A5087621834- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Screening and Detection
- Immune cells in cancer
- Hormonal and reproductive studies
- Circadian rhythm and melatonin
- Neuroendocrine Tumor Research Advances
- Telomeres, Telomerase, and Senescence
- MicroRNA in disease regulation
- Lung Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Lipids, and Metabolism
- Blood Coagulation and Thrombosis Mechanisms
- Prostate Cancer Treatment and Research
- Viral-associated cancers and disorders
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal disorders and treatments
AULSS 2 Marca Trevigiana
2024-2025
University of Padua
2021-2025
Istituto Oncologico Veneto
2022-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2022-2024
Veneto Institute of Molecular Medicine
2024
Accumulating senescent cells within tissues contribute to the progression of aging and age-related diseases. Botanical extracts, rich in phytoconstituents, present a useful resource for discovering therapies that could target senescence thus improve healthspan. Here, we show daily oral administration standardized extract Salvia haenkei (Haenkenium (HK)) extended lifespan healthspan naturally aged mice. HK treatment inhibited age-induced inflammation, fibrosis markers across several tissues,...
727 Background: In order to identify targetable mutations, the Comprehensive Genomic Profiling (CGP) is an important tool. Technologies like extensive genomic NGS panels analyze multiple genes and biomarkers in a single assay. With multi-omics analysis, clinicians could increase possibility provide tailored therapy. literature, evidence about clinical applicability performance of are mainly derived from trials real-world experiences lacking. Methods: On these bases, we performed...
Approximately 15 % of colorectal adenocarcinomas (CRCs) are characterized by an altered expression DNA mismatch repair (MMR) proteins (i.e. MMR deficiency [MMRd]). Lymph node ratio (LNR) represents one the most important prognostic markers in non-advanced CRCs. No significant data available regarding LNR distribution depending on status.The aim present work was to compare pathological and clinical characteristics MMRd tumors versus proficient (MMRp) cases. Particular attention paid how these...
3587 Background: The combination of BRAF inhibitors (BRAFi) plus anti-EGFR antibodies is a new standard care in V600E mutated (mut) metastatic colorectal cancer (mCRC). Nevertheless, resistance develops during the target therapy (TT). We designed URBAN study, translational prospective project, order to identify possible primary and acquired mechanisms. Methods: Patients (pts) with mut mCRC treated BRAFi + +/- MEK at Veneto Institute Oncology were enrolled. Clinical data liquid biopsy...