A5000885316- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Biosimilars and Bioanalytical Methods
- Chronic Lymphocytic Leukemia Research
- Psoriasis: Treatment and Pathogenesis
- Renal Diseases and Glomerulopathies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Urticaria and Related Conditions
- Sarcoidosis and Beryllium Toxicity Research
- Atherosclerosis and Cardiovascular Diseases
- Eosinophilic Disorders and Syndromes
- Inflammasome and immune disorders
- Bone and Joint Diseases
- Gout, Hyperuricemia, Uric Acid
- Monoclonal and Polyclonal Antibodies Research
- Spinal Hematomas and Complications
- Systemic Sclerosis and Related Diseases
- Shoulder Injury and Treatment
- Microscopic Colitis
- Lipoproteins and Cardiovascular Health
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Otitis Media and Relapsing Polychondritis
Hacettepe University
2020-2024
Ege University
2015-2024
Hippocration General Hospital
2023
Ankara University
2023
Tokyo Metropolitan Tama Medical Center
2023
Center for Rheumatology
2021-2023
National and Kapodistrian University of Athens
2023
University of Pennsylvania
2022
Cancer Research And Biostatistics
2022
Turkish Thoracic Society
2022
To assess, in spondyloarthritis (SpA), the discriminative value of Outcome Measures Rheumatology (OMERACT) ultrasound lesions enthesitis and their associations with clinical features this population.
To investigate the reliability of OMERACT US Task Force definition enthesitis in SpA.In this web exercise, based on evaluation 101 images and 39 clips main entheses lower limbs, elementary components included SpA (hypoechoic areas, entheseal thickening, power Doppler signal at enthesis, enthesophytes/calcifications, bone erosions) were assessed by 47 rheumatologists from 37 rheumatology centres 15 countries. Inter- intra-observer was calculated using Light's kappa, Cohen's Prevalence And...
The study objectives were (i) to explore the agreement between Outcome Measures in Rheumatology (OMERACT) ultrasound lesions of enthesitis and physical examination assessing patients with spondyloarthritis (SpA) (ii) investigate prevalence clinical relevance subclinical this population.
Background/aim: To assess the real-life efficacy, retention rate, and safety data of tofacitinib in rheumatoid arthritis (RA) patients. Materials methods: We analyzed all patients registered HURBİO database who received at least 1 dose tofacitinib. Patients one were included analysis; with control visit efficacy analysis. Factors predicting good response last follow-up by logistic regression Drug rates calculated using Kaplan-Meier method predictors drug determined Cox proportional hazard...
The development of serologic tests for antineutrophil cytoplasmic antibodies (ANCA) has enabled a better characterization the small vessel vasculitides that include Wegener’s granulomatosis, Churg–Strauss syndrome, and microscopic polyangiitis.1 ANCA-associated can involve central peripheral nervous systems.2 This report summarizes case patient who sought treatment ischemic optic neuropathy, an unusual complication these disorders. A 67-year-old man was referred evaluation partial loss...
We aimed to compare clinical features, outcomes, treatments, and define the predictive factors of complete renal response (CRR) in patients with proliferative non-proliferative lupus nephritis (LN).Patients systemic erythematosus (SLE) followed between 2014 2020 at Hacettepe University Hospitals who had a kidney biopsy were subject study. One hundered sixteen patients' biopsies reported as LN evaluated retrospectively. Clinical characteristics laboratory values time biopsy, histopathological...
The objectives of this study were to assess the clinical characteristics, predictive factors, and practical algorithms paradoxical reactions (PRs), specifically psoriasis (PP).
Background/aim: Gout may cause various radiographic abnormalities such as cartilage loss, spurs, sclerosis, and periostal new bone formation. The purpose of this study was to investigate the frequency Achilles plantar spurs related factors in gout patients. Matherial methods: We performed a retrospective review patients, treated at Hacettepe University hospitals between 2014 2019. identified patients from hospital records using ICD-10 code (M10). Demographic clinical features, comorbidities,...
Background Tofacitinib is a targeted synthetic DMARD that selectively inhibits Janus kinase (JAK) and approved for the treatment of RA by FDA in 2012. In recent years, an important safety concern related to incidence adverse events after with tofacitinib has emerged. Objectives To evaluate risk major cardiovascular (MACE), venous thromboembolism (pulmonary embolism or deep vein thrombosis), serious infections requiring hospitalization, herpes zoster patients aged ≥ 60 years. Methods HUR-BIO...
