A5055103078- Estrogen and related hormone effects
- Reconstructive Facial Surgery Techniques
- Facial Nerve Paralysis Treatment and Research
- Nasal Surgery and Airway Studies
- Ear Surgery and Otitis Media
- Ear and Head Tumors
- Cleft Lip and Palate Research
- Head and Neck Surgical Oncology
- Sinusitis and nasal conditions
- Facial Rejuvenation and Surgery Techniques
- Reconstructive Surgery and Microvascular Techniques
- Facial Trauma and Fracture Management
- Digital Imaging in Medicine
- Surgical Sutures and Adhesives
- Genomics and Chromatin Dynamics
- Allergic Rhinitis and Sensitization
- BRCA gene mutations in cancer
- Gene expression and cancer classification
- Craniofacial Disorders and Treatments
- Hair Growth and Disorders
- Nutrition, Genetics, and Disease
- Cancer and Skin Lesions
- Tumors and Oncological Cases
- Social Media in Health Education
- Computational Drug Discovery Methods
University of Virginia
2020-2025
University of Virginia Health System
2023-2025
Wake Forest University
2024
University of Virginia Medical Center
2022-2023
Medical University of South Carolina
2012-2020
State of Illinois
2020
Charleston Hematology Oncology Associates
2013
Indiana University School of Medicine
2006-2009
Indiana University – Purdue University Indianapolis
2009
Indiana University Bloomington
2006
Abstract The development of targeted therapies for antiestrogen-resistant breast cancer requires a detailed understanding its molecular characteristics. To further elucidate the events underlying acquired resistance to antiestrogens tamoxifen and fulvestrant, we established drug-resistant sublines from single colony hormone-dependent MCF7 cells. These model systems allowed us examine cellular changes induced by in context uniform clonal background. Global both basal estrogen-induced gene...
Objectives/Hypothesis Compare cytokine levels in sinus tissue to secretions from controls and chronic rhinosinusitis patients. Study Design In vitro. Methods Polyurethane foam sponges were placed into middle meati of patients with without nasal polyps (CRSsNP), (CRSwNP), controls. Sinus biopsies then taken the same location. Protein tumor necrosis factor‐alpha (TNF‐α), interferon‐γ (IFN‐γ), interleukins (IL) 2, 4, 6, 8, 10, 17A measured via cytometric bead assay for each sample. values...
To determine the impact of age on disease-specific survival in differentiated thyroid cancer.Retrospective analysis a large population database. Setting Surveillance, Epidemiology, and End Results (SEER) database/multiple settings.The SEER database was examined to identify patients diagnosed with either papillary or follicular carcinoma between years 1988 2003. Information obtained included patient age, sex, tumor type, size, extension, nodal distant metastases. Kaplan-Meier analyses were...
Facial paralysis affects patients' physical, social, and psychological function. Dynamic smile reanimation can mitigate these effects, but there are limited data to guide the surgeon in selecting best procedure for each patient.To compare quantitative changes oral commissure symmetry excursion following temporalis tendon transfer (T3) gracilis free muscle transfer.Retrospective case series of 28 adults with unilateral facial seeking dynamic lower at a tertiary academic medical center between...
Objective Giant basal cell carcinoma (GBCC) of the face is a rare, disfiguring entity with poorly understood psychological challenges and factors contributing to social isolation. This study evaluates reasons for delays in care this patient population. Methods A retrospective review patients GBCC (>5 cm) treated at tertiary academic center from January 2003 May 2024 was conducted. The clinical course, time presentation, insurance type, geographic were analyzed identify causes delay....
ABSTRACT Failure to recognize concomitant ocular injury in orbital fracture patients is a feared consequence of evaluation the acute setting. These injuries and their accompanying functional sequelae range severity, reconstructive surgeons need be sensitive possibility major that could potentially have serious outcomes. Indications for specialty‐trained ophthalmology with fractures remain controversial, some advocating an immediate comprehensive every patient fracture. In many institutions,...
Although the Reflux Symptom Index (RSI) is a validated laryngopharyngeal reflux (LPR) outcomes tool, its predictive value for LPR controversial. Because psychiatric problems may lead to exaggerated patient-perceived symptoms and RSI values,the aim of this study was determine whether positive pH probe-documented influenced by anxiety depression.We reviewed charts all patients who underwent probe testing between January 2006 July 2008 at our institution. The RSI, Finding Score (RFS), medical...
Background Chronic rhinosinusitis (CRS) is characterized by inflammatory cell migration into sinus tissue with resultant inflammation fueled a milieu of cytokines. Fibroblasts may contribute to through expression leukocyte adhesion molecules such as vascular molecule (VCAM) and intercellular (ICAM). VCAM attracts eosinophils mast cells contributing Th2 skewing, ICAM neutrophils lesser degree, eosinophils, contributes mixed Th1/Th2 skewing. The purpose this study was compare fibroblast ex...
Rhinoplasty is one of the most common cosmetic surgical procedures performed globally. Twitter, also known as "X," used by both patients and physicians has been studied a useful tool for analyzing trends in healthcare. The public social media discourse rhinoplasty not previously reported field otolaryngology. goal this study was to characterize user type, sentiment, temporal discussion on Twitter guide facial plastic surgeons their clinical practices.
The Millard rotation-advancement flap has become the most widely used technique for unilateral cleft lip repair. philtral ridge repair is a modified straight-line that was developed to further optimize scar associated with flap. purpose of this article introduce and objectively compare outcomes these two techniques.Two senior board-certified surgeons, who are active members their respective craniofacial teams, use different surgical techniques lip: repairs. authors retrospectively analyzed...
Determine the impact of adenoid size and prior adenoidectomy on outcomes sphincter pharyngoplasty.Retrospective review.Retrospective review patients 18 years age or younger, who underwent pharyngoplasty for velopharyngeal insufficiency (VPI) from 2007 to 2012. Nasal endoscopy nasometry testing were administered pre- postoperatively. Preoperative was scored by two blinded otolaryngologists. Primary outcome measures revision rate, achievement normal resonance, degree improvement in...
Introduction: Patients with facial paralysis have increased psychosocial distress, which affects overall quality of life (QOL). Objective: To evaluate the relationship between QOL and severity among patients subclinical anxiety and/or depression. Methods: were screened for depression using Generalized Anxiety Disorder-2 Patient Health Questionnaire-2 surveys. scores (Facial Clinimetric Evaluation) (House-Brackmann [HB] Sunnybrook [SB]) collected. a mental health diagnosis or treatment...
Abstract Background In an era of widespread Internet access, patients increasingly look online for health information. Given the frequency with which cosmetic botulinum toxin injection is performed, there a need to provide high-quality information about this procedure. Objectives The aim study was examine quality printed education materials (POEMs) toxin. Methods An search performed identify 32 websites various authorship types. Materials were evaluated accuracy and inclusion key content...
Nasal reconstruction following a total or subtotal resection presents challenging clinical scenario. Ample external skin coverage is readily available using the paramedian forehead flap (PMFF), but restoring adequate internal lining of sufficient size and pliability major limitation. Intranasal mucosal flaps free tissue transfer often employed for this purpose, each with their own sets limitations. Prelamination PMFF graft prior to method create composite both lining. Another challenge in...
Facial fractures are frequently assessed by the practicing otolaryngologist. All injuries with signs of active infection warrant antimicrobial therapy. However, there is a significant variability regarding use prophylactic antibiotics in cases mid-facial and upper facial third fractures. The current literature on this topic was, therefore, reviewed to better guide management these injuries. A search was conducted via PubMed Cochrane Library using keywords including "mid-face," "trauma,"...