A5089026206- RNA and protein synthesis mechanisms
- Bacteriophages and microbial interactions
- Bacterial Genetics and Biotechnology
- Viral gastroenteritis research and epidemiology
- Escherichia coli research studies
- Carcinogens and Genotoxicity Assessment
- Salmonella and Campylobacter epidemiology
- Genomics and Phylogenetic Studies
- MicroRNA in disease regulation
- ATP Synthase and ATPases Research
- Lipid Membrane Structure and Behavior
- Hepatitis C virus research
- Surgical Simulation and Training
- SARS-CoV-2 and COVID-19 Research
- Extracellular vesicles in disease
- Machine Learning in Bioinformatics
- Enzyme Structure and Function
- Monoclonal and Polyclonal Antibodies Research
- Respiratory viral infections research
- Fungal Plant Pathogen Control
- Cancer Research and Treatments
- Polyomavirus and related diseases
- Vibrio bacteria research studies
- Hepatitis Viruses Studies and Epidemiology
- Biochemical Acid Research Studies
University of Maryland, Baltimore
2020-2023
U-M Rogel Cancer Center
2023
University of North Carolina at Chapel Hill
2013-2016
Institut Pasteur
1980-1998
Hôpitaux Universitaires de Strasbourg
1998
Institut de Recherche contre les Cancers de l’Appareil Digestif
1998
Centre National de la Recherche Scientifique
1980-1996
Salk Institute for Biological Studies
1993
University of Georgia
1992
Centre de Génétique Moléculaire
1992
Highlights•In silico predictions of miR-2392 as a miRNA involved with SARS-CoV-2•Overexpression produces similar biological response COVID-19 infection•miR-2392 is confirmed to circulate in serum and urine patients COVID-19•Development initiated potential antiviral therapeutic against COVID-19SummaryMicroRNAs (miRNAs) are small non-coding RNAs post-transcriptional gene regulation that have major impact on many diseases provide an exciting avenue toward therapeutics. From patient...
Three group of children were immunized with an inactivated Port Chalmers (H3ChN2Ch) influenza vaccine (group A), a neuraminidase-specific (HeqlN2Ch) B), or placebo. Immunization induced seroconversion for H3Chand N2Ch-specific antibody in A and N2Ch B. The protective efficacies observed against naturally acquired illness the strain virus 68.7% 37.4% groups B, respectively, comparison to placebo group, those produced by subsequent outbreak Victoria 80.0% 72.7%. These data support role...
Despite the large interest in simulators of minimally invasive surgery, it is still unclear to what extent can achieve task training medical students surgical procedures. The answer that question certainly linked realism displays and force-feedback systems level interaction provided by computer system.
lamB encodes the lambda receptor of Escherichia coli, an outer membrane protein. We have identified beginning gene by correlating DNA nucleotide sequence with a partial primary translation product lamB. show that is synthesized as precursor containing extra 25 amino acids at its NH2 terminus. These are predominately hydrophobic and probably comprise structure required for initiation transport from cytoplasm to membrane.
For DNA-reactive chemicals, a low dose linear assessment of cancer risk is the science policy default. In present study, we quantitated endogenous and exogenous N7-methyl-G O(6)-methyl-dG adducts in human lymphoblastoid cells exposed to [D3]-methylnitrosourea. Endogenous amounts both remained nearly constant, while showed dose-responses. The data show that ≥1.8/10(8) dG correlated with published studies demonstrated significant increases mutations under these conditions. combined results do...
The reactivity to freeze-thawed mitochondria or submitochondrial particles of a whole antiserum raised against the uncoupling protein has been investigated. Incubation with brown adipose tissue trapped antibodies reactive toward accessible parts protein. One-third one-half which were present in serum remained free. These highly vesicles obtained by sonication mitochondria, matricial side inner membrane was made accessible. To define epitopes recognized antiserum, different fusion proteins up...
Recombinant derivatives of nonpathogenic bacteria such as attenuated Salmonella typhi have the potential to be used for delivery heterologous antigens immune system. Genetic factors may modulate responses these live organisms and could therefore modify immunogenicity future human vaccines. In present study, we compared antibody Ity or H-2 congenic strains mice a foreign antigen expressed by murine aroA S. typhimurium strain. Our results demonstrate that gene but major genetic influence is...
Contamination of potentially carcinogenic hexavalent chromium (Cr(VI)) in the drinking water is a major public health concern worldwide. However, little information available regarding biological effects nanomoler amount Cr(VI). Here, we investigated genotoxic Cr(VI) at levels and their repair pathways. We found that DNA damage response analyzed based on differential toxicity isogenic cells deficient various proteins observed after three-day incubation with K2CrO4 REV1-deficient DT40 19.2...
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Summary MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation that have a major impact on many diseases and provides an exciting avenue towards antiviral therapeutics. From patient transcriptomic data, we discovered circulating miRNA, miR-2392, is directly with SARS-CoV-2 machinery during host infection. Specifically, show miR-2392 key driving downstream suppression of mitochondrial expression, increasing inflammation, glycolysis, hypoxia as well...
Attenuated salmonellae represent an attractive vehicle for the delivery of heterologous protective antigens to immune system. Here, we have investigated influence genetic background host which regulates growth and elimination Salmonella cells on cellular response induced against a foreign antigen delivered by aroA strain. We tested CD4+ T-cell responses (cell proliferation cytokine production) in various mouse strains following immunization with typhimurium SL3261 expressing high level...
Background and Aims Access to basic health needs remains a challenge for most of world’s population. In this study, we developed care model preventive disease‐specific an extremely remote marginalized population in Arunachal Pradesh, the northeasternmost state India. Approach Results We performed patient screenings, interviews, obtained blood samples villages Pradesh through tablet‐based data collection application, which was later synced cloud database storage. Positive cases hepatitis B...