A5080097535- Gout, Hyperuricemia, Uric Acid
- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Osteoarthritis Treatment and Mechanisms
- Inflammasome and immune disorders
- Bone and Joint Diseases
- Therapeutic Uses of Natural Elements
- Autoimmune and Inflammatory Disorders Research
- Psoriasis: Treatment and Pathogenesis
- Musculoskeletal synovial abnormalities and treatments
- Alkaline Phosphatase Research Studies
- Tea Polyphenols and Effects
- Systemic Lupus Erythematosus Research
- Inflammatory mediators and NSAID effects
- Erythrocyte Function and Pathophysiology
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Healthcare and Venom Research
- Pharmacological Effects of Natural Compounds
- Case Reports on Hematomas
- Cytokine Signaling Pathways and Interactions
- Orthopedic Infections and Treatments
- Immune Response and Inflammation
- Myofascial pain diagnosis and treatment
- Immune Cell Function and Interaction
- Tendon Structure and Treatment
University of Padua
2015-2024
Ospedale Civile di Venezia
2024
March of Dimes
2013-2020
Institute of Geosciences and Earth Resources
2016
National Research Council
2016
Center for Rheumatology
2016
Inoue Hospital
2012
University Hospital of Geneva
2008
Accumulating senescent cells within tissues contribute to the progression of aging and age-related diseases. Botanical extracts, rich in phytoconstituents, present a useful resource for discovering therapies that could target senescence thus improve healthspan. Here, we show daily oral administration standardized extract Salvia haenkei (Haenkenium (HK)) extended lifespan healthspan naturally aged mice. HK treatment inhibited age-induced inflammation, fibrosis markers across several tissues,...
Three illustrative cases are briefly presented to demonstrate the potential fallibility in administration of a test dose prior epidural anesthesia. Possible mechanisms discussed central nervous system or cardiovascular toxic reactions local anesthetics that can occur even if demonstrates no alterations.
Gout is the most common inflammatory arthropathy of metabolic origin and it characterized by intense inflammation, underlying mechanisms which are unknown. The aim this study was to evaluate oxidative stress in human fibroblast-like synoviocytes (FLS) exposed monosodium urate (MSU) crystals, trigger an process.Human FLS isolated from synovial tissue explants were stimulated with MSU crystals (75 μg/mL) for 24 h. Cellular viability evaluated crystal violet staining, apoptosis assessed using...
Objective To assess the reliability and diagnostic accuracy of new radiographic imaging definitions developed by an international multidisciplinary working group for identification calcium pyrophosphate deposition (CPPD). Methods Patients with knee osteoarthritis scheduled replacement were enrolled. Two radiologists 2 rheumatologists twice assessed images presence or absence CPPD in menisci, hyaline cartilage, tendons, joint capsule, synovial membrane, using definitions. In case...
Abstract Imbalance in cytokine homeostasis plays an important part the pathogenesis of chronic inflammatory diseases such as multiple sclerosis and rheumatoid arthritis. We demonstrated that T cells might exert a pathological effect through direct cellular contact with human monocytes/macrophages, inducing massive up-regulation prototypical proinflammatory cytokines IL-1β TNF. This mechanism be implicated inflammation is specifically inhibited by high-density lipoproteins (HDL). Like many...
Objective To evaluate the discriminatory ability of ultrasound in calcium pyrophosphate deposition disease (CPPD), using microscopic analysis menisci and knee hyaline cartilage (HC) as reference standard. Methods Consecutive patients scheduled for replacement surgery, due to osteoarthritis (OA), were enrolled. Each patient underwent examination HC knee, scoring each site presence/absence CPPD. Ultrasound signs inflammation (effusion, synovial proliferation power Doppler) assessed...
The purpose of this study was the evaluation synovial effusion (SE), fluid (SF) and tissue (ST) biomarkers in relation to disease activity indexes assess response intraarticular (IA) tumor necrosis factor (TNF)-α blockers psoriatic arthritis (PsA).Systemic local (disease score (DAS); Ritchie articular index (mRAI), erythrocyte sedimentation rate (ESR) C-reactive protein (CRP); Thompson (THOMP) joint (KJAI)-Index ) ST samples were assessed at baseline, throughout treatment, during follow-up...
To investigate whether monosodium urate (MSU) crystals induce the production of CCL2 (monocyte chemoattractant protein-1; MCP-1) in human fibroblast-like synoviocytes (FLS) and this mechanism would be affected by high-density lipoproteins (HDL). Human FLS isolated from synovial tissue explants were stimulated with MSU (0.01 to 0.5 mg/ml) or interleukin (IL)-1β (10 pg/ml) presence absence HDL (50 100 μg/ml). The expression was evaluated ELISA, confocal microscopy, immunofluorescence...
Resveratol (RES) and its natural precursor polydatin (PD) are polyphenols that may display a broad variety of beneficial effects including anti-inflammatory properties. This study aimed to investigate the role RES PD in inflammatory process induced by monosodium urate (MSU) calcium pyrophosphate (CPP) crystals vitro. A monocytic cell line (THP-1) was primed for 3 hours with phorbol myristate acetate (100 ng/mL) stimulated synthetic MSU (0.05 mg/mL) CPP (0.025 crystals. were added cultures...
<h3>Objectives</h3> To investigate the effects and mechanisms of action high-density lipoproteins (HDL) in monosodium urate (MSU) crystal-induced inflammation —that is, gouty inflammation, vivo. <h3>Methods</h3> Air pouches raised on backs mice were injected with MSU crystals or tumour necrosis factor (TNF) presence absence HDL and/or interleukin (IL)-1 receptor antagonist (IL-1Ra) for 3 h. Leucocyte count neutrophil percentage pouch fluids measured using a haemocytometer May–Grünwald–Giemsa...
Objective: To review the evidence regarding clinical effect of spa therapy for rheumatic diseases, with particular attention given to association protocols between balneotherapy and rehabilitation interventions, support literature research studies’ selection lexical analysis. Methods: A analysis was performed considering a list words representing diseases outcome measures linked theme studied in our review. Then, two independent researchers conducted search on PubMed using string employed...