A5060274143- Platelet Disorders and Treatments
- Blood groups and transfusion
- Heparin-Induced Thrombocytopenia and Thrombosis
- Hemophilia Treatment and Research
- Blood Coagulation and Thrombosis Mechanisms
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Venous Thromboembolism Diagnosis and Management
- Renal Diseases and Glomerulopathies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Microwave Engineering and Waveguides
- Antenna Design and Analysis
- Advanced Antenna and Metasurface Technologies
- Blood properties and coagulation
- Erythropoietin and Anemia Treatment
- Chronic Kidney Disease and Diabetes
- Intramuscular injections and effects
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Head and Neck Cancer Studies
- Natural Compounds in Disease Treatment
- Congenital Heart Disease Studies
- Millimeter-Wave Propagation and Modeling
- Cervical Cancer and HPV Research
The University of Texas Southwestern Medical Center
2023-2024
Cook Children's Health Care System
2024
Birmingham Women’s and Children’s NHS Foundation Trust
2024
Medical College of Wisconsin
1999-2023
Versiti Blood Center of Wisconsin
2017-2023
Southwestern Medical Center
2023
Children's Hospital of Wisconsin
2019
Nationwide Children's Hospital
2014-2017
Harvard University
2017
The Ohio State University
2014-2016
Menstruating women, with or without underlying bleeding disorders, are at increased risk for developing iron deficiency-related fatigue, even in the absence of anemia. Oral therapy has limitations which include poor absorption and non-adherence due to gastrointestinal side effects. We performed a prospective clinical trial post-menarchal adolescent females iron-deficiency mild anemia fatigue who received standardized regimen intravenous sucrose. The baseline mean (SD) hemoglobin was 11.96 g...
Nephrotic syndrome is characterized by massive proteinuria and injury of specialized glomerular epithelial cells called podocytes. Studies have shown that, whereas low-concentration thrombin may be cytoprotective, higher concentrations contribute to podocyte injury. We others demonstrated that ex vivo plasma generation enhanced during nephrosis, suggesting nephrotic progression. Moreover, nonspecific inhibition has been decrease in animal models. thus hypothesized contributes a...
Thrombotic disease, a major life-threatening complication of nephrotic syndrome, has been associated with proteinuria and hypoalbuminemia severity. However, it is not fully understood how disease severity correlates the acquired hypercoagulopathy syndrome. Without this knowledge, utility and/or as biomarkers thrombotic risk remains limited. Here, we show that two well established ex vivo assays, thrombin generation rotational thromboelastometry, are highly correlated in puromycin...
Abstract Background Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is caused by antibodies against human platelet antigens (HPA). However, in many cases that meet clinical criteria for the condition, maternal sera do not have HPA antibodies. In studies examining whether leukocyte antigen (HLA) cause FNAIT, results are limited inconclusive. This study sought to examine clinically suspected FNAIT with absent had different HLA antibody strength specificity compared controls. Study...
Abstract Venous thromboembolism (VTE) is being increasingly recognized in children with sickle cell disease (SCD). In a retrospective cohort study, we identified bilateral central venous catheter (CVC) placement as an independent risk factor for VTE. At our institution, the only indication CVC SCD erythrocytapheresis. To investigate impact of erythrocytapheresis on coagulation, measured levels natural anticoagulants 11 patients chronic erythrocytapheresis, immediately before and after...
Aortopulmonary window is an opening between the aorta and pulmonary trunk. Two distinct separated semilunar valves must exist to establish diagnosis of aortopulmonary window, this defect should be differentiated from truncus arteriosus. generally diagnosed by echocardiography or Angiocardiography. The authors present two cases helical CT.
Abstract Introduction There are a significant number of patients with mucocutaneous bleeding, specifically heavy menstrual bleeding (HMB), who do not have diagnosed disorder. These receive nontargeted interventions and may suboptimal treatments. Functional assays, particularly for fibrinolytic rare platelet function defects, robust readily available. Aim We aimed to prospectively evaluate the prevalence genetic defects associated disorders describe alterations coagulation fibrinolysis in...
<h3>Background</h3> Non-cystic fibrosis (CF) bronchiectasis is an under-served, under-researched disease with significant morbidity and poor quality-of-life in affected children young people (CYP), (Chang:ERJ:2021). Ethnicity socio-economic disparities contribute to adverse health outcomes (Spencer:BMJ Open:2015). <h3>Aims</h3> This study aims describe the clinical characteristics of a cohort CYP varying ethnic deprivation backgrounds managed at regional multidisciplinary paediatric service...
Heparin-induced thrombocytopenia (HIT) is an immune-mediated prothrombotic disorder characterized by a drop in platelet count and increased risk of thromboembolic events. The accurate diagnosis HIT involves clinical assessment laboratory testing with well-characterized functional tests. Recent research has shown the potential investigating procoagulant formation induced antibodies. To successfully implement these assays laboratories, careful consideration technical preanalytical factors...