A5077051382- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Musculoskeletal synovial abnormalities and treatments
- Musculoskeletal Disorders and Rehabilitation
- Gout, Hyperuricemia, Uric Acid
- Innovations in Medical Education
- Orthopedic Surgery and Rehabilitation
- Shoulder Injury and Treatment
- Tendon Structure and Treatment
- Catalytic Alkyne Reactions
- Osteoarthritis Treatment and Mechanisms
- Elbow and Forearm Trauma Treatment
- Inflammasome and immune disorders
- Hip disorders and treatments
- Salivary Gland Disorders and Functions
- Case Reports on Hematomas
- Cyclopropane Reaction Mechanisms
- Catalysis and Hydrodesulfurization Studies
- Crystallization and Solubility Studies
- Clinical Reasoning and Diagnostic Skills
- Systemic Sclerosis and Related Diseases
- Spondyloarthritis Studies and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Lymphadenopathy Diagnosis and Analysis
- X-ray Diffraction in Crystallography
Instituto Nacional de Rehabilitación
2015-2024
Hospital Juárez de México
2023-2024
Emory University
2023
American College of Rheumatology
2023
Durham VA Medical Center
2023
University of North Carolina at Chapel Hill
2023
El Colegio de México
2017
Universidad de Oviedo
2012-2016
Secretaria de Salud
2015
Hôpital Notre-Dame
2010
In this study, we aimed to investigate ultrasonographic (US) changes suggestive of gouty arthritis in the hyaline cartilage, joints and tendons from asymptomatic individuals with hyperuricemia.We conducted a cross-sectional, controlled study including US examinations knees first metatarsal-phalangeal (first MTPJs), as well enthesis lower limbs. Differences were estimated by χ² or unpaired t-tests appropriate. Associations calculated using Spearman's correlation coefficient rank test.Fifty...
To develop ultrasound (US) definitions and a US novel scoring system for major salivary gland (SG) lesions in patients with primary Sjögren's syndrome (pSS) to test their intrareader inter-reader reliability using video clips.Twenty-five rheumatologists were subjected three-round, web-based Delphi process order agree on (1) scanning procedure of ultrasonography (SGUS): parotid, submandibular sublingual glands (PG, SMG SLG); (2) the elementary SGUS syndrome; (3) grading changes. The experts...
Golden touch: N-allenylsulfonamides react with styrene derivatives to furnish chiral cyclobutanes in both high yield and enantioselectivity at −70 °C. Phosphoramidite ligands such as 1, facilitate this asymmetric gold(I)-catalyzed [2+2] cycloaddition. Tf=trifluoromethanesulfonyl.
To assess, in spondyloarthritis (SpA), the discriminative value of Outcome Measures Rheumatology (OMERACT) ultrasound lesions enthesitis and their associations with clinical features this population.
Abstract Addition of catalytic amounts a phosphite‐based gold(I) catalyst efficiently triggers the intermolecular [2+2] cycloaddition allenes and alkenes substituted by electron‐donor groups. The reaction is fast furnishes cyclobutane derivatives in stereoselective manner using low loadings. Besides, same selectively affords homodimerization products from starting allene, process that may be conveniently fine tuned addition norbornene.
Gout is the most common inflammatory arthropathy of metabolic origin and it characterized by intense inflammation, underlying mechanisms which are unknown. The aim this study was to evaluate oxidative stress in human fibroblast-like synoviocytes (FLS) exposed monosodium urate (MSU) crystals, trigger an process.Human FLS isolated from synovial tissue explants were stimulated with MSU crystals (75 μg/mL) for 24 h. Cellular viability evaluated crystal violet staining, apoptosis assessed using...
Objective To determine the intra‐ and interobserver reliability of ultrasound ( US )‐detected age‐related joint vascularization ossification grading in healthy children. Methods Following standardized image acquisition machine setting protocols, 10 international experts examined 4 joints (wrist, second metacarpophalangeal joint, knee, ankle) 12 children (divided into age groups: 2–4, 5–8, 9–12, 13–16 years). Gray‐scale was used to detect grade, power Doppler PDUS ) physiologic...
Recently preliminary ultrasonography (US) definitions, in B mode, for normal components of pediatric joints have been developed by the OMERACT US group. The aim current study was to include Doppler findings evaluation and definition joint features that can be visualized healthy children at different age groups. A multistep approach used. Firstly, new additional definitions were proposed during an expert meeting. In second step, these along with B-mode-US tested feasibility exercise last a...
To assess potential associations among serum cytokines and microRNA (miR) levels with ultrasound (US) findings suggestive of urate deposits in chronic asymptomatic hyperuricemia gout.All participants underwent musculoskeletal US measurements interleukin-1β (IL-1β), IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, interferon-γ, tumor necrosis factor, monocyte chemoattractant protein 1, epithelial neutrophil-activating peptide 78, as well miR-146a, miR-155, miR-223 levels.Thirty individuals...
