A5055720475- Cancer Genomics and Diagnostics
- SARS-CoV-2 and COVID-19 Research
- Food Allergy and Anaphylaxis Research
- COVID-19 Clinical Research Studies
- Glioma Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Child Nutrition and Feeding Issues
- Eosinophilic Esophagitis
- Mycobacterium research and diagnosis
- Brain Metastases and Treatment
- Cancer Diagnosis and Treatment
- Food Security and Health in Diverse Populations
- Genomics and Phylogenetic Studies
- COVID-19 epidemiological studies
- SARS-CoV-2 detection and testing
- Infectious Diseases and Mycology
- Long-Term Effects of COVID-19
- Animal Virus Infections Studies
- Lung Cancer Research Studies
- CRISPR and Genetic Engineering
- Dental Health and Care Utilization
- Vaccine Coverage and Hesitancy
- COVID-19 and healthcare impacts
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
Stanford University
2022
Sinai Health System
2021-2022
University of California, San Francisco
2015-2021
British Columbia Children's Hospital
2018-2021
University of British Columbia
2018-2021
University of British Columbia Hospital
2020
Abbott (United States)
2020
Global Viral
2020
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has spread globally, with >365,000 cases in California as of 17 July 2020. We investigated the genomic epidemiology SARS-CoV-2 Northern from late January to mid-March 2020, using samples 36 patients spanning nine counties and Grand Princess cruise ship. Phylogenetic analyses revealed cryptic introduction at least seven different lineages into California, including epidemic WA1 strains...
Abstract Given the limited availability of serological testing to date, seroprevalence SARS-CoV-2-specific antibodies in different populations has remained unclear. Here, we report very low SARS-CoV-2 two San Francisco Bay Area populations. Seroreactivity was 0.26% 387 hospitalized patients admitted for non-respiratory indications and 0.1% 1,000 blood donors early April 2020. We additionally describe longitudinal dynamics immunoglobulin-G (IgG), immunoglobulin-M (IgM), vitro neutralizing...
ABSTRACT An outbreak of novel betacoronavirus, SARS-CoV-2 (formerly named 2019-nCoV), began in Wuhan, China December 2019 and the COVID-19 disease associated with infection has since spread rapidly to multiple countries. Here we report development DETECTR, a rapid (∼30 min), low-cost, accurate CRISPR-Cas12 based lateral flow assay for detection from respiratory swab RNA extracts. We validated this method using contrived reference samples clinical infected US patients demonstrated comparable...
ABSTRACT We report very low SARS-CoV-2 seroprevalence in two San Francisco Bay Area populations. Seropositivity was 0.26% 387 hospitalized patients admitted for non-respiratory indications and 0.1% 1,000 blood donors. additionally describe the longitudinal dynamics of immunoglobulin-G, immunoglobulin-M, vitro neutralizing antibody titers COVID-19 patients. Neutralizing antibodies rise tandem with immunoglobulin levels following symptom onset, exhibiting median time to seroconversion within...
Abstract The COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 has spread globally, resulting in >300,000 reported cases worldwide as of March 21st, 2020. Here we investigate genetic diversity and genomic epidemiology Northern California using samples from returning travelers, cruise ship passengers, community transmission with unclear infection sources. Virus genomes were sampled 29 patients diagnosed Feb 3rd through Mar 15th. Phylogenetic analyses revealed at least 8...
Metagenomic next-generation sequencing (mNGS) of body fluids is an emerging approach to identify occult pathogens in undiagnosed patients. We hypothesized that metagenomic testing can be simultaneously used detect malignant neoplasms addition infectious pathogens.
<h3>Importance</h3> Cerebrospinal fluid (CSF) cytologic testing and flow cytometry are insensitive for diagnosing neoplasms of the central nervous system (CNS). Such clinical phenotypes can mimic infectious autoimmune causes meningoencephalitis. <h3>Objective</h3> To ascertain whether CSF metagenomic next-generation sequencing (mNGS) identify aneuploidy, a hallmark malignant neoplasms, in difficult-to-diagnose cases CNS neoplasm. <h3>Design, Setting, Participants</h3> Two case-control...
In the context of food allergy, excessive parental anxiety can be maladaptive and lead to unnecessary restriction social activities. No validated tool exists measure allergy-associated (FAAA). This study sought explore factors associated with FAAA, determine sensitivity specificity using generic state measure-State-Trait Anxiety Inventory (STAI) versus whether tools for generalized or allergy-specific quality life (QoL) could used as surrogates FAAA.Canadian parents food-allergic children...
ABSTRACT COVID-19 primarily affects the lungs, but evidence of systemic disease with multi-organ involvement is emerging. Here, we developed a blood test to broadly quantify cell, tissue, and organ specific injury due COVID-19, using genome-wide methylation profiling circulating cell-free DNA in plasma. We assessed utility this identify subjects severe two independent, longitudinal cohorts hospitalized patients. Cell-free was performed on 104 plasma samples from 33 patients compared other...
Abstract In early-to-mid March 2020, 20 of 46 (43%) COVID-19 cases at a tertiary care hospital in San Francisco, California were travel related. Cases significantly associated with to either Europe (odds ratio, 6.1) or New York 32.9). Viral genomes recovered from 9 12 (75%) co-clustered lineages circulating Europe.
We report the draft genome sequence of Mycobacterium obuense strain UC1 from a patient sputum sample. This is first obuense, rapidly growing scotochromogenic mycobacterium.
We report the draft genome sequence of Mycobacterium elephantis strain Lipa from a sputum sample patient with pulmonary disease. This is first M. elephantis, rapidly growing mycobacterium.
Abstract Longer time to diagnosis for patients with eosinophilic esophagitis can lead adverse patient outcomes, but the length of diagnostic delay has not been quantified in Canada. Our study defines (TTD) pediatric British Columbia and identifies factors that predict increased diagnosis. The median TTD was 21 months (1.75 years; IQR = 7, 45) a age at EoE 105 (8.75 44, 156). Caucasians experienced significantly longer compared other ethnicities (24 (IQR 52) 12 4.5, 23) respectively, p...
We report the draft genome sequence of Mycobacterium arupense strain GUC1 from a sputum sample patient with bronchiectasis. This is first arupense, rapidly growing nonchromogenic mycobacteria.