A5027938519- Acute Ischemic Stroke Management
- Epilepsy research and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Healthcare cost, quality, practices
- Neurology and Historical Studies
- Ethics in Clinical Research
- Emergency and Acute Care Studies
- Posttraumatic Stress Disorder Research
- Suicide and Self-Harm Studies
- Gun Ownership and Violence Research
- Artificial Intelligence in Healthcare and Education
- Pharmacological Effects and Toxicity Studies
- Intensive Care Unit Cognitive Disorders
- Cerebrovascular and Carotid Artery Diseases
- Hospital Admissions and Outcomes
- Innovations in Medical Education
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiac Arrest and Resuscitation
- Cerebrovascular and genetic disorders
- Intracranial Aneurysms: Treatment and Complications
- Healthcare Decision-Making and Restraints
- Neurosurgical Procedures and Complications
- Clinical Reasoning and Diagnostic Skills
- Stroke Rehabilitation and Recovery
- Dementia and Cognitive Impairment Research
University of California, San Francisco
2016-2025
University of Washington
2012-2022
Barrow Neurological Institute
2022
University of Maryland, Baltimore
2022
Epilepsy Foundation
2022
Universidad Católica de Santa Fe
2022
Neurology, Inc
2020-2021
Neurosciences Institute
2017-2021
University of California San Francisco Medical Center
2007-2021
University of Kentucky
2020
Metagenomic next-generation sequencing (NGS) of cerebrospinal fluid (CSF) has the potential to identify a broad range pathogens in single test.In 1-year, multicenter, prospective study, we investigated usefulness metagenomic NGS CSF for diagnosis infectious meningitis and encephalitis hospitalized patients. All positive tests on were confirmed by orthogonal laboratory testing. Physician feedback was elicited teleconferences with clinical microbial board surveys. Clinical effect evaluated...
Identifying infectious causes of subacute or chronic meningitis can be challenging. Enhanced, unbiased diagnostic approaches are needed.To present a case series patients with diagnostically challenging using metagenomic next-generation sequencing (mNGS) cerebrospinal fluid (CSF) supported by statistical framework generated from mNGS control samples the environment and who were noninfectious.In this series, data obtained CSF 94 noninfectious neuroinflammatory disorders 24 water reagent used...
Ling Mao; Huijuan Jin; Mengdie Wang; Yu Hu; Shengcai Chen; Quanwei He; Jiang Chang; Candong Hong; Yifan Zhou; David Xiaoping Miao; Yanan Li, MD, PhD; Bo Hu, PhD
Phil B. Fontanarosa, MD, MBA; Annette Flanagin, RN, MA; John Z. Ayanian, MPP; Robert O. Bonow, MS; Neil M. Bressler, MD; Dimitri Christakis, MPH; Mary L. Disis, S. Andrew Josephson, Melina R. Kibbe, Dost Öngür, PhD; Jay F. Piccirillo, Rita Redberg, Frederick P. Rivara, Kanade Shinkai, Clyde W. Yancy, MSc
<b><i>Background:</i></b> Imaging of the carotid arteries is important for evaluation patients with ischemic stroke or TIA. CT angiography (CTA) head and neck readily available can be part routine imaging patients. To evaluate accuracy CTA, authors compared degree stenosis found using CTA digital subtraction (DSA) in consecutive during a 3-year period. <b><i>Methods:</i></b> The included all interpretable DSA cervical from April 2000 to November 2002 at single academic medical center. This...
Transient ischemic attacks are common and important harbingers of subsequent stroke. Management varies widely, most published guidelines have not been updated in several years. We sought to create comprehensive, unbiased, evidence-based for the management patients with transient attacks.Fifteen expert panelists were selected based on objective criteria, using publication metrics that predicted nomination by practitioners field. Prior identified through systematic review, recommendations...
<h3>Background</h3> Rapidly progressive dementia has a variety of causes, including Creutzfeldt-Jakob disease (CJD) and neuronal voltage-gated potassium channel (VGKC) autoantibody–associated encephalopathy. <h3>Objective</h3> To describe patients thought initially to have CJD but found subsequently immunotherapy-responsive VGKC autoimmunity. <h3>Design</h3> Observational, prospective case series. <h3>Setting</h3> Department Neurology, Mayo Clinic, the Memory Aging Center, University...
