A5102922715- Blood groups and transfusion
- Hemoglobinopathies and Related Disorders
- CAR-T cell therapy research
- Neonatal Health and Biochemistry
- Platelet Disorders and Treatments
- Erythrocyte Function and Pathophysiology
- Childhood Cancer Survivors' Quality of Life
- Adolescent and Pediatric Healthcare
- Immune Cell Function and Interaction
- Blood disorders and treatments
- Blood properties and coagulation
- Vaccine Coverage and Hesitancy
- Iron Metabolism and Disorders
- Lymphoma Diagnosis and Treatment
- Respiratory viral infections research
- Polyomavirus and related diseases
- Healthcare Systems and Technology
- Nanowire Synthesis and Applications
- Methemoglobinemia and Tumor Lysis Syndrome
- Abdominal Trauma and Injuries
- Congenital Diaphragmatic Hernia Studies
- Biosimilars and Bioanalytical Methods
- Misinformation and Its Impacts
- Acute Lymphoblastic Leukemia research
- Integrated Circuits and Semiconductor Failure Analysis
Children's Hospital of Philadelphia
2024-2025
St. Michael's Hospital
2013-2024
Hospital for Sick Children
2010-2024
SickKids Foundation
2006-2024
University of Maryland, Baltimore
2021-2024
University of Toronto
2006-2022
Unity Health Toronto
2022
St Michael’s Hospital
2020-2021
Canada Research Chairs
2020
Palmetto Hematology Oncology
2013
Summary Hereditary spherocytosis (HS) is a common inherited haemolytic anaemia attributed to disturbances in five different red cell membrane proteins. We performed retrospective study of 166 children with HS and describe the clinical phenotype according genotype. In 160/166 (97%) disease‐causing mutation was identified. Pathogenic variants ANK1 , SPTB SLC4A1 SPTA1 were found 49%, 33%, 13% 5% patients. Children ‐HS had mildest phenotype, showing highest haemoglobin ( P < 0·001), lowest...
T cells expressing chimeric antigen receptors (CARs) have shown remarkable therapeutic activity against different types of cancer. However, the wider use CAR has been hindered by potential for life-threatening toxicities due to on-target off-tumor killing low amounts target antigen. CD229, a signaling lymphocyte-activation molecule (SLAM) family member, previously identified as cell–mediated treatment multiple myeloma (MM) its high expression on surfaces MM cells. CD229 effective clearance...
Abstract Background Aggressive B cell lymphoma with secondary central nervous system (CNS) involvement (SCNSL) carries a dismal prognosis. Chimeric antigen receptor (CAR) T cells (CAR-T) targeting CD19 have revolutionized the treatment for lymphomas; however, only single cases CNS manifestations successfully treated CAR-T been reported. Methods We prospectively enrolled 4 patients SCNSL into our study to assess clinical responses and monitor immunity. Results Two of four SNCSL responded...
Haemolytic disease of the newborn (HDN) can be associated with significant morbidity. Prompt treatment intensive phototherapy (PT) and exchange transfusions (ETs) dramatically improve outcomes. ET is invasive risks. Intravenous immunoglobulin (IVIG) may an alternative therapy to prevent use ET. An international panel experts was convened develop evidence-based recommendations regarding effectiveness safety IVIG reduce need for ETs, neurocognitive outcomes, bilirubin level, frequency red...
Post-transplant lymphoproliferative disorder (PTLD) is a potentially fatal complication following kidney transplantation, and there critical unmet need for PTLD treatments associated with more pronounced durable responses. To date, reports on the use of CD19-targeted chimeric antigen receptor (CAR) T (CAR-T) cells in patients after solid organ transplant (SOT) have been anecdotal, clinical presentations outcomes heterogenous, longitudinal analysis CAR-T cell expansion persistence has not...
ABSTRACT Chimeric antigen receptor (CAR) T cells are an effective treatment for some blood cancers. However, the lack of tumor-specific surface antigens limits their wider use. We identified a set that limited in expression to cancer and central nervous system (CNS). developed CAR against one these antigens, LINGO1, which is widely expressed Ewing sarcoma (ES). To prevent CNS targeting, we engineered LINGO1 lacking integrin ⍺ 4 (A4 ko ), adhesion molecule essential migration across...
Human metapneumovirus (hMPV) has recently emerged as an important cause of lower respiratory tract infections in hospitalized children, causing severe pneumonia and failure among immunocompromised patients. We retrospectively examined 30 children diagnosed with cancer whose nasopharyngeal swabs were positive for hMPV by direct fluorescent testing over a 5-year period. In 16/30 (53.3%) infection was confined to the upper tract, whereas occurred 46.7%. The median duration illness 6.5 days...
Asplenia and hyposplenia (a/hyposplenia) are associated with increased morbidity mortality from complications including infection. The recommended measures to reduce the risks infection include patient education, vaccination early initiation of antibiotic therapy for fever. Despite these recommendations, there is poor adherence best practice management patients asplenia or (PWA/H). We present development methodology pilot data a quality improvement project that explored whether programme...
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Abstract Several factors unique to Fanconi anemia (FA) limit the success of allogeneic hematopoietic stem cell transplantation (HSCT) in this population. In report, we describe a multi‐center pilot study five consecutive FA patients with high‐risk features for transplant prepared fludarabine, without radiation. Four engrafted quickly, experienced minimal toxicity and are well at 43–65 months post‐transplant. One patient had C‐mismatched unrelated donor unsustained engraftment. This...
Abstract Cystic partially differentiated nephroblastoma (CPDN) has low malignant potential. We report a 1‐year‐old with stage III CPDN of the right kidney that recurred following radical nephrectomy and chemotherapy. There was evidence tumor spillage pre‐operatively intra‐operatively. During chemotherapy disease in omentum peritoneum. Pathology recurrent resected cysts revealed more biphasic without blastemal elements. It appears our patient led to dissemination disease. Chemotherapy failed...