A5057535744- Eosinophilic Esophagitis
- Eosinophilic Disorders and Syndromes
- Food Allergy and Anaphylaxis Research
- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Clinical Nutrition and Gastroenterology
- Child Nutrition and Feeding Issues
- Child Nutrition and Water Access
- Gastrointestinal disorders and treatments
- Intestinal Malrotation and Obstruction Disorders
- Nutrition and Health in Aging
- Organ Transplantation Techniques and Outcomes
- Allergic Rhinitis and Sensitization
- Eating Disorders and Behaviors
- Immunodeficiency and Autoimmune Disorders
- Helicobacter pylori-related gastroenterology studies
- Polyamine Metabolism and Applications
- Gastrointestinal motility and disorders
- Renal Transplantation Outcomes and Treatments
- Cancer-related gene regulation
- Dental Education, Practice, Research
- Pediatric health and respiratory diseases
- Microscopic Colitis
- Liver Disease and Transplantation
- Infant Nutrition and Health
British Columbia Children's Hospital
2016-2025
University of British Columbia
2016-2025
SickKids Foundation
2013
University of Toronto
2013
We sought to determine the prevalence of adrenal suppression (AS) in children with eosinophilic esophagitis treated oral viscous budesonide (OVB). This was a retrospective review quality assurance initiative, whereby all our center OVB for ≥3 months were referred over an 18-month time frame endocrine assessment including 1 μg adrenocorticotropic hormone stimulation test. Fourteen 19 complied referral; these 14 children, 6 (43%) had suboptimal stimulated cortisol (range 343-497 nmol/L, mean...
Abstract Background Eosinophilic gastritis (EoG) involves eosinophilic infiltration of the stomach, leading to symptoms without identifiable secondary causes. It can occur with Esophagitis (EoE) or independently (non-EoE EGID). Common include abdominal pain, vomiting, fatigue, and edema. Recent North American Society Pediatric Gastroenterology, Hepatology Nutrition/European Nutrition (NASPGHAN/ESPGHAN) criteria (Jan 2024) define EoG as >30 eosinophils per high-power field (hpf). Aims...
Abstract Background Esoinophilic Esophagitis (EoE) is a chronic condition that requires endoscopy and biopsies for diagnosis treatment evaluation. In pediatrics, anaesthesiology OR based sedation standard practice, but it resource intense, full fasting, involves some risk. Trans-Nasal Endoscopy (TNE) with virtual reality (VR) distraction has successfully been used evaluated at multiple Children’s Hospitals in the US. It uses thin endoscopes to obtain esophageal biopsies. This service not...
Abstract Background Healthcare transition for pediatric patients with chronic gastrointestinal diseases is a coordinated process that requires multidisciplinary collaboration to improve an otherwise challenging time and their families. While this has been explored in other areas such as inflammatory bowel disease, the experience not well characterized eosinophilic esophagitis (EoE). Aims To better understand characterize experiences attitudes of from adult care EoE British Columbia. Methods...
Cow's milk is a commonly implicated trigger in eosinophilic esophagitis (EoE). Exclusive cow's avoidance has been reported previously, but the degree of elimination required for remission unclear. Strict food may confer risk developing immunoglobulin E (IgE)-mediated allergy. The goal this study was to evaluate effectiveness (CME) children with EoE and compare responses strict liberalized CME diets.Children (≤16 years) diagnosed who were treated exclusive diets evaluated clinically...
Eosinophilic esophagitis (EoE) is considered a TH2-mediated food allergy disease that leads to submucosal esophageal fibrosis and strictures. Recent studies focused on adults with EoE identified strong association elevated IgG4 immunostaining. Our study aimed determine the of in pediatric patients.Using our local research registry, we 41 adequate biopsies from patients. We used 10 age- sex-matched patients no diagnostic abnormalities at endoscopy or biopsy. Using monoclonal antibody...
Abstract Background This study constitutes a secondary analysis of prospective cohort aiming to evaluate the potential correlation between nutritional risk and status at admission with occurrence post-discharge complications hospital readmissions in children receiving care high resource Centres. Methods Data was collected from 5 Canadian tertiary pediatric Centers 2012 2016. Nutritional were evaluated validated tools (STRONGkids Subjective Global Nutrition Assessment [SGNA]) anthropometric...
Abstract Renal impairment is frequently compromised in patients with end‐stage liver disease and associated increased long‐term mortality post‐LT. In contrast to CNI, basiliximab an immunosuppressive agent minimal nephrotoxic potential. This study reviews the experience of a single pediatric transplant center's renal‐sparing approach use MMF compensate for delayed entry CNI children renal at time organ availability. There were no differences function between without pre‐LT within first year...
Recently, genetic associations have been described in intestinal transplants. Namely, Crohn's disease susceptibility gene NOD2 polymorphisms reported to be more prevalent patients with graft failure following transplantation (IT). Therefore, we sought determine if the signaling cascade, including NOD2, CARD9, RAC1 and ATG16L1 are associated (IF) or its complications. We carried out a cross-sectional study of 59 children IF 500 healthy Caucasian controls. Using Taqman platform determined...
OBJECTIVE Decision-making about antireflux procedures (ARPs) to treat gastroesophageal reflux disease in children with neurologic impairment and gastrostomy tubes is challenging likely influenced by physicians’ experience perspectives. This study will explore physician attitudes ARPs determine if there are relationships clinical practice personal characteristics. METHODS a national observational cross-sectional that used an electronic questionnaire addressing reported practice, regarding the...
Histologic diagnosis of eosinophilic esophagitis (EoE) involves peak eosinophil counts (PEC) being greater than 15 per high power field. The EoE Histology Scoring System (EoEHSS) was developed to comprehensively evaluate biopsies better predict symptom and endoscopy response; we aimed validate the EoEHSS in our provincial registry, where had not been employed.We reviewed 186 esophageal from 16 patients at follow-up. Statistical analyses were conducted quantify how grade scores correlate with...
The Canadian Federation of Medical Students (CFMS) believes that high-quality and sustainable health care depends on an adequate supply family physicians more must be done to address the current (and future) shortfall practising physicians. Almost 4.8 million Canadians do not
Abstract X-linked hypohidrotic ectodermal dysplasia (XLHED) is the most common form of dysplasia. Clinical and genetic heterogeneity between different types evidence incomplete penetrance variable expressivity increase potential for misdiagnosis. We describe a family with presenting symptoms affected siblings. In addition to classical signs hypohidrosis, hypotrichosis hypodontia, index patient—a 5 year old boy, also presented severe atopy phenotype that was not observed in other two...
We investigated the effectiveness of a novel, hunger-based outpatient tube weaning program for children with feeding-tube dependency. This interdisciplinary induced hunger via rapid reduction in tube-fed calories, followed by 2 weeks daily mealtime support and regular follow-up. Forty-one (6.9 months to 12.8 years) participated this retrospective cohort study. Before program, received median 90.0% (interquartile range [IQR]: 75.0%-100%) caloric intake feeds. At end 2-week 16.0% (IQR:...
Improving characterization of the narrowing phenotype in pediatric eosinophilic esophagitis (EoE). New EoE diagnoses from 2015 to 2018 were retrospectively identified Vancouver (BC), Northern Alberta (AB), Hamilton (ON), and Nova Scotia (NS). Incidence rates calculated using 2016 Federal census data. Clinical, endoscopic, histologic data gathered diagnosis until end follow-up period (fall 2019). The incidence patients less than 15 years old was 5.4 per 100,000 person-years. Of 332 new...