Elaine Cheng
A5010707189- Organ Transplantation Techniques and Outcomes
- Clinical Nutrition and Gastroenterology
- Renal Transplantation Outcomes and Treatments
- Obesity, Physical Activity, Diet
- Melanoma and MAPK Pathways
- bioluminescence and chemiluminescence research
- Organ and Tissue Transplantation Research
- Child Nutrition and Feeding Issues
- Viral Infectious Diseases and Gene Expression in Insects
- Liver Disease and Transplantation
- Neuroscience and Neuropharmacology Research
- Nutrition and Health in Aging
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Breastfeeding Practices and Influences
- Alzheimer's disease research and treatments
- Birth, Development, and Health
- Viral gastroenteritis research and epidemiology
- Cancer-related gene regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Regulation of Appetite and Obesity
- Cystic Fibrosis Research Advances
- Acne and Rosacea Treatments and Effects
- Hepatitis B Virus Studies
- Transplantation: Methods and Outcomes
Hong Kong University of Science and Technology
2013-2024
University of Hong Kong
2006-2024
United Christian Hospital
2024
Hong Kong Science and Technology Parks Corporation
2024
Inspira Medical Center Vineland
2023
Health Net
2023
Target (United States)
2022
The University of Sydney
2021
University of California, Los Angeles
2015-2018
Terasaki Foundation
2016-2017
Significance Synaptic loss and dysfunction is associated with cognitive impairment in Alzheimer’s disease (AD). However, the pathophysiological mechanisms underlying synaptic are largely unknown. Here, we reveal a previously unidentified signaling pathway whereby activation of receptor tyrosine kinase EphA4 critical for dysfunctions AD. Proof-of-concept studies undertaken both vitro vivo systems demonstrate its importance mediating deficit transmission hippocampal long-term potentiation AD...
Abstract INTRODUCTION Existing blood‐based biomarkers for Alzheimer's disease (AD) mainly focus on its pathological features. However, studies associated with other biological processes a comprehensive evaluation of AD status are limited. METHODS We developed blood‐based, multiplex biomarker assay that measures the levels 21 proteins involved in multiple pathways. evaluated assay's performance classifying and indicating AD‐related endophenotypes three independent cohorts from Chinese or...
Learning and memory require orchestrated regulation of both structural functional synaptic plasticity in the hippocampus. While a neuropeptide alpha-melanocyte-stimulating hormone, α-MSH, has been implicated acquisition retention, role its cognate receptor, melanocortin-4 receptor (MC4R), hippocampal-dependent not explored. In this study, we report that activation MC4R enhances through dendritic spine morphology abundance AMPA receptors. We show postsynaptic increases number mature spines...
Serum α-fetoprotein (AFP) is a biomarker for hepatocellular carcinomas (HCCs) associated with more aggressive tumor phenotype and inferior outcomes after liver transplant (LT). Data on the patients HCCs that do not produce AFP are limited.To compare characteristics among LT recipients radiographically apparent HCC lesions AFP-producing tumors or (hereafter referred to as non-AFP-producing tumors), identify factors influencing recurrence in tumors.Retrospective analysis at university center...
In Brief Background Rejection remains the leading cause of allograft loss, and a major barrier to improving long-term outcomes after intestinal transplantation. Our aim is define prevalence investigate role donor-specific antibody (DSA) on graft outcomes. Methods The study includes 109 transplants performed in 95 recipients at single center. Patients were screened for DSA pretransplant, monitored regularly posttransplant when clinically indicated using single-antigen bead Luminex assay....
Abstract Post‐transplant lymphoproliferative disease ( PTLD ) has the highest incidence following intestinal transplantation IT x). Our center seen a recent increase in . aim was to review single‐center experience with focus on clinical characteristics and outcomes. We completed retrospective of biopsy‐proven cases using prospectively maintained database 115 x recipients transplanted between 1991 2014. Nineteen (17%) developed 25 during median follow‐up time 6.4 (1.6‐14.6) years. The early...
Background. A major unmet challenge is to reduce the islet mass needed for insulin independence in type 1 diabetic recipients after transplantation. The recombinant homodimer of human annexin V, diannexin, has completed a Phase II Clinical Trial Kidney Transplantation (NCT00615966). Methods. We developed marginal transplantation model (10–12 islets per gram recipient body weight) and investigated whether diannexin prevents β-cell apoptosis improves graft function. Diannexin was administered...
Naturally occurring, thymic-derived Foxp3+CD25+CD4+ regulatory T cells (nTregs) are pivotal for the maintenance of self-tolerance. nTregs, however, sparse and lack alloantigen specificity, these properties pose challenges their use in clinical transplantation.We established mixed leukocyte reaction (MLR) with dendritic (DCs) as stimulators CD4+ responders supplemented MLR IL-2 TGF-β1 investigated whether DCs+IL-2+TGF-β1 differentiate polyclonal into alloantigen-specific allograft protective...
Abstract The significance of post‐transplant HLA DSA and chronic AMR in LT is an emerging field study. Although OPV has previously been described as a histopathologic finding DSA‐positive adult recipients, it was not included the recent Banff criteria for AMR. Our aim to describe association between pediatric recipients. A retrospective review 67 liver biopsies performed November 2014 April 2016 45 recipients identified four patients with OPV. Clinical status, biochemistry, presence DSA,...
Intravenous heparin has traditionally been given during living donor laparoscopic nephrectomy despite the paucity of evidence supporting its use. We present results our experience with done without intraoperative systemic heparinization.We retrospectively reviewed records 167 consecutive nephrectomies intravenous from July 2005 to October 2007 at institution. evaluated preoperative characteristics, and postoperative complications, recipient renal function graft outcomes.All 138 left were...
Introduction: The use of direct-acting antiviral (DAA) agents against chronic hepatitis C virus (HCV) infections can result in the successful treatment nearly all patients. Effective treatments prevent progression to cirrhosis and hepatocellular malignancy, decrease liver-related morbidity mortality.Areas covered: Paritaprevir–ritonavir–ombitasvir dasabuvir (PrOD), with or without ribavirin, is an all-oral regimen approved for HCV genotype 1 infections, including patients compensated...
Overactive bladder (OAB) is a common urological disease with high prevalence in older adult populations.Antimuscarinic drugs have been the most treatment for OAB more than decade, but their anticholinergic side-effects and potential impact on cognitive function among patients are usually underestimated.This consensus aimed to provide practical recommendations concerning management, particular emphasis patients.A joint panel was formed by representatives of Hong Kong Urological Association...