A5101439338- Immune cells in cancer
- Histone Deacetylase Inhibitors Research
- Chemokine receptors and signaling
- Prostate Cancer Treatment and Research
- Cancer, Stress, Anesthesia, and Immune Response
- Genomics and Chromatin Dynamics
- Retinoids in leukemia and cellular processes
- DNA Repair Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Blood Coagulation and Thrombosis Mechanisms
- Genetics and Neurodevelopmental Disorders
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Hormonal and reproductive studies
Università della Svizzera italiana
2023-2024
Institute of Oncology Research
2023-2024
Third Affiliated Hospital of Southern Medical University
2024
University of Lausanne
2023
Cellular senescence can exert dual effects in tumors, either suppressing or promoting tumor progression. The senescence-associated secretory phenotype (SASP), released by senescent cells, plays a crucial role this dichotomy. Consequently, the clinical challenge lies developing therapies that safely enhance cancer, favoring tumor-suppressive SASP factors over tumor-promoting ones. Here, we identify retinoic-acid-receptor (RAR) agonist adapalene as an effective pro-senescence compound prostate...
Abstract Androgen deprivation therapy (ADT) is a standard for prostate cancer (PCa). Though disseminated disease initially sensitive to ADT, an important fraction of the patients progresses castration-resistant (CRPC). For this reason, identification novel effective therapies treating CRPC needed. Immunotherapeutic strategies focused on macrophages as antitumor effectors, directly enhancing their tumoricidal potential at tumor microenvironment or adoptive transfer after ex vivo activation,...
Quiescence (G0) maintenance and exit are crucial for tissue homeostasis regeneration in mammals. Here, we show that methyl-CpG binding protein 2 (Mecp2) expression is cell cycle-dependent negatively regulates quiescence cultured cells an injury-induced liver mouse model. Specifically, acute reduction of Mecp2 required efficient as deletion accelerates, while overexpression delays exit, forced after conditional knockout rescues cycle reentry. The E3 ligase Nedd4 mediates the ubiquitination...
Abstract DNA is a potent damage-associated molecular pattern signaling that, once in the extracellular space, triggers activation of innate immune system. Here we find that senescent cells release mtDNA to both cytosol and space. In undergoing cellular senescence, precedes nuclear resulting cGAS/STING pathway establishment senescence. Intriguingly, by exploiting co-culture vivo cross-species experiments, show released tumors specifically captured polymorphonuclear myeloid-derived suppressor...