A5053990255- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Pregnancy and preeclampsia studies
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Issues in Pregnancy
- Cardiac Ischemia and Reperfusion
- Alcohol Consumption and Health Effects
- Cardiac Arrest and Resuscitation
- Anesthesia and Neurotoxicity Research
- Birth, Development, and Health
- Maternal and fetal healthcare
- Cardiac Health and Mental Health
- Cardiovascular Effects of Exercise
- Substance Abuse Treatment and Outcomes
- Healthcare cost, quality, practices
- Reproductive Health and Contraception
- Global Maternal and Child Health
- Acute Myocardial Infarction Research
- Gestational Diabetes Research and Management
- Maternal and Perinatal Health Interventions
- Healthcare Systems and Technology
- Palliative Care and End-of-Life Issues
- Congenital heart defects research
- Cardiac, Anesthesia and Surgical Outcomes
- Mobile Health and mHealth Applications
University of Toronto
2013-2024
Sinai Hospital
2023
University of California, San Francisco
2016-2021
Queen's University
2018-2019
Harvard University
2014
Massachusetts Institute of Technology
2014
Harvard Stem Cell Institute
2014
Brigham and Women's Hospital
2014
Hospital for Sick Children
2011
<h3>Importance</h3> Atrial fibrillation (AF) affects 34 million people worldwide and is a leading cause of stroke. A readily accessible means to continuously monitor for AF could prevent large numbers strokes death. <h3>Objective</h3> To develop validate deep neural network detect using smartwatch data. <h3>Design, Setting, Participants</h3> In this multinational cardiovascular remote cohort study coordinated at the University California, San Francisco, smartwatches were used obtain heart...
Rationale: Neonatal mice have the capacity to regenerate their hearts in response injury, but this potential is lost after first week of life. The transcriptional changes that underpin mammalian cardiac regeneration not been fully characterized at molecular level. Objective: objectives our study were determine whether myocytes revert phenotype a less differentiated state during and systematically interrogate data identify validate regulators process. Methods Results: We derived core...
Background Alcohol consumption has been associated with atrial fibrillation ( AF ) in several epidemiologic studies, but the underlying mechanisms remain unknown. We sought to test hypothesis that an myopathy, manifested by echocardiographic left enlargement, explains association between chronic alcohol use and . Methods Results evaluated relationship cumulative risk of incident 5220 Offspring Original Framingham Heart Study participants (mean age 56.3 years, 54% women) size measurements....
Catheter ablation for ventricular tachycardia and premature complexes (PVCs) is common. of atrial fibrillation associated with a risk cerebral emboli attributed to cardioversions numerous lesions in the low-flow left atrium, but embolic has not been evaluated.We enrolled 18 consecutive patients meeting study criteria scheduled or PVC over 9-month period. Patients undergoing (LV) were compared control group those right only. excluded if they had implantable cardioverter defibrillators...
Patients' self-reports suggest that acute alcohol consumption may trigger a discrete atrial fibrillation (AF) event.To objectively ascertain whether heightens risk for an AF episode.A prospective, case-crossover analysis.Ambulatory persons in their natural environments.Consenting patients with paroxysmal AF.Participants were fitted continuous electrocardiogram (ECG) monitor and ankle-worn transdermal ethanol sensor 4 weeks. Real-time documentation of each alcoholic drink consumed was...
rIPC [remote IPC (ischaemic preconditioning)] has been shown to invoke potent myocardial protection in animal studies and recent clinical trials. Although the important role of PI3K (phosphoinositide 3-kinase)/Akt activation cardioprotection afforded by local is well described, our understanding intracellular signalling remains incomplete. We therefore examined hypothesis that mediated via PI3K/Akt/GSK3β (glycogen synthase kinase 3β) pathway, which associated with nuclear accumulation...
Background— Ascertainment of hospitalizations is critical to assess quality care and the effectiveness adverse effects various therapies. Smartphones, mobile geolocators that are ubiquitous, have not been leveraged ascertain hospitalizations. Therefore, we evaluated use smartphone-based geofencing track Methods Results— Participants aged ≥18 years installed a application programmed geofence all hospitals using global positioning systems cell phone tower triangulation trigger questionnaire...
Previous studies have shown that electroacupuncture (EA) can induce cardioprotection against ischemia-reperfusion (IR) injury, but its mechanisms are incompletely understood. We previously several other forms of remote preconditioning the heart work, at least in part, via release circulating cardioprotective factors into bloodstream, be dialyzed and subsequently to reduce IR injury isolated hearts. used same methods assess whether EA leads similar humoral cardioprotection. rabbits were...
<b>Objective</b> To investigate the relation between alcohol consumption and heart disease by using differences in county level sales laws as a natural experiment. <b>Design</b> Observational cohort study laws. <b>Setting</b> Hospital based healthcare encounters Texas, USA. <b>Population</b> 1 106 968 patients aged 21 or older who were residents of "wet" (no restrictions) "dry" (complete prohibition sales) counties admitted to hospital 2005 2010, identified Texas...
Early preterm birth (ie, at less than 34 weeks' gestation) confers a high risk for adverse health outcomes, yet no universal screening strategy exists, preventing targeted delivery of effective interventions.
Background Atrial refractoriness may be an important determinant of atrial fibrillation (AF) risk, but its measurement is not clinically accessible. Because the QT interval predicts incident AF and atrium ventricle share repolarizing ion currents, we investigated association between individual's effective refractory period (AERP). Methods In paroxysmal patients presenting for catheter ablation, was measured from surface 12‐lead electrocardiogram. The AERP defined as longest S1–S2 coupling...
Genome wide association studies have identified several single nucleotide polymorphisms (SNPs) associated with atrial fibrillation (AF), but the mechanisms underlying these relationships not yet been elucidated. Inflammation and fibrosis posited as important responsible for AF. We sought to investigate impact of SNP carrier status on inflammation in left appendage tissue.Carrier 10 AF-associated SNPs was evaluated DNA extracted from tissue 176 individuals (120 AF). The presence through...