A5018403925- Osteoarthritis Treatment and Mechanisms
- Therapeutic Uses of Natural Elements
- Inflammatory mediators and NSAID effects
- Rheumatoid Arthritis Research and Therapies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Myofascial pain diagnosis and treatment
- Systemic Sclerosis and Related Diseases
- Systemic Lupus Erythematosus Research
- Tendon Structure and Treatment
- Congenital Heart Disease Studies
- Autoimmune and Inflammatory Disorders Research
- Adipokines, Inflammation, and Metabolic Diseases
- Musculoskeletal pain and rehabilitation
- Orthopedic Surgery and Rehabilitation
- Complementary and Alternative Medicine Studies
- Blood disorders and treatments
- Immunodeficiency and Autoimmune Disorders
- Proteoglycans and glycosaminoglycans research
- Colorectal Cancer Treatments and Studies
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Medical and Biological Ozone Research
- Platelet Disorders and Treatments
- Osteomyelitis and Bone Disorders Research
- Inflammatory Myopathies and Dermatomyositis
University of Siena
2014-2025
Azienda Ospedaliera Universitaria Senese
2016-2024
Center for Rheumatology
2023
Università Campus Bio-Medico
2019
Ospedale Santa Maria alle Scotte
2010-2019
Sbarro Health Research Organization
2019
Temple University
2019
Istituti di Ricovero e Cura a Carattere Scientifico
2015
Institute of Neurological Sciences
2015
University of Bologna
2015
In our modern era, stress has become a pervasive challenge, affecting individuals across all ages and backgrounds. Acute or chronic elevated cortisol levels are known to impair neurological function hinder rehabilitation outcomes. Therefore, effective treatment methods that reduce stress, enhance mental health, promote overall well-being urgently needed. The aim of this study was evaluate the seasonal impact balneotherapy on distress, as measured by General Symptoms Distress Scale (GSDS),...
Fioravanti A, Iacoponi F, Bellisai B, Cantarini L, Galeazzi M: Short- and long-term effects of spa therapy in knee osteoarthritis. Objective: To assess both the short- effectiveness patients with primary osteoarthritis a prospective, randomized, single-blinded, controlled trial. Design: Eighty outpatients were enrolled this study; 40 treated combination daily local mud packs bicarbonate-sulfate mineral bath water from center Rapolano Terme (Siena, Italy) for 2 wks, continued regular, routine...
Mechanical loading and hydrostatic pressure (HP) regulate chondrocytes' metabolism; however, how mechanical stimulation acts remain unclear. MicroRNAs (miRNAs) play an important role in cartilage homeostasis, mechanotransduction, the pathogenesis of osteoarthritis (OA). This study investigated effects a cyclic HP (1-5 MPa), both normal OA human chondrocytes, on expression miR-27a/b, miR-140, miR-146a/b, miR-365, their target genes (MMP-13, ADAMTS-5, IGFBP-5, HDAC-4). Furthermore, we assessed...
Current evidence suggests a complex interaction between adipokines and microRNA (miRNA) in osteoarthritis (OA) pathogenesis. The present study explored the role of miR-34a miR-181a regulating apoptosis oxidative stress induced by visfatin human OA chondrocytes. Chondrocytes were transfected with inhibitors stimulated for 24 h, presence nuclear factor (NF)-κB inhibitor (BAY-11-7082, 2 h pre-incubation). Apoptosis reactive oxygen species (ROS) production detected cytometry, miRNA, antioxidant...
To establish by ultrasonography (US) the frequency of calcaneal entheses involvement in erosive osteoarthritis (EOA), nodal (NOA), RA and PsA, to compare these results order aid clinicians differential diagnosis among diseases. A comparison between US radiography was also made.The heels 56 consecutive outpatients with EOA, 209 NOA, 158 125 PsA were studied radiography. control group 50 subjects examined US.US showed no significant difference inferior enthesophytosis four The posterioinferior...
Abstract Purpose: GOLFIG chemoimmunotherapy regimen proved to be a safe and very active in advanced colon cancer patients. We have thus investigated the immunobiological feedback treatment its possible correlation with clinical outcome of these Experimental Design: This immunologic study involved 46 patients, 27 males 19 females, enrolled GOLFIG-1 phase II trial who received gemcitabine (1,000 mg/m2 on days 1 15), oxaliplatin (85 2 16), levofolinic acid (100 1, 2, 15, 5-fluorouracil (400 as...
Oxidative stress and the overproduction of reactive oxygen species (ROS) play an important role in pathogenesis osteoarthritis (OA). Accumulating evidence has demonstrated involvement microRNAs (miRNAs) dysregulation disease development progression. In this study, we evaluated effect oxidative on miR-146a miR-34a expression levels human OA chondrocytes cultures stimulated by H2O2. Mitochondrial ROS production cell apoptosis were detected flow cytometry. The antioxidant enzymes SOD-2, CAT,...