A5040527097- Fish Ecology and Management Studies
- Fish Biology and Ecology Studies
- Hydrology and Sediment Transport Processes
- Fish biology, ecology, and behavior
- Water Quality Monitoring Technologies
- Obstructive Sleep Apnea Research
- Underwater Vehicles and Communication Systems
- Aquaculture disease management and microbiota
- Marine and fisheries research
- Water Quality and Resources Studies
- Ichthyology and Marine Biology
- Aquatic Invertebrate Ecology and Behavior
- Reproductive biology and impacts on aquatic species
- Prostate Cancer Treatment and Research
- Tracheal and airway disorders
- Educational Assessment and Improvement
- Innovative Teaching and Learning Methods
- Underwater Acoustics Research
- Social and Intergroup Psychology
- Arctic and Antarctic ice dynamics
- Hydraulic flow and structures
- School Choice and Performance
- Physiological and biochemical adaptations
- Psychometric Methodologies and Testing
- Environmental DNA in Biodiversity Studies
Guy's and St Thomas' NHS Foundation Trust
2014-2023
Pacific Northwest National Laboratory
2011-2022
West Coast University
2019
Battelle
2001-2018
University of Minnesota Medical Center
2018
National Math and Science Initiative
2017
McGill University
2016
North West London Pathology
2016
Columbia University
2009-2013
Peterborough City Hospital
2012
Resistance to androgen receptor (AR) blockade in castration-resistant prostate cancer (CRPC) is associated with sustained AR signaling, including through alternative splicing of (AR-SV). Inhibitors transcriptional coactivators that regulate activity, the paralog histone acetyltransferase proteins p300 and CBP, are attractive therapeutic targets for lethal cancer. Herein, we validate targeting p300/CBP as a strategy describe CCS1477, novel small-molecule inhibitor conserved bromodomain. We...
Abstract Aims To determine the efficacy and patient perception of various transfer procedures from paediatric to adult diabetes services. Methods Comparison between four districts in Oxford Region employing different methods, by retrospective study case records interviews patients recently transferred clinics. The main outcome measures were age at transfer, clinic attendance rates, HbA 1c measurements questionnaire responses. Results Two hundred twenty‐nine subjects (57% males) > 18 years...
Swimming performance was compared among groups of juvenile rainbow trout Oncorhynchus mykiss (5–10 g) with and without intraperitoneally implanted radio transmitters. The generally accepted rule 2% body weight : transmitter extended to a 6–12% ratio, swimming not altered by the presence or effects operation. Also, no relationship found between fish its examined. Although we affected implantation transmitters weighing up 12% weight, changes in behavior were evaluated. We suggest further...
Fishes inhabiting streams and rivers in the interior of North America experience a continental climate. Water temperatures reach 0 °C winter are high summer. There is marked seasonal cycle discharge. These circumstances make groundwater crucial component river habitats. Groundwater can influence distribution, reproductive success, biomass productivity, behaviour movements fishes, especially important Winter flows minimal affected by ice. In winter, importance increases northwards. provides...
Abstract Stream‐dwelling fish face highly‐variable environmental conditions from fall to winter due fluctuations in water temperatures, discharge, and ice conditions. We provide an in‐depth description of the interactions between these complex behaviors stream‐dwelling salmonids during winter. Fisheries managers should be aware that confront order make appropriate management decisions. Diverse habitats, including deep pools with low velocities, coarse rock substrate, abundant cover, as well...
ABSTRACT Freshwater fishes are one of the most imperiled groups vertebrates, and population declines alarming in terms biodiversity to communities that rely on fisheries for their livelihood nutrition. One activity associated with freshwater fish populations is water resource development, including dams, weirs, hydropower facilities. Fish passing through irrigation hydro infrastructures during downstream migration experience a rapid decrease pressure, which can lead injuries (barotrauma)...
