A5039189863- Orthopaedic implants and arthroplasty
- Hip and Femur Fractures
- Osteoarthritis Treatment and Mechanisms
- Hip disorders and treatments
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Pelvic and Acetabular Injuries
- Gout, Hyperuricemia, Uric Acid
- Trauma Management and Diagnosis
- Shoulder Injury and Treatment
- Bone fractures and treatments
- Bone and Joint Diseases
- Trauma and Emergency Care Studies
- Bone Tissue Engineering Materials
- Hidradenitis Suppurativa and Treatments
- Periodontal Regeneration and Treatments
- Shoulder and Clavicle Injuries
- Autoimmune and Inflammatory Disorders
- Spine and Intervertebral Disc Pathology
- Infectious Diseases and Tuberculosis
- Venous Thromboembolism Diagnosis and Management
- Inflammatory mediators and NSAID effects
- Sports injuries and prevention
- Spinal Fractures and Fixation Techniques
- Intracerebral and Subarachnoid Hemorrhage Research
University of Siena
2009-2023
Ospedale Santa Maria alle Scotte
2014-2018
University of Verona
1982
University of Padua
1982
Mechanical loading and hydrostatic pressure (HP) regulate chondrocytes' metabolism; however, how mechanical stimulation acts remain unclear. MicroRNAs (miRNAs) play an important role in cartilage homeostasis, mechanotransduction, the pathogenesis of osteoarthritis (OA). This study investigated effects a cyclic HP (1-5 MPa), both normal OA human chondrocytes, on expression miR-27a/b, miR-140, miR-146a/b, miR-365, their target genes (MMP-13, ADAMTS-5, IGFBP-5, HDAC-4). Furthermore, we assessed...
Abstract The application of porous hydroxyapatite (HAp)‐collagen as a bone tissue engineering scaffold represents new trend mimicking the specific extracellular matrix (ECM). use HAp in reconstructive surgery has shown that it is slowly invaded by host tissue. Therefore, implant compatibility may be augmented seeding cells before implantation. Human primary osteoblasts were seeded onto innovative collagen‐gelatin‐genipin (GP)‐HAp scaffolds containing respectively 10%, 20%, and 30% HAp....
Background . The sensitivity and the specificity of different methods to detect periprosthetic infection have been questioned. current study aimed investigate kinetics C-reactive protein (CRP) procalcitonin (PCT) in patients undergoing uncomplicated elective total hip arthroplasty (THA), provide a better interpretation their levels noninfectious inflammatory reaction. Methods A 51 were included. Serum CRP PCT concentrations obtained before surgery, on 1st, 3rd, 7th postoperative days after...
Purpose This study aims to analyze the risk factors and type of injuries occurring in Taekwondo athletes participating a national competition. Methods Out 127 competitors, 18 got injured during championship who were analyzed for following parameters: modality training; age, weight; belt color; injury. Results Around 89% due bruising found mainly on lower limbs (61%) elimination rounds first match day. The higher probability injury was second round (56%), day (72%). Nearly all able complete...
Osteoarthritis (OA) is the most frequent joint disease, characterized by degradation of extracellular matrix and alterations in chondrocyte metabolism. Some authors reported that electromagnetic fields (EMFs) can positively interfere with patients affected OA, even though nature interaction still debated. Human primary osteoarthritic chondrocytes isolated from femoral heads OA-patients undergoing to total hip replacement, were cultured vitro exposed 30 min/day for two weeks...
Vulvodynia is defined as a chronic vulvar pain non-associated with infectious, inflammatory, neoplastic or hormonal disorders.To present case demonstrating the difficulty in assessing concomitant disease vulvodynia.A 26-year-old woman, presented persistent vulvodynia. She received oral and topical medications behavioural interventions to lessen sexual restore sexuality. As decreased, patient reported symptoms previously not mentioned: continuous, intense periclitoral numbness at perineum...
To investigate if a locking intramedullary nail could be useful in the treatment of fractures humeral head 3 and 4-fragments operated within 48 h from trauma. During period February 2011–May 2013, we performed 21 cases treated with Polarus (Acumed). We considered parameters such as age, sex, time radiological healing functional outcome, which were assessed by Constant shoulder score, University California at Los Angeles Oxford score Dash score. The study was designed prospective cohort...
Introduction . The periprosthetic fracture of the femur is, in order frequency, fourth leading cause (5.9%) surgical revision. Our study aims to demonstrate how grafting bone splint betters outcomes. Materials We treated 15 femoral fractures divided into two groups: PS composed 8 patients with plates and splints PSS involving 7 only plates. evaluation criteria for groups during clinical radiological follow-up were quality life measured by Short Form (36) Health Survey (SF-36), Harris Hip...
Intra-articular (i.a.) hyaluronic acid is an accepted conservative therapy for knee osteoarthritis (OA). This study evaluated the safety and efficacy of a single i.a. injection innovative formulation sodium hyaluronate 2.4% plus chondroitin non-sulphated 1.6% biotechnological origin (HA-SC) treatment patients with radiographically confirmed symptomatic hip OA moderate-to-severe pain. In this prospective, multicenter, open-label, pilot study, HA-SC was administered using standard...
Neck and back pain afflicts millions of people. Magnetotherapy has shown to have anti-inflammatory effects that could act on generation, but the literature lacks provide a precise therapeutic protocol.A high-intensity electromagnetic field with dedicated applicator was administered 38 patients low-back 30 neck pain. The device provides 60 mT frequency 50 Hz for minutes, session repeated 4 times.The mean VAS group decreased from 6.56 4.54, significant reduction 30.8%. 6.51 1.96, 69.9%.The...
To report our experience of regional referral center for the pelvis. We treated 526 pelvic fractures from January 2004 to December 2014 in three reference centers trauma. Men were 480 and women 46 ages ranged 16 93 years old. Car (65%) farm (20%) crashes most frequent causes pelvis fractures. Injury severity scores 9.0 75.0, with a mean 37.5. A defined algorithm fracture management has been place employed assure adequate resuscitation care. There 24 deaths total (4.56%). Sixty (11.98%)...
"Histology of the synovial membrane patients affected by osteoarthritis and calcium pyrophosphate dihydrate crystal deposition disease vs. alone: a pilot study." Scandinavian Journal Rheumatology, 45(6), pp. 538–539
This study investigated the role of a pattern microRNA (miRNA) as possible mediators celecoxib and prescription-grade glucosamine sulfate (GS) effects in human osteoarthritis (OA) chondrocytes. 
 Chondrocytes were treated with (1.85 µM) GS (9 µM), alone or combination, for 24 hrs, without interleukin (IL)-1β (10 ng/mL). Viability was detected by MTT assay, apoptosis reactive oxygen species (ROS) cytometry, nitric oxide (NO) Griess method. Gene levels miRNA, antioxidant enzymes, nuclear...