A5046933867- HIV Research and Treatment
- Autoimmune and Inflammatory Disorders Research
- Cancer, Lipids, and Metabolism
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Cellular transport and secretion
- HIV, Drug Use, Sexual Risk
- Metabolomics and Mass Spectrometry Studies
- Cytomegalovirus and herpesvirus research
- HIV-related health complications and treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Hepatitis B Virus Studies
- Inflammasome and immune disorders
- Cancer Immunotherapy and Biomarkers
- HIV/AIDS oral health manifestations
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Research and Treatments
- Systemic Lupus Erythematosus Research
- Legal and Labor Studies
- Pulmonary Hypertension Research and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
IRCCS Humanitas Research Hospital
2021-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2020
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2020
Vita-Salute San Raffaele University
2020
SAIC-GM (China)
2020
Humanitas University
2020
University of Milan
2016-2018
Luigi Sacco Hospital
2016-2018
University of Bologna
2014
Dulbecco Telethon Institute
2014
Tumor-associated macrophages (TAMs) are correlated with the progression of prostatic adenocarcinoma (PCa). The mechanistic basis this correlation and therapeutic strategies to target TAMs in PCa remain poorly defined. Here, single-cell RNA sequencing was used profile transcriptional landscape human PCa, leading identification a subset characterized by dysregulation pathways associated lipid metabolism. This correlates positively shorter disease-free survival is an accumulation lipids that...
Inflammasome-mediated activation of caspase-1 regulates inflammatory responses and pyroptosis. We analyzed possible associations between inflammasome-related genes immune reconstitution in HIV-infected antiretroviral therapy (ART)-treated patients.Cross-sectional, case-control study. patients on ART for ≥24 months with HIV-RNA<50 cp/mL ≥12 were enrolled defined as immunological responders (IR) or non-responders (INR) if CD4 count was ≥500 ≤350 cells/μL, respectively. Expression inflammasome...
Abstract Nitazoxanide (Alinia ® , NTZ) and tizoxanide (TIZ), its active circulating metabolite, belong to a class of agents known as thiazolides (TZD) endowed with broad anti-infective activities. TIZ RM-4848, the metabolite RM-5038, were shown stimulate innate immunity in vitro . Because natural resistance HIV-1 infection HIV-exposed seronegative (HESN) individuals is suggested be associated strong immune responses, we verified whether RM-4848 could reduce infectiousness HIV-1. Peripheral...
Interleukin-21 (IL-21) modulates HIV-1 infection through the elicitation of different antiviral mechanisms, including Th17 lineage commitment and induction microRNA (miR)-29, a miRNA endowed with anti-HIV activity. As miR-29 expression is significantly increased in HIV-1-exposed seronegative individuals (HESN), we investigated role miR-29/IL21 axis natural control infection.Peripheral blood mononuclear cells (PBMCs) isolated from 15 Italian sexually exposed HESN HIV-unexposed healthy...
Abstract The Δ32-CCR5 deletion of the CCR5 receptor is protective toward coronary artery pathology and myocardial infarction. Maraviroc (MVC), a antagonist, was recently introduced in therapy HIV infection; we evaluated whether this drug could modulate atherosclerotic burden aviremic PI-treated HIV-positive individuals who underwent MVC intensification. Thus, effect on intima media thickness, arterial stiffness, metabolic parameters, pro-inflammatory cytokines, endothelial dysfunction,...
GDI1 gene encodes for αGDI, a protein controlling the cycling of small GTPases, reputed to orchestrate vesicle trafficking. Mutations in human are responsible intellectual disability (ID). In mice with ablated Gdi1, model ID, impaired working and associative short-term memory was recorded. This cognitive phenotype worsens if deletion αGDI expression is restricted neurons. However, whether astrocytes, key homeostasis providing neuroglial cells, supporting neurons via aerobic glycolysis,...
HBV vaccine induces protective antibodies only in 23-56% of HIV-infected children. The aim our study is to evaluate the immunologic effects a booster dose youth.53 young patients whom vaccination did not elicit Ab titers were enrolled. All on ART with optimal immunological and viral response.All received (HBVAXPRO 10 μg i.m.). HBV-specific titer, load CD4+ T cells measured at baseline (T0), T1, T6 T12 months. In subgroup 16 cell mediated immune responses evaluated baseline, T1 T6.The induced...
To evaluate changes in pro-atherosclerotic biomarkers and endothelial function patients initiating two different PI-based regimens as part of ART.Prospective randomized 24 week study. Treatment-naive HIV-infected with CD4+ T cell count >250 cells/mm3 started including atazanavir/ritonavir (Group A) or lopinavir/ritonavir B) were followed up an observational follow-up study until 96.The expression immune activation adhesion molecules on CD8+ cells plasma cytokine levels assessed at weeks 0,...
Background: Cytomegalovirus (CMV) infection has been associated with rejection and development of graftvasculopathy (CAV) after heart transplantation (HTX). CMV diagnoses CMV-PCR prophylaxis/treatment valganciclovir have used since 2002. The aim this analysis was to evaluate their impact on CAV the long-term outcome transplantation. Methods: 384 adult 1-month survivors HTX (median age 55a, 24% female, transplanted between 2002 2012) were included. high-risk patients (Recipient-/Donor+)...
376 Background: Genetic lesions that drive prostate cancer (PCa) development are able to modify the immune response and tumor infiltrating subsets, resulting in progression. We investigated profile of microenvironment PCa by high dimensional single cell analysis. Methods: conducted an profiling study based on integrated RNA sequencing multiparametric flow cytometry order dissect landscape PCa. CD45+ cells tumoral adjacent non tissues were isolated from patients with who underwent software...