Chaoqun Cui
A5022531812- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Blood disorders and treatments
- Helicobacter pylori-related gastroenterology studies
- Tuberculosis Research and Epidemiology
- Chronic Lymphocytic Leukemia Research
- Ubiquitin and proteasome pathways
- Escherichia coli research studies
- PI3K/AKT/mTOR signaling in cancer
Fudan University
2019-2023
Shanghai Medical College of Fudan University
2019
Interferon regulatory factor 4 (IRF4) is a transcription (TF) and key regulator of immune cell development function. We report recurrent heterozygous mutation in IRF4, p.T95R, causing an autosomal dominant combined immunodeficiency (CID) seven patients from six unrelated families. The exhibited profound susceptibility to opportunistic infections, notably Pneumocystis jirovecii , presented with agammaglobulinemia. Patients’ B cells showed impaired maturation, decreased immunoglobulin isotype...
Significance IgA is the most abundantly produced antibody in body (in humans, >5 g/d) and plays a crucial role mucosal immunity. forms dimer that covalently associates with joining (J) chain, which essential for transport into gut. We show MZB1 required secretion of IgA, but not IgG, by antibody-secreting plasma cells. mediates stabilization Igα heavy-chain–light-chain complexes and, more importantly, promotes J-chain binding to IgA. Mice lacking are impaired secreting large amounts gut...
Elimination of autoreactive developing B cells is an important mechanism to prevent autoantibody production. However, how cell receptor (BCR) signaling triggers apoptosis immature remains poorly understood. We show that BCR stimulation up-regulates the expression lysosomal-associated transmembrane protein 5 (LAPTM5), which in turn through two pathways. LAPTM5 causes internalization, resulting decreased phosphorylation SYK and ERK. In addition, targets E3 ubiquitin ligase WWP2 for lysosomal...
Colorectal cancer (CRC) ranks among the top causes of mortality globally. Gut inflammation is one crucial risk factor that augments CRC development since patients suffering from inflammatory bowel disease have an increased incidence CRC. The role immunoglobulin (Ig)A in maintaining gut homeostasis and preventing has been well established. Our earlier work demonstrated marginal zone B1 cell-specific protein (MZB1) promotes IgA secretion its absence results pronounced dextran sulfate sodium...