Kyla J. Hildebrand
A5074356338- Food Allergy and Anaphylaxis Research
- Immunodeficiency and Autoimmune Disorders
- Asthma and respiratory diseases
- Drug-Induced Adverse Reactions
- Respiratory and Cough-Related Research
- Eosinophilic Esophagitis
- Pharmaceutical studies and practices
- Respiratory viral infections research
- Allergic Rhinitis and Sensitization
- Blood disorders and treatments
- Pediatric health and respiratory diseases
- Immune Cell Function and Interaction
- Pneumonia and Respiratory Infections
- Viral gastroenteritis research and epidemiology
- Immune Response and Inflammation
- Immune responses and vaccinations
- Celiac Disease Research and Management
- Parvovirus B19 Infection Studies
- Contact Dermatitis and Allergies
- Infectious Diseases and Tuberculosis
- Child and Adolescent Health
- RNA modifications and cancer
- Autoimmune and Inflammatory Disorders Research
- Diabetes and associated disorders
- NF-κB Signaling Pathways
British Columbia Children's Hospital
2016-2025
University of British Columbia
2016-2025
Western University
2012-2024
University of Toronto
2010-2024
3M (United States)
2024
Children's Hospital
2024
Public Health Ontario
2024
Community Research and Development Information Service
2023
Canadian Paediatric Society
2019-2021
Child and Family Research Institute
2013-2020
X-linked recessive deficiency of TLR7, a MyD88- and IRAK-4–dependent endosomal ssRNA sensor, impairs SARS-CoV-2 recognition type I IFN production in plasmacytoid dendritic cells (pDCs), thereby underlying hypoxemic COVID-19 pneumonia with high penetrance. We report 22 unvaccinated patients autosomal MyD88 or IRAK-4 infected (mean age: 10.9 yr; 2 mo to 24 yr), originating from 17 kindreds eight countries on three continents. 16 were hospitalized: six moderate, four severe, critical pneumonia,...
Interferon regulatory factor 4 (IRF4) is a transcription (TF) and key regulator of immune cell development function. We report recurrent heterozygous mutation in IRF4, p.T95R, causing an autosomal dominant combined immunodeficiency (CID) seven patients from six unrelated families. The exhibited profound susceptibility to opportunistic infections, notably Pneumocystis jirovecii , presented with agammaglobulinemia. Patients’ B cells showed impaired maturation, decreased immunoglobulin isotype...
Inborn errors of immunity (IEIs) are a group conditions whereby parts the immune system missing or dysfunctional. Once thought to primarily be pediatric disorder, it is now estimated that more than 50% worldwide incident IEI cases accounted for by adults. Delayed diagnosis, late symptom onset, and phenocopies can all lead adult-onset recognition IEIs. Lack awareness regarding diversity manifestations in adults contributes diagnostic treatment delays. Prompt referral immunology critical so...
Background: Age and certain medical/social conditions are risk factors for invasive pneumococcal disease (IPD).For prevention of IPD, the National Advisory Committee on Immunization (NACI) has recommended 23-valent polysaccharide vaccine, PNEU-P-23, adults 65 years age older over 18 living with underlying conditions.NACI also 13-valent conjugate PNEU-C-13, adults; however, in publicly funded programs, this recommendation is limited to individuals IPD.Two new vaccines, PNEU-C-15 PNEU-C-20,...
COVID-19 vaccination has been associated with anaphylaxis and hypersensitivity reactions. Infectious disease physicians allergists in the Canadian Special Immunization Clinic (SIC) Network developed guidance for evaluating patients adverse events following immunization (AEFI) including suspected hypersensitivity. This study evaluated management event recurrence subsequent vaccinations.
By March 2024, 40 cases had been reported (12 in 2023).[1][1] One measles case can cause infection 90% of exposed, unvaccinated people.[2][2] Complications occur 30% cases, most frequently children younger than 5 years; complications include otitis media, pneumonia,
Background Helios (encoded by IKZF2 ), a member of the Ikaros family transcription factors, is zinc finger protein involved in embryogenesis and immune function. Although predominantly recognised for its role development function T lymphocytes, particularly CD4 + regulatory cells (Tregs), expression extends beyond system. During embryogenesis, expressed wide range tissues, making genetic variants that disrupt strong candidates causing widespread immune-related developmental abnormalities...
Inborn errors of immunity (IEIs) are a group conditions affecting immune system development and function. Due to their clinical heterogeneity lack provider awareness, patients suffer from long diagnostic delays that increase morbidity mortality. Next-generation sequencing facilitates earlier diagnosis treatment IEIs, but too often unable see the benefit this technology due gaps in providers' knowledge regarding which test barriers accessing sequencing.Here, we provide detailed phenotyping...