Ein Hauch von Gold: N-Allenylsulfonamide reagieren bei −70 °C mit Styrolderivaten in hohen Ausbeuten und Enantioselektivitäten zu chiralen Cyclobutanen. Phosphoramidit-Liganden wie 1 vermitteln diese asymmetrische Gold(I)-katalysierte [2+2]-Cycloaddition. Tf=Trifluormethansulfonyl.
Musculoskeletal Ultrasonography (MSUS) is an important tool for the clinical assessment in Juvenile Idiopathic Arthritis (JIA). The objective of this study was to evaluate reliability MSUS detect elementary lesions: synovitis, tenosynovitis, cartilage damage and bone erosions wrist metacarpal (MCP) joints patients with JIA.Thirty children various subgroups JIA according ILAR criteria, were included cross-sectional study. Clinical data including painful, swollen limited recorded. Five...
The aim of this exercise from the OMERACT Ultrasound subgroup on Sjögren's syndrome was to develop and assess reliability a consensus-based semiquantitative colour Doppler US scoring system for pathologic salivary gland vascularization in patients with primary (pSS).Using Delphi method, bilateral parotid submandibular glands developed tested static images (9 pSS 9 sonographers). Intra-reader inter-reader grading were computed by weighted Cohen Light's kappa analysis, respectively.The score...
To assess the intra- and interobserver reproducibility of musculoskeletal ultrasonography (US) in detecting inflammatory shoulder changes patients with rheumatoid arthritis, to determine agreement between US Shoulder Pain Disability Index (SPADI) Disabilities Arm, Shoulder, Hand (DASH) questionnaire, using magnetic resonance imaging (MRI) as a gold standard.Eleven rheumatologists investigated 10 2 rounds independently blindly each other by US. results were compared function tests MRI.The...
Objective To describe the prevalence of sternoclavicular (SC) joint involvement and relationship between clinical ultrasound (US) findings in patients with rheumatoid arthritis (RA). Methods One hundred three consecutive RA 103 age‐ sex‐matched healthy individuals were enrolled. Clinical evaluation blinded US examinations SC performed bilaterally both groups. The presence gray‐scale synovitis, osteophytes, erosions, intraarticular power Doppler (PD) was recorded. Interobserver agreement...
To investigate the reliability of OMERACT US Task Force definition enthesitis in SpA.In this web exercise, based on evaluation 101 images and 39 clips main entheses lower limbs, elementary components included SpA (hypoechoic areas, entheseal thickening, power Doppler signal at enthesis, enthesophytes/calcifications, bone erosions) were assessed by 47 rheumatologists from 37 rheumatology centres 15 countries. Inter- intra-observer was calculated using Light's kappa, Cohen's Prevalence And...
There is growing evidence that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to dysregulation of the immune system and, consequently, development autoimmune phenomena. Here, we describe case a 75-year-old woman rheumatic manifestations characterized by intense musculoskeletal pain and stiffness in neck shoulders, sudden onset inability raise her arms. The patient was admitted located shoulders. Previously, she had oropharyngeal pain, fatigue, fever;...
Objectives To investigate the inter/intra-reliability of ultrasound (US) muscle echogenicity in patients with rheumatic diseases. Methods Forty-two rheumatologists and 2 radiologists from 13 countries were asked to assess US quadriceps 80 static images 20 clips 64 different diseases 8 healthy subjects. Two visual scales evaluated, a semi-quantitative scale (0–3) continuous quantitative measurement (“VAS echogenicity,” 0–100). The same assessment was repeated calculate intra-observer...
To develop guidelines for Musculoskeletal Ultrasound (MSKUS) training rheumatologists in the Americas.A total of 25 Rheumatologists from 19 countries American Continent participated a consensus-based interactive process (Delphi method) using 2 consecutive electronic questionnaires. The first questionnaire included following: relevance organizing courses to teach MSKUS Rheumatologists, determination most effective educational course models, trainee levels, objectives, requirements passing...
Osteoarthritis (OA) is a multifactorial degenerative condition of the whole joint with complex pathogenesis whose development and progression significantly mediated by interactions between cartilage articular tissues, particularly, proinflammatory mediators oxidative stress, which results in deterioration subchondral bone destruction. HIF-1 alpha regulates oxygen homeostasis hypoxic tissues such as cartilage; efficiency transcriptional activity HIF1A gene strongly influenced presence...
Currently, two pathogenic pathways describe the role of obesity in osteoarthritis (OA); one through biomechanical stress, and other by contribution systemic inflammation. The aim this study was to evaluate effect free fatty acids (FFA) human chondrocytes (HC) expression proinflammatory factors reactive oxygen species (ROS). HC were exposed different concentrations FFA order secretion adipokines cytokines immunoassays panel, quantify protein FFA-treated chondrocytes, fluorescent cytometry...