Epilepsy is a common condition in the United States. It estimated that 1.2% of population or 3.4 million people have epilepsy. This figure may be underestimated because potential repercussions and stigma disclosing epilepsy.1 Studies shown with epilepsy are more likely to unemployed unable work, lower annual household incomes, obese physically inactive, less marry.2,3 People can poor overall health status, impaired intellectual physical functioning, elevated risk accidents injuries, negative...
Status epilepticus is a common neurologic emergency with significant associated morbidity, mortality, and health care costs, yet limited data exist detailing trends in status epilepticus-related hospitalizations mortality.To examine mortality.We performed 2 retrospective serial cross-sectional studies including 408 304 hospital visits using generalizable national from January 1, 1999, to December 31, 2010, the Centers for Disease Control Prevention Nationwide Inpatient Sample. death...
The NIH Stroke Scale (NIHSS) is widely used in stroke clinical care and trials. Certification its use, most commonly through rating of video vignettes, routinely required. To investigate the reliability NIHSS a representative sample raters, we examined results frequently certification examination.At invitation National Association, analyzed all raters who completed one two multiple patient videotaped examinations from 1998 to 2004. Total scores for each vignette were calculated ratings...
Background and Purpose— The relationship between subcortical ischemic vascular disease (SIVD) cognition in normal elderly is unclear, part because of methodological inconsistencies across studies. To clarify this relationship, the current study investigated a well characterized cognitively sample (≥55 years) with quantitative MRI psychometrically robust neuropsychological measures within multivariate model. Converging evidence suggests that SIVD selectively impairs frontal-executive tasks by...
Some patients diagnosed with transient ischemic attack (TIA) in the emergency department may actually have alternative diagnoses such as seizure, migraine, or other nonvascular spells. The ABCD2 score has been shown to predict subsequent risk of stroke TIA by physicians, but perhaps high scores simply separate those true from diagnoses. We investigated this hypothesis a cohort identified whose records were reviewed an expert neurologist.Among physicians 16 hospitals Kaiser-Permanente Medical...
Background and Purpose— Dizziness can herald a cerebrovascular event. The ABCD 2 score predicts the risk of stroke after transient ischemic attack partly by distinguishing from mimics. We evaluated whether this would also identify events among emergency department patients with dizziness. Methods— retrospectively identified consecutive adults presenting to university primary symptom dizziness, vertigo, or imbalance. Two neurologists independently reviewed medical records determine was caused...
Object Neurointensivists are specialists trained to manage all aspects of the intensive care unit (ICU) stay neurologically ill patients. No study date has examined role neurointensivists specifically in subarachnoid hemorrhage (SAH) management. This use a team-based neurointensivist co-management approach. Methods The authors reviewed cases involving patients with SAH admitted neurosurgical service during period more than 4 years. A comparison was made between those before and after...
Catheter ablation for ventricular tachycardia and premature complexes (PVCs) is common. of atrial fibrillation associated with a risk cerebral emboli attributed to cardioversions numerous lesions in the low-flow left atrium, but embolic has not been evaluated.We enrolled 18 consecutive patients meeting study criteria scheduled or PVC over 9-month period. Patients undergoing (LV) were compared control group those right only. excluded if they had implantable cardioverter defibrillators...
Current attempts to gauge the acute care needs of patients with dementia have not effectively addressed role caregivers, despite their extensive involvement in decisions about management.To determine whether caregiver depression is associated increased use emergency department (ED) among dementia.This longitudinal cohort study used data from Care Ecosystem study, a randomized clinical trial examining telephone-based supportive for and caregivers. Patients were 45 years or older any type...
The incidence of contrast-induced nephropathy was examined in 1,075 patients receiving routine CT angiography and perfusion brain imaging at a single institution. Fifty-two had creatinine rise > or =0.5 mg/dL. In four (0.37%), the administration IV contrast medium possibly contributed to renal failure. Two (0.19%) received temporary hemodialysis during hospitalization. neurovascular is low.
Background: Cerebral perfusion‐CT (PCT) is commonly used to image patients with suspected stroke, but PCT may also be useful in detecting abnormalities following seizure. Methods: We retrospectively identified who presented our stroke center between 2000 and 2008 acute, transient neurological deficits because of seizure received imaging within 72 h. compared the group abnormal post‐ictal a normal PCT. Patients were excluded from analysis if occurred secondary an acute process known alter...