Abstract Background Approximately 80% of all proximal humeral fractures (PHFs) are non-displaced or minimally displaced fractures, which can be treated with conservative treatment. This study investigated the effect interferential current (IFC) added to orthopedic rehabilitation on shoulder function, pain, and disability in patients PHF. Methods was a prospective, double-blind, randomized, placebo-controlled conducted physical medicine outpatient clinic. Thirty-five were randomly separated...
<h3>Background:</h3> ANCA-associated vasculitis (AAV) is a systemic disorder primarily affecting small blood vessels. While its classic manifestations involve the respiratory and renal systems, central nervous system (CNS) involvement increasingly recognized. The diverse CNS can be as ischemic or hemorrhagic events, parenchymal inflammatory lesions, pachymeningitis, cranial involvement, hypophysitis. <h3>Objectives:</h3> To highlight analyze incidence disease characteristics of patients with...
Biosimilars offer cost-effective and safe treatment options both for patients healthcare systems. CT-P10 is the first biosimilar of rituximab approved in Europe use all indications originator (oRTX). This study aimed to provide real-life data on changes adverse events who received oRTX or CT-P10. We retrospectively reviewed treatment-related [infusion-related reactions (IRRs), infections, hypogammaglobulinemia] treated with at least one dose (MabThera®) (Truxima®) between 2020 2021 had 6...
This study aimed to assess the incidence of hematologic malignancy (HM) among inflammatory arthritis (IA) patients receiving tumor necrosis factor inhibitors (TNFi) compared with general Turkish population.HUR-BIO (Hacettepe University Rheumatology Biologic Registry) is a single-center biological disease-modifying anti-rheumatic drug (bDMARD) registry since 2005. Patients IA, including rheumatoid arthritis, spondyloarthritis, or psoriatic who had at least one visit after TNFi were screened...
Background: Tofacitinib (TOF) is an orally administered Janus Kinase (JAK) inhibitor and commonly used in rheumatoid arthritis. There a heterogeneity among numbers reported from different continents about herpes zoster (HZ) incidence rate (1-3). However, data HZ risk our country, which stands like bridge between Asia Europe, lacking. Objectives: To assess the real-life of RA patients under tofacitinib. Methods: We analyzed all who had at least 1 control visit tofacitinib registered to HURBIO...
Background: Obesity could be a risk factor for response to treatment and disease severity in psoriatic arthritis (PsA) because of potential pro-inflammatory effects cytokines produced by adipose tissue (1). Objectives: This study aimed assess association demographic, clinical activity indices with obesity patients using biological disease-modifying antirheumatic drugs (bDMARD) HUR-BIO cohort. Methods: (Hacettepe University Rheumatology Biologic Registry) is prospective, single center...
Background: Biologic disease modifying anti-rheumatic drugs (bDMARD) are revolutionary treatment options for management of inflammatory arthritis. Secukinumab (SEC), anti-interleukin-17A monoclonal antibody, is a new alternative choice to anti-TNFs and IL-12/23 blocking agents in the therapy psoriatic arthritis (PsA). In Turkey, government health insurance system covers secukinumab at bDMARD-refractory PsA patients. Objectives: this study, analyzing parameters that related with effectiveness...
Background: Conventional synthetic disease modifiying anti-rheumatic drugs (csDMARDs) are recommended as the first-line treatment options for most of psoriatic arthritis (PsA) patients. In last two decades, biologic become more accessible and their percentage in daily practice is increasing continuously. However, how they influenced utilization csDMARDs still remains unknown, yet. Objectives: To determine rates PsA patients before, after at starting DMARDs Methods: We analyzed all who...
Abstract Objectives Thrombotic events are common in systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). Warfarin is the most commonly used anticoagulant drug for thrombosis treatment, but it can interact with many drugs, foods, or medicinal herbs. Herein, we presented a case SLE APS who was complicated by spinal cerebral hematoma as result of warfarin interaction. Case presentation Spinal subdural frontal intraparenchymal were occurred our patient, remission 2 years...