A5032658855- CAR-T cell therapy research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- MicroRNA in disease regulation
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Erythrocyte Function and Pathophysiology
- Extracellular vesicles in disease
- Immune Response and Inflammation
- Phagocytosis and Immune Regulation
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- COVID-19 and healthcare impacts
- Integrated Circuits and Semiconductor Failure Analysis
- Hematopoietic Stem Cell Transplantation
- COVID-19 Impact on Reproduction
- Hematological disorders and diagnostics
- HER2/EGFR in Cancer Research
- PI3K/AKT/mTOR signaling in cancer
- Multiple Myeloma Research and Treatments
- Acute Myeloid Leukemia Research
- Cell Adhesion Molecules Research
- Cancer therapeutics and mechanisms
University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center
2019-2025
University of Maryland, Baltimore
2017-2025
U-M Rogel Cancer Center
2018-2025
South China Normal University
2024
Sidney Kimmel Comprehensive Cancer Center
2023
University of Mary
2019
Affiliated Hospital of Shaanxi University of Chinese Medicine
2008
Lund University
2007
Pennsylvania State University
2004-2007
When cells undergo apoptosis, or programmed cell death, they expose phosphatidylserine (PS) on their surface. Macrophages that efficiently phagocytose apoptotic also express PS surface, although at a lower level. The exposed both is required for phagocytosis, because uptake inhibited by masking either with annexin V, PS-binding protein. inhibition not additive, suggesting the molecules two participate in common process. We asked whether this dual requirement reflects bridging of target and...
Sepsis-associated encephalopathy (SAE) occurs in sepsis survivors and is associated with breakdown of the blood–brain barrier (BBB), brain inflammation, neurological dysfunction. We have previously identified a group extracellular microRNAs (ex-miRNAs), such as miR-146a-5p, that were upregulated plasma septic mice human, capable inducing potent pro-inflammatory cytokines complements. Here, we established clinically relevant mouse model SAE investigated role miRNAs their sensor Toll-like...
Solid organ transplant recipients (SOTR) receiving post-transplant immunosuppression show increased COVID-19-related mortality. It is unclear whether an additional dose of COVID-19 vaccines can overcome the reduced immune responsiveness against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants.We analysed humoral responses SARS-CoV-2 and its variants in 53 SOTR vaccination.Following initial vaccination series, 60.3% showed no measurable neutralisation only 18.9%...
Immune-checkpoint inhibitors (ICIs) are an effective therapeutic strategy, improving the survival of patients with lung cancer compared conventional treatments. However, novel predictive biomarkers needed to stratify which derive clinical benefit because currently used and highly heterogenic histological PD-L1 has shown low accuracy. Liquid biopsy is analysis in body fluids represents a minimally invasive tool that can be monitor tumor evolution treatment effects, potentially reducing biases...
Lymph node (LN) fibroblastic reticular cells (FRCs) define LN niches and regulate lymphocyte homeostasis through producing diverse