A5047281058- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Chemokine receptors and signaling
- Glycosylation and Glycoproteins Research
- Immunotherapy and Immune Responses
- Protein Tyrosine Phosphatases
- Immune Cell Function and Interaction
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Cell Adhesion Molecules Research
- CAR-T cell therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- RNA modifications and cancer
- Galectins and Cancer Biology
- Gene Regulatory Network Analysis
- T-cell and B-cell Immunology
- Hemoglobinopathies and Related Disorders
- Single-cell and spatial transcriptomics
- Immunodeficiency and Autoimmune Disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Adenosine and Purinergic Signaling
- Chronic Lymphocytic Leukemia Research
- HER2/EGFR in Cancer Research
- Pancreatic function and diabetes
- Botulinum Toxin and Related Neurological Disorders
Institute of Oncology Research
2018-2023
University of Verona
2015-2017
// Alessio Montresor 1, 2 , Lara Toffali Michela Mirenda 1 Antonella Rigo 3 Fabrizio Vinante Carlo Laudanna Department of Pathology and Diagnostics, Division General Pathology, Laboratory Cell Trafficking Signal Transduction, University Verona, Verona 37134, Italy, EU The Center for Biomedical Computing (CBMC), Medicine, Section Hematology, Cancer Research & Biology Laboratory, Correspondence to: Laudanna, e-mail: carlo.laudanna@univr.it Keywords: chronic lymphocytic leukemia, adhesion,...
Abstract The CD47-SIRPα axis is a critical checkpoint that prevents SIRPα-positive macrophages from phagocytosing CD47-expressing solid tumors. Several agents aiming to block this have recently entered early clinical trials including anti-CD47 and anti-SIRPα monoclonal antibodies (mAb). These inhibitors (CPI) aim modulate the phagocytotic activity of endogenous tumor associated (TAMs). However, adoptive transfer resistant CD47-based inhibition in microenvironment (TME) could also increase...
Abstract Regulation of signal transduction networks depends on protein kinase and phosphatase activities. Protein tyrosine kinases the JAK family have been shown to regulate integrin affinity modulation by chemokines mediated homing secondary lymphoid organs human T lymphocytes. However, role phosphatases in leukocyte recruitment is still elusive. In this study, we address issue focusing receptor type γ (PTPRG), a highly expressed primary monocytes. We developed novel methodology study...
Abstract JAK-dependent activation of the rho module integrin affinity triggering mediates chemokine-induced leukocyte adhesion. However, signaling events linking JAKs to small GTPase by chemokines is still incompletely described. In this study, we show that son sevenless 1 (SOS1), guanine nucleotide exchange factor (GEF)1 (ARHGEF1), and dedicator cytokinesis (DOCK)2 GEFs mediate CXCL12-induced LFA-1 in human primary T lymphocytes. Downregulated expression SOS1, ARHGEF1, DOCK2 impairs...
Infrared microspectroscopy complemented with unsupervised principal component analysis is a suitable method to study protein phosphorylation/de-phosphorylation balance in cell models.
Abstract Chimeric antigen receptor (CAR) based T-cell immunotherapies have transformed the oncology landscape and evolved as part of standard care for several hematological malignancies. To generate CAR-T-cell products, autologous patient-derived αβT-cells are engineered with a CAR tumor cell targeting. However, generating products fails in significant number cases due to poor quality quantity blood-derived T-cells is associated manufacturing logistical complexity well high product costs....
Boolean models are gaining an increasing interest for reproducing dynamic behaviours, understanding processes, and predicting emerging properties of cellular signalling networks through in-silico experiments. They as a valid alternative to the quantitative approaches (i.e., based on ordinary differential equations) exploratory modelling when little is known about reaction kinetics or equilibrium constants in context gene expression signalling. Even though several software have been recently...
Calcium dobesilate (calcium 2,5-dihydroxybenzenesulfonate, CaD) is an oral drug currently used for the treatment of chronic venous insufficiency and microangiopathies such as diabetic retinopathy. Treatment with CaD prevents reactive gliosis neuronal loss in animal models Furthermore, reduces oxygen species production by neutrophils vitro lowers pro-inflammatory cytokines disease models. However, its effect on neuroinflammation Alzheimer's (AD) unknown our goal was to determine potential...
Abstract Current autologous cell therapies, with blockbuster products on the market, have been leading for a decade to unprecedented clinical successes in patients hematological malignancies. However, these patient-derived T-cell therapies are facing many challenges. The use of GMP iPSC lines produce immune effector cells will reduce complexity manufacturing process and provide an unlimited source starting material. goal EVOcells Oncology platform is offer truly allogeneic therapy treat...
<h3>Background</h3> One avenue of recent research has focused on harnessing the patient's immune system to eradicate tumors called immunotherapies. To do so, T cells from a cancer patient are harvested and genetically modified express chimeric antigen receptor (CAR), capable recognizing tumor cells, then reinfused into patient. CARs synthetic transmembrane proteins composed tumor-targeting domain, membrane anchoring domain complex signaling activate promoting cell killing. These therapies...
<h3>Background</h3> Cellular immunotherapy has transformed the oncology landscape and provided promising treatment options for patients suffering from hematological malignancies in form of chimeric antigen receptor (CAR)-T therapies, which involve adoptive transfer autologous patient-derived ab T cells equipped with a CAR enhanced tumor cell targeting. However, manufacturing complexity logistical hurdles associated such products have shifted focus to development allogenic therapies including...