A5020448169- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Eosinophilic Esophagitis
- Drug-Induced Adverse Reactions
- Respiratory and Cough-Related Research
- Asthma and respiratory diseases
- Infant Health and Development
- Contact Dermatitis and Allergies
- Eosinophilic Disorders and Syndromes
- Urticaria and Related Conditions
- Pharmacovigilance and Adverse Drug Reactions
- Obesity, Physical Activity, Diet
- Child Nutrition and Feeding Issues
- Mobile Health and mHealth Applications
- Pediatric health and respiratory diseases
- Mast cells and histamine
- Breastfeeding Practices and Influences
- Ginseng Biological Effects and Applications
- Mitochondrial Function and Pathology
- Immune Response and Inflammation
- Sesame and Sesamin Research
- Urban, Neighborhood, and Segregation Studies
- Polyamine Metabolism and Applications
- Pregnancy and Medication Impact
- NF-κB Signaling Pathways
University of British Columbia
2018-2025
British Columbia Children's Hospital
2018-2025
Children's Research Hospital
2023
University of Alberta
2023
National Institute of Allergy and Infectious Diseases
2022
Hospital for Sick Children
2016-2020
St. Michael's Hospital
2014
Because of its favorable safety, sublingual immunotherapy (SLIT) for food allergy has been proposed as an alternative treatment those in whom oral (OIT) is higher risk-older children, adolescents, adults, and with a history severe reactions. Although safe, SLIT shown to be less effective than OIT.
Sublingual immunotherapy (SLIT) is a safe, effective therapy for the treatment of food allergy. Studies demonstrating SLIT efficacy have primarily used pharmaceutical glycerinated extracts administration allergens, which may limit accessibility due to extract cost and availability. To develop novel sample protocols resources preparation grocery-sourced real solutions, could help more clinicians incorporate into their practice increase this treatment. Secondly, describe our site's experience...
Abstract Background Current management of food protein-induced enterocolitis syndrome (FPIES) involves strict avoidance the offending for 12–18 months, followed by oral challenge (OFC) under physician supervision. OFCs are resource-intensive and there is a lack universal standardized protocol FPIES. Prolonged may increase risk IgE-mediated allergy, particularly in atopic patients. Food ladders have shown success promoting accelerated tolerance patients with allergy. Our case series evaluated...
Previous studies support the effectiveness of sesame oral immunotherapy (S-OIT) in patients >4 years old using maintenance doses 1200 mg protein. However, tahini is often not palatable to children, and high-maintenance may be possible for preschoolers. We studied safety outcomes preschoolers with allergy who underwent low-dose S-OIT 200 Preschoolers allergy, a history objective reaction sesame, either positive skin prick test result (wheal diameter ≥3 mm) or sesame-specific IgE level ≥0.35...
Abstract Background Penicillin allergy is a commonly listed medication despite rare overall incidence. Many patients erroneously have this label, which has personal, health, and societal costs. delabelling requires an oral challenge, can be rate limiting step in the de-labeling process; even more relevant with reduction of in-person visits during COVID-19 pandemic. Objective To identify utility broader applicability using virtually supported platform, initially adopted given restrictions, to...
An understanding of how patient characteristics such as age, baseline peanut-specific IgE, and atopic comorbidities may influence potential safety outcomes during peanut oral immunotherapy (P-OIT) could aid in shared decision making between clinicians families.This study explored the relationship reactions P-OIT using a large sample size to better understand risk factors influencing safety.Data were obtained from Food Allergy Immunotherapy (FAIT) registry, which collects real-world OIT data...
Inaccurate penicillin allergy labels lead to inappropriate antibiotic prescriptions and harmful patient consequences. System-wide efforts are needed remove incorrect labels, but more health services research is required on how best deliver these services.Data was extracted from five hospitals in Vancouver, British Columbia, Canada October 2018-May 2022. The primary outcomes of this study were outline de-labelling protocol designs, identify the roles various healthcare professionals protocols...
Clinical Implications•Infants at risk for development of peanut allergy have very limited access to allergist assessment the prevention during COVID-19 pandemic. Virtually supported infant home introduction represents a practical and safe alternative avoid delays in introduction. •Infants Recently published North American guidelines management allergic disease pandemic recommend service adjustments such as virtual visits or postponing appointments.1Shaker M.S. Oppenheimer J. Grayson M....
BackgroundOral immunotherapy is an effective treatment for food allergies; however, its use in clinical practice limited by resources and lack of standardized protocols foods other than peanut. Previous studies have suggested that shrimp has a higher threshold reaction allergenic foods, suggesting it may be safe to directly administer maintenance doses immunotherapy.MethodsChildren aged 3–17 years who had 1) skin prick test ≥3 mm and/or specific IgE level ≥0.35 kU/L convincing objective...
Ginseng is a perennial herb used in traditional Chinese medicine, which has become increasingly popular world-wide due to its proposed medicinal effects. There are two major species of ginseng, Panax ginseng (Korean or Asian ginseng), and quinquefolius (American ginseng). Although cases allergy Korean have been reported adults, there no American pediatric patients. We present unique patients with suspected allergic reactions ginseng. The first patient 6-year-old girl who presented the...
A six-year-old boy with autism spectrum disorder presented to the emergency department a one-week history of left hip pain and limping. His associated symptoms included fever, rhinorrhea cough. Bilateral knee radiographs were normal, he was discharged home diagnosis
Clinical Implications•The coronavirus disease 2019 (COVID-19) pandemic has limited access to in-person allergist assessments. Virtually supported food introduction can be a feasible and safe approach avoid delays in high-risk individuals, by positive experience high satisfaction rates for both caregivers allergists. •The The resulted the modification postponement of many allergy clinic services.1Shaker M.S. Oppenheimer J. Grayson M. Stukus D. Hartog N. Hsieh E.W.Y. et al.COVID-19:...
Abstract Cow’s milk allergy (CMA) is one of the most common food allergies in first years life, with worldwide prevalence estimated to range from 2% 5%. While majority children CMA will eventually develop tolerance cow’s proteins (it that >75% by age 3 years, and >90% 6 years), selection an appropriate (CM) alternative for those vital ensure adequate growth development during childhood. The increasing number CM products on commercial market markedly different nutritional...
The innate immune system allows for rapid recognition of pathogens. Toll-like receptor (TLR) signaling is a key aspect the response, and interleukin-1 receptor-associated kinase 4 (IRAK4) plays vital role in TLR cascade. Each recognizes distinct set pathogen-associated molecular patterns (PAMPs) that encompass conserved microbial components such as lipopolysaccharides flagellin. Upon binding PAMPs activation, intracellular domains initiate oligomerization myeloid differentiation primary...