A5079752915- Neuroinflammation and Neurodegeneration Mechanisms
- Barrier Structure and Function Studies
- Alzheimer's disease research and treatments
- COVID-19 Clinical Research Studies
- Human-Animal Interaction Studies
- SARS-CoV-2 and COVID-19 Research
- Neuroscience and Neuropharmacology Research
- Prion Diseases and Protein Misfolding
- Tryptophan and brain disorders
- COVID-19 Impact on Reproduction
- Bacterial Infections and Vaccines
- Inflammasome and immune disorders
- Nerve injury and regeneration
- Neurological diseases and metabolism
- Tuberculosis Research and Epidemiology
- Neurogenesis and neuroplasticity mechanisms
- Long-Term Effects of COVID-19
- Macrophage Migration Inhibitory Factor
- Infectious Diseases and Tuberculosis
- Parkinson's Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Nuclear Receptors and Signaling
Colorado State University
2021-2024
Neuroinflammation plays a crucial role in the development of neurodegenerative protein misfolding disorders. This category progressive diseases includes, but is not limited to, Alzheimer's disease, Parkinson's and prion diseases. Shared pathogenesis involves accumulation misfolded proteins, chronic neuroinflammation, synaptic dysfunction, ultimately leading to irreversible neuronal loss, measurable cognitive deficits, death. Presently, there are few no effective treatments halt advancement...
Mesenchymal stromal cells (MSCs) are an intriguing avenue for the treatment of neurological disorders due to their ability migrate sites neuroinflammation and respond paracrine signaling in those by secreting cytokines, growth factors, other neuromodulators. We potentiated this stimulating MSCs with inflammatory molecules, improving migratory secretory properties. investigated use intranasally delivered adipose-derived (AdMSCs) combating prion disease a mouse model. Prion is rare, lethal...
Despite significant research efforts, treatment options for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain limited. This is due in part to a lack of therapeutics that increase host defense the virus. Replication SARS-CoV-2 lung tissue associated with marked infiltration macrophages and activation innate immune inflammatory responses amplify injury. Antagonists androgen (AR) glucocorticoid (GR) receptors have shown efficacy models COVID-19 clinical studies because cell...
Canine cognitive dysfunction (CCD) syndrome is a well-recognized naturally occurring disease in aged dogs, with remarkably similar course, both its clinical presentation and neuropathological changes, as humans Alzheimer’s (AD). Similar to human AD patients this found the aging canine population however, there little understanding of how brain ages pathologically. It well known that neurodegenerative diseases, an increase inflamed glial cells accumulation hyperphosphorylation tau (P-tau)...
Tuberculosis, caused by Mycobacterium tuberculosis infection, is an ongoing epidemic with estimated ten million active cases of the disease worldwide. Pulmonary associated cognitive and memory deficits, patients this are at increased risk for Parkinson's dementia. Although epidemiological data correlates neurological effects peripheral disease, pathology in central nervous system unknown. In established guinea pig model low-dose, aerosolized we see behavior changes loss infected animals. We...
Abstract Neuroinflammation plays a crucial role in the development of neurodegenerative protein misfolding disorders. This category progressive diseases includes, but is not limited to, Alzheimer’s disease, Parkinson’s and prion diseases. Shared pathogenesis involves accumulation misfolded proteins, chronic neuroinflammation, synaptic dysfunction, ultimately leading to irreversible neuronal loss, measurable cognitive deficits, death. Presently, there are little no effective treatments halt...
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) infection, is a chronic inflammatory disease. Although typically associated with inflammation of the lungs and other peripheral tissues, increasing evidence has uncovered neurological consequences attributable to Mtb infection. These include deficits in memory cognition, increased risk for neurodegenerative disease, progressive neuropathology. effects without CNS have been characterized, mechanism neurotoxicity unknown. We...
Abstract Alzheimer’s Disease and Related Dementias (AD/ADRD) affect an estimated 55 million people worldwide; a staggering figure that is expected to grow in the coming years. With these projections looming, we have yet identify any cures, treatments, or preventative strategies. Historically, AD/ADRD research conducted using genetically engineered model, expresses specific brain aging pathology. Modern research, however, has identified complex dynamic “inflammaging” phenotype exists with...
Abstract Parkinson’s disease (PD) is the most common neurodegenerative movement disorder worldwide. Current treatments for PD largely center around dopamine replacement therapies and fail to prevent progression of pathology, underscoring need neuroprotective interventions. Approaches that target neuroinflammation, which occurs prior dopaminergic neuron (DAn) loss in substantia nigra (SN), represent a promising therapeutic strategy. The glucocorticoid receptor (GR) has been implicated...
Alzheimer's disease (AD) is the most common form of dementia. However, while 150+ animal models AD exist, drug translation from preclinical to humans for treatment usually fails. One factor contributing low likely absence neurodegenerative that also encompass multi-morbidities human aging. We previously demonstrated that, in comparison PigmEnTed (PET) guinea pig strain which "typical" brain aging, Hartley develops hallmarks like aging humans. Hartleys exhibit age-related impairments...
Abstract Since its initial discovery in late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID19, has spread worldwide and despite significant research efforts, treatment options remain limited. Replication SARS-CoV-2 lung is associated with marked infiltration macrophages activation innate immune inflammatory responses triggered, part, by heightened production interleukin-6 (IL-6) that recruits lymphocytes to site infection amplify tissue injury....
Abstract Canine cognitive dysfunction (CCD) syndrome is a well-recognized naturally occurring disease in aged dogs, with remarkably similar course, both its clinical presentation and neuropathological changes, as humans Alzheimer’s (AD). Similar to human AD patients this found the aging canine population however, there little understanding of how brain ages pathologically. It well known that neurodegenerative diseases, an increase inflamed glial cells accumulation hyperphosphorylation tau...