacy ascending multiple intranasal doses investigational phage cocktail AB-SA01 patients CRS due to<i>S aureus</i>. <h3>Design, Setting, Participants</h3> This phase 1, first-in-humans,...
Background Although biofilms have been implicated in the pathogenesis of chronic rhinosinusitis (CRS), there is little evidence that their presence or absence has any effect on outcomes endoscopic sinus surgery (ESS). The aim this study was to investigate postsurgical after ESS. Methods A prospective, blinded 51 consecutive patients undergoing ESS for CRS conducted. Preoperatively, assessed symptoms using internationally accepted standardized symptom scoring systems and quality-of-life (QOL)...
Introduction: Pseudomonas aeruginosa infections are prevalent amongst chronic rhinosinusitis (CRS) sufferers. Many P. strains form biofilms, leading to treatment failure. Lytic bacteriophages (phages) viruses that infect, replicate within, and lyse bacteria, causing bacterial death. Aim: To assess the activity of a phage cocktail in eradicating biofilms ex vivo isolates from CRS patients. Methods: patients with without cystic fibrosis (CF) across three continents were multi-locus sequence...
To cite this article: Foreman A., Holtappels G., Psaltis A.J., Jervis‐Bardy J., Field Wormald P.‐J., Bachert C. Adaptive immune responses in Staphylococcus aureus biofilm–associated chronic rhinosinusitis. Allergy 2011; 66 : 1449–1456. Abstract Background: The etiopathogenesis of rhinosinusitis (CRS) is currently an area intense debate. Recently, biofilms have been proposed as a potential environmental trigger disease. In particular, appear to be predictor severe disease recalcitrant current...
Objectives/Hypothesis To analyze complications associated with nasoseptal flap elevation and reconstruction in endoscopic skull base surgery. Study Design Case series. Methods Retrospective chart review of all patients who underwent procedure our institution between 2008 2013. Results A total 121 were identified a mean follow‐up time 10.4 months. Complications this occurred 33 (27%). The majority related to the septal donor site included perforation, cartilage necrosis, prolonged crusting....
Chronic rhinosinusitis (CRS) is a prevalent inflammatory condition that substantially affects patients' quality of life. Functional endoscopic sinus surgery (FESS) commonly performed in cases where medical therapy fails. Effective post-operative drug delivery crucial for improving outcomes. This study uses computational fluid dynamics (CFD) to compare nebulisation and nasal irrigation (bottle wash) sinonasal models evaluate how anatomical alterations affect deposition across various...
To examine the efficacy and tolerability of topical mupirocin for management surgically recalcitrant chronic rhinosinusitis (CRS) associated with Staphylococcus aureus infection.Prospective open-label pilot study.Patients CRS who had positive nasendoscopically guided cultures were treated twice daily nasal lavages containing 0.05% Mupirocin lactated ringers salts. The duration treatment was 3 weeks. Patients assessed before after in terms nasendoscopic findings, microbiology results,...
This study aimed to assess sinonasal outcomes in patients with aspirin exacerbated respiratory disease (AERD) undergoing desensitization following endoscopic sinus surgery (ESS).Case series chart review.University hospital.A retrospective review of was conducted for 30 AERD and maintenance therapy ESS. Sinonasal were prospectively assessed by the Outcomes Test-22 (SNOT-22) polyp grading system. Data collected preoperatively, 1 4 weeks postsurgery (before desensitization), 1, 6, 12, 18, 24,...
Abstract Objectives/Hypothesis: Chronic rhinosinusitis (CRS) recalcitrant to surgery is a frustrating clinical entity. Recently, mupirocin sinonasal rinses have been suggested as an efficacious treatment alternative in these patients where Staphylococuccus aureus infection demonstrated. To our knowledge, how best treat this S reservoir has not previously evaluated double‐blinded, randomized, placebo‐controlled trial. Study Design: Prospective, study. Methods: Twenty‐five ‐positive CRS with...
Background In patients undergoing transnasal endoscopic sellar surgery, an analysis of risk factors and predictors intraoperative postoperative cerebrospinal fluid leak (CSF) would provide important prognostic information. Methods A retrospective review surgery for pituitary adenomas or craniopharyngiomas between 2002 2014 at 7 international centers was performed. Demographic, comorbidity, tumor characteristics were evaluated to determine the associations CSF leaks. Correlations...
Objectives/Hypothesis Compare cytokine levels in sinus tissue to secretions from controls and chronic rhinosinusitis patients. Study Design In vitro. Methods Polyurethane foam sponges were placed into middle meati of patients with without nasal polyps (CRSsNP), (CRSwNP), controls. Sinus biopsies then taken the same location. Protein tumor necrosis factor‐alpha (TNF‐α), interferon‐γ (IFN‐γ), interleukins (IL) 2, 4, 6, 8, 10, 17A measured via cytometric bead assay for each sample. values...
Background Patients with aspirin‐exacerbated respiratory disease (AERD) and chronic rhinosinusitis nasal polyps (CRSwNP) are often reported to be recalcitrant standard medical surgical intervention. Failure rates of endoscopic sinus surgery in these patients as high 90%. We review the outcomes for our cohort AERD undergoing modified Lothrop procedure (EMLP). Methods Data was collected prospectively between January 2001 December 2013. Information including demographics, asthma status, aspirin...