Fall and winter movements of habitat use by cutthroat trout Oncorhynchus clarki were studied with radiotelemetry in low, mid, high altitudes a river system to evaluate the timing extent shifts when fish moved from summer feeding areas overwintering areas. The 20 monitored August November 1991, 17 October December 1992. Cutthroat out habitats mid-September, many made two-stage shift that was associated anchor ice formation. When excluded fall ice, they less likely be influenced frazil ice:...
Abstract A proportion of juvenile Chinook salmon Oncorhynchus tshawytscha and other salmonids travel through one or more turbines during their seaward migration in the Columbia Snake rivers. There is limited information on how these fish respond to hydraulic pressures found turbine passage events. We exposed varied acclimation subsequent exposure mimic large Kaplan turbines. Additionally, we abiotic (total dissolved gas rate pressure change) biotic factors (condition factor, length, weight)...
We introduce a method for hydro turbine biological performance assessment (BioPA) to bridge the gap between field and laboratory studies on fish injury engineering design. Using this method, suite of indicators is computed based simulated data from computational fluid dynamics (CFD) model proposed Each indicator measure probability exposure certain dose an mechanism. If relationship mechanism (stressor) frequency (dose–response) known or studies, likelihood design can be indicator. By...
Abstract Acoustic telemetry is the primary method to actively track aquatic animals for behavioral studies. However, small storage capacities of batteries used in transmitters limit time that implanted can be studied. In this research, we developed and implemented a battery-free acoustic transmitter uses flexible piezoelectric beam harvest energy from fish swimming as power source. The sends out unique identification code with sufficiently strong signal (150 dB, ref: 1 μPa at meter) has...
Semaphorins are a large class of secreted or membrane-associated proteins that act as chemotactic cues for cell movement via their transmembrane receptors, plexins. We hypothesized the function semaphorin signaling pathway in control migration could be harnessed by cancer cells during invasion and metastasis. now report 13 somatic missense mutations cytoplasmic domain Plexin-B1 gene. Mutations were found 89% (8 9) prostate bone metastases, 41% (7 17) lymph node 46% (41 89) primary cancers....
Abstract This study assessed performance of seven suture types in subyearling Chinook salmon Oncorhynchus tshawytscha implanted with acoustic microtransmitters and held at two water temperatures (12°C 17°C). Nonabsorbable (Ethilon) absorbable (Monocryl) monofilament sutures nonabsorbable (Nurolon silk) (Vicryl, Vicryl Plus, Rapide) braided were used to close incisions salmon. When differences existed among types, tag retention generally highest for sutures. Wound inflammation ulceration...
States have moved rapidly over the past 20 years to institute systems of standards and assessments. State assessments in particular take on added importance at high school level as they are required for graduation by an increasing number states. Federal legislation mandating testing also serves increase stakes impact state exams. Many states using exams postsecondary purposes, although content criterion validity these relation students' post-high pursuits is not well documented. Though no...
The aim of this study was to examine the prevalence androgen receptor (AR) amplification in metastases bone and other sites patients with hormone-refractory prostate cancer (HRPC) compare these findings those pretreatment primary tumour samples from same patients. Tissue 24 HRPC available for study, together 13 specimens. AR gene copy number X-chromosome were assessed by fluorescence situ hybridization (FISH) using a SpectrumOrange-labelled probe at locus Xq11-13 SpectrumGreen-labelled...
Movement of radio‐tagged riverine brown trout Salmo trutta , white sucker Catostomus commersoni and common carp Cyprinus carpio in the Grand River, Ontario, was minimal during winter except periods high water discharge or break‐up river ice. Ice flooding occur when southern air masses penetrate northwards as temperatures increase spring. Both suckers moved longest distances, generally a downstream direction, ice break‐up. Brown less these times. All three species had positive relationships...
Objectives To examine incidence, mortality and survival trends in England Wales for testicular cancer, using the recently developed national cancer databases. Methods The directly age‐standardized incidence rates were calculated period 1971–97 years 1971–99. Trends data then assessed, including influence of social deprivation on survival. Results number newly diagnosed cases carcinoma increased from almost 650 to 1400. 2.9 per 100 000 1971 5.4 1997, an increase 88% over 26 years. There was a...