A5014237411- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Sarcoidosis and Beryllium Toxicity Research
- Congenital heart defects research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA Research and Splicing
- Cardiovascular Syncope and Autonomic Disorders
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Cardiomyopathy and Myosin Studies
- Viral Infections and Immunology Research
- Pluripotent Stem Cells Research
- Cardiac Imaging and Diagnostics
- Receptor Mechanisms and Signaling
- Tissue Engineering and Regenerative Medicine
- Alcohol Consumption and Health Effects
- Vasculitis and related conditions
- Heart rate and cardiovascular health
- MicroRNA in disease regulation
- Cardiac Fibrosis and Remodeling
- Cardiac Structural Anomalies and Repair
- Venous Thromboembolism Diagnosis and Management
University of California, San Francisco
2015-2024
University of Michigan
2022-2024
Virginia Commonwealth University
2022-2024
Gladstone Institutes
2007-2019
Madras Medical Mission
2017
Indiana University – Purdue University Indianapolis
2017
University of Pennsylvania
2014-2017
Icahn School of Medicine at Mount Sinai
2017
Stanford University
2017
Cedars-Sinai Medical Center
2017
Considerable evidence exists to support the hypothesis that hippocampus and related medial temporal lobe structures are crucial for encoding storage of information in long-term memory. Few human imaging studies, however, have successfully shown signal intensity changes these areas during or retrieval. Using functional magnetic resonance (fMRI), we studied normal subjects while they performed a novel picture task. High-speed echo-planar techniques evaluated fMRI throughout brain. During...
Treatment of sinus node disease with regenerative or cell-based therapies will require a detailed understanding gene regulatory networks in cardiac pacemaker cells (PCs).To characterize the transcriptome PCs using RNA sequencing and to identify transcriptional responsible for PC expression.We used laser capture microdissection on reporter mouse line isolate from sequencing. Differential expression network analysis identified novel sinoatrial node-enriched genes predicted that transcription...
Background Long‐term corticosteroid therapy is the standard of care for treatment cardiac sarcoidosis ( CS ). The efficacy long‐term corticosteroid‐sparing immunosuppression in unknown. goal this study was to assess methotrexate with or without adalimumab disease suppression , and recurrence adverse event rates after discontinuation. Methods Results Retrospective chart review identified treatment‐naive patients at a single academic medical center who received maintenance therapy....
BACKGROUND: During the neonatal stage, cardiomyocyte undergoes a constellation of molecular, cytoarchitectural, and functional changes known collectively as maturation to increase myocardial contractility cardiac output. Despite importance maturation, molecular mechanisms governing this critical process remain largely unexplored. METHODS: We leveraged an in vivo mosaic knockout system characterize role Carm1 , founding member protein arginine methyltransferase, maturation. Using battery...
Patients' self-reports suggest that acute alcohol consumption may trigger a discrete atrial fibrillation (AF) event.To objectively ascertain whether heightens risk for an AF episode.A prospective, case-crossover analysis.Ambulatory persons in their natural environments.Consenting patients with paroxysmal AF.Participants were fitted continuous electrocardiogram (ECG) monitor and ankle-worn transdermal ethanol sensor 4 weeks. Real-time documentation of each alcoholic drink consumed was...
Ventricular tachycardia (VT) is associated with high mortality in patients cardiac sarcoidosis (CS), and medical management of CS-associated VT limited by failure rates. The role catheter ablation has been investigated small, single-center studies.To investigate outcomes CS.This cohort study from the Cardiac Sarcoidosis Consortium registry (2003-2019) included 16 tertiary referral centers US, Europe, Asia. A total 158 consecutive CS were (33% female; mean [SD] age, 52 [11] years; 53%...
The isotope shift of the ${2}^{3}{S}_{1}\ensuremath{-}{2}^{3}{P}_{0}$ transition in helium has been measured using laser excitation an atomic beam, yielding 33 668.074(5) MHz. This value, combined with theory and ${}^{4}$He nuclear charge radius, gives a ${}^{3}$He radius 1.9506(14) fm. result is over order magnitude more precise than previous determinations. It agrees two recent theoretical values 1.958(6) 1.954(7) fm from realistic nucleon-nucleon potentials binding energy. Our provides...
Lidocaine produces voltage- and use-dependent inhibition of voltage-gated Na+ channels through preferential binding to channel conformations that are normally populated at depolarized potentials by slowing the rate repriming after depolarizations. It has been proposed fast-inactivation mechanism plays a crucial role in these processes. However, precise fast inactivation lidocaine action difficult probe because gating drug-bound does not involve changes ionic current. For reason, we employed...
Background Transseptal puncture is a critical step in achieving left atrial ( LA ) access for variety of cardiac procedures. Although the mechanical B rockenbrough needle has historically been used this procedure, employing radiofrequency RF energy more recently approved clinical use. We sought to investigate comparative effectiveness an versus conventional transseptal access. Methods and Results In prospective, single‐blinded, controlled trial, 72 patients were randomized 1:1 fashion BRK...
Patients with frequent premature ventricular complexes (PVCs) might be at risk for the developing or exacerbation of left (LV) dysfunction. However, some patients a high-PVC burden do not develop cardiomyopathy, while other low-PVC can cardiomyopathy. The purpose this study was to evaluate positive predictors idiopathic PVCs-induced cardiomyopathy.We investigated 214 undergoing successful ablation PVCs who had no causes We divided cohort into 2 groups: ejection fraction (EF) ≥ 50% (normal...
Idiopathic ventricular arrhythmia (VA) can arise from the epicardium near posteroseptal region (cardiac crux). There are only 2 prior reports describing idiopathic VA cardiac crux. The purpose of this study was to characterize clinical and electrocardiographic features crux VA.Crux identified in 18 patients undergoing catheter ablation. We divided into groups, those with originating apical (n=9) basal (n=9). described characteristics as well ablation results. Furthermore, we compared other...
Cardiac pacemaker cells (PCs) in the sinoatrial node (SAN) have a distinct gene expression program that allows them to fire automatically and initiate heartbeat. Although critical SAN transcription factors, including Isl1 (Islet-1), Tbx3 (T-box factor 3), Shox2 (short-stature homeobox protein 2), been identified, cis-regulatory architecture governs PC-specific is not understood, discrete enhancers required for regulation identified.To define epigenetic profile of PCs using comparative...
GATA4 (GATA-binding protein 4), a zinc finger-containing, DNA-binding transcription factor, is essential for normal cardiac development and homeostasis in mice humans, mutations this gene have been reported human heart defects. Defects alternative splicing are associated with many diseases, yet relatively little known about how cell type- or state-specific achieved the heart. Here, we show that regulates type-specific through direct interaction RNA spliceosome induced pluripotent stem...