A5078843899- Quantum Dots Synthesis And Properties
- Advanced biosensing and bioanalysis techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Gold and Silver Nanoparticles Synthesis and Applications
- Plasmonic and Surface Plasmon Research
- Molecular Junctions and Nanostructures
- Photonic Crystals and Applications
- Inflammasome and immune disorders
- Biosensors and Analytical Detection
- Nanoplatforms for cancer theranostics
- Carbon and Quantum Dots Applications
- Advanced Photocatalysis Techniques
- TiO2 Photocatalysis and Solar Cells
- Advanced Nanomaterials in Catalysis
- Nanopore and Nanochannel Transport Studies
- Chalcogenide Semiconductor Thin Films
- SARS-CoV-2 and COVID-19 Research
- Optical Coatings and Gratings
- Thermal Radiation and Cooling Technologies
- Immune Response and Inflammation
- Gas Sensing Nanomaterials and Sensors
- Tryptophan and brain disorders
- Nanowire Synthesis and Applications
- Spaceflight effects on biology
- Photoreceptor and optogenetics research
BioWorks (United States)
2021-2024
Activated Research Company (United States)
2023
University of Colorado Boulder
2013-2021
QuantumBio (United States)
2021
University of Colorado System
2013-2020
Biochemical Society
2017
University of Minnesota
2008-2016
Los Alamos National Laboratory
2011-2013
University of Minnesota, Duluth
2010
Perfectly Flat? Plasmonic devices, which exploit the interactions of light with surface electrons, show great promise for applications in sensing, communications, and energy conversion. A key hindrance is deposition patterned metals used plasmonics, because, as deposited, terminal surfaces are rough not amenable to patterning by directional dry-etching techniques. Nagpal et al. (p. 594 ) use silicon substrates on they add gold, silver, or copper then apply an epoxy layer deposited metal....
Colloidal semiconductor nanocrystals have attracted significant interest for applications in solution-processable devices such as light-emitting diodes and solar cells. However, a poor understanding of charge transport nanocrystal assemblies, specifically the relation between electrical conductance dark under light illumination, hinders their technological applicability. Here we simultaneously address issues 'dark' photoconductivity films PbS nanocrystals, by incorporating them into optical...
Inexpensive, reproducible, and high-throughput fabrication of nanometric apertures in metallic films can benefit many applications plasmonics, sensing, spectroscopy, lithography, imaging. Here we use template-stripping to pattern periodic nanohole arrays optically thick, smooth Ag with a silicon template made via nanoimprint lithography. is low-cost material good optical properties, but it suffers from poor chemical stability biocompatibility. However, thin silica shell encapsulating our...
Upconversion of infrared radiation into visible light has been investigated for applications in photovoltaics and biological imaging. However, low conversion efficiency due to small absorption cross-section (Yb(3+)), slow rate energy transfer (to Er(3+) states) prevented application upconversion photoluminescence (UPL) diffuse sunlight or imaging tissue samples. Here, we utilize resonant surface plasmon polaritons (SPP) waves enhance UPL doped-lanthanide nanocrystals. Our analysis indicates...
We demonstrate three-dimensional plasmonic nanofocusing of light with patterned metallic pyramids obtained via template stripping. Gratings on the faces these convert linearly polarized into plasmons that propagate toward and converge at a approximately 10 nm apex. Experiments computer simulations confirm optical energy is focused nanoscale volume (5 x 10(-5) wavelength(3)). Because structures are easily reproducibly fabricated, our results could benefit many applications, including imaging,...
Living cells do not interface naturally with nanoscale materials, although such artificial organisms can have unprecedented multifunctional properties, like wireless activation of enzyme function using electromagnetic stimuli. Realizing interfacing in a nanobiohybrid organism (or nanorg) requires (1) chemical coupling via affinity binding and self-assembly, (2) the energetic between optoelectronic states materials cellular process, (3) design appropriate interfaces ensuring biocompatibility....
A simple route to flat, large-area, single-crystalline films for plasmonics is demonstrated by sputter deposition of silver onto mica substrates at elevated temperatures. The exhibit improved dielectric properties and allow more precise patterning high-quality nanostructures plasmonic applications. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted the authors....
The rise of multidrug-resistant (MDR) bacteria is a growing concern to global health and exacerbated by the lack new antibiotics. To treat already pervasive MDR infections, classes antibiotics or antibiotic adjuvants are needed. Reactive oxygen species (ROS) have been shown play role during antibacterial action; however, it not yet understood whether ROS contribute directly an outcome bacterial lethality caused We show that light-activated nanoparticle, designed produce tunable flux specific...
Highlights•In silico predictions of miR-2392 as a miRNA involved with SARS-CoV-2•Overexpression produces similar biological response COVID-19 infection•miR-2392 is confirmed to circulate in serum and urine patients COVID-19•Development initiated potential antiviral therapeutic against COVID-19SummaryMicroRNAs (miRNAs) are small non-coding RNAs post-transcriptional gene regulation that have major impact on many diseases provide an exciting avenue toward therapeutics. From patient...
Neuroinflammation plays a crucial role in the development of neurodegenerative protein misfolding disorders. This category progressive diseases includes, but is not limited to, Alzheimer's disease, Parkinson's and prion diseases. Shared pathogenesis involves accumulation misfolded proteins, chronic neuroinflammation, synaptic dysfunction, ultimately leading to irreversible neuronal loss, measurable cognitive deficits, death. Presently, there are few no effective treatments halt advancement...
We examine the use of metallic photonic crystals as thermophotovoltaic emitters. coat silica woodpile structures, created using direct laser writing, with tungsten or molybdenum. Optical reflectivity and thermal emission measurements near 650 °C demonstrate that resulting structures should provide efficient emitters at relatively low temperatures. When matched to InGaAsSb photocells, our generate over ten times more power than solid while having an optical-to-electrical conversion efficiency...
Although losses in plasmonic films can be detrimental for optoelectronics, they exploited to create novel thermal emitters. Surface plasmon polaritons that are thermally excited on a heated metal surface converted photons with useful properties. We demonstrate highly tailored emission from tungsten and molybdenum patterned series of circular concentric grooves (i.e., bull's eye). At 900 °C our structures emit an infrared beam normal the film is spectrally narrow (tens nanometers) directional...
We study the structure of electronic states in individual PbS nanocrystal quantum dots by scanning tunneling spectroscopy (STS) using one-to-two monolayer films treated with 1, 2-ethanedithiols (EDT). Up to six valence and conduction band are resolved for a range dot sizes. The measured states' energies good agreement calculations k · p four-band envelope function formalism. A comparison STS optical absorption spectra indicates that some features can only be explained asymmetric transitions...
A rapid increase in anthropogenic emission of greenhouse gases, mainly carbon dioxide, has been a growing cause for concern. While photocatalytic reduction dioxide (CO2) into solar fuels can provide solution, lack insight energetic pathways governing photocatalysis impeded study. Here, we utilize measurements electronic density states (DOS), using scanning tunneling microscopy/spectroscopy (STM/STS), to identify energy levels responsible CO2–water an artificial photosynthetic process. We...
Multiple sclerosis (MS) is a debilitating autoimmune disease that impacts millions of patients worldwide, disproportionately impacting women (4:1), and often presenting at highly productive stages life. This affects the spinal cord brain characterized by severe neuroinflammation, demyelination, subsequent neuronal damage, resulting in symptoms like loss mobility. While untargeted pan-immunosuppressive therapies have proven to be disease-modifying manage (or prolong time between) many...
Abstract Neuroinflammation contributes to impaired cognitive function in brain aging and neurodegenerative disorders like Alzheimer’s disease, which is characterized by the aggregation of pathological tau. One major driver both age- tau-associated neuroinflammation NF-κB NLRP3 signaling axis. However, current treatments targeting or may have adverse/systemic effects, most not been clinically translatable. In this study, we tested efficacy a novel, nucleic acid therapeutic (Nanoligomer)...
Immune malfunction or misrecognition of healthy cells and tissue, termed autoimmune disease, is implicated in more than 80 disease conditions multiple other secondary pathologies. While pan-immunosuppressive therapies like steroids can offer limited relief for systemic inflammation some organs, many patients never achieve remission, such drugs do not cross the blood-brain barrier, making them ineffective tackling neuroinflammation. Especially brain, unintended activation microglia astrocytes...
We conduct measurements of photocharging PbSe and PbS nanocrystal quantum dots (NQDs) as a function excitation energy (ℏω). observe rapid growth the degree with increasing ℏω, which indicates an important role hot-carrier transfer in photoionization process. The corresponding spectral dependence exhibits two thresholds that mark onsets weak strong photocharging. Interestingly, both are linked to NQD band gap (E(g)) scale ∼1.5E(g) ∼3E(g), indicating associated specific states (tentatively, 1P...
We present a novel plasmonic antenna structure, split-wedge antenna, created by splitting an ultrasharp metallic wedge with nanogap perpendicular to its apex. The can tightly confine gap plasmons and boost the local optical field intensity in around these opposing tips. This three-dimensional integrates key features of nanogaps sharp tips, i.e., tight confinement nanofocusing, respectively, into single platform. fabricate antennas gaps that are as small 1 nm width at wafer scale combining...
The devastating effects of the coronavirus disease 2019 (COVID-19) pandemic have made clear a global necessity for antiviral strategies. Most fatalities associated with infection from severe acute respiratory syndrome 2 (SARS-CoV-2) result at least partially uncontrolled host immune response. Here, we use an antisense compound targeting previously identified microRNA (miRNA) linked to cases COVID-19. binds specifically miRNA in question, miR-2392, which is produced by human cells several...
As the world braces to enter its fourth year of coronavirus disease 2019 (COVID-19) pandemic, need for accessible and effective antiviral therapeutics continues be felt globally. The recent surge Omicron variant cases has demonstrated that vaccination prevention alone cannot quell spread highly transmissible variants. A safe nontoxic therapeutic with an adaptable design respond emergence new variants is critical transitioning treatment COVID-19 as endemic disease. Here, we present a novel...
ABSTRACT Multiple Sclerosis (MS) is a debilitating autoimmune disease that impacts millions of patients worldwide, disproportionately impacting women (4:1), and often presenting at highly productive stages life. This affects the spinal cord brain, characterized by severe neuroinflammation, demyelination, subsequent neuronal damage, resulting in symptoms like loss mobility. While untargeted pan-immunosuppressive therapies have proven to be disease-modifying manage (or prolong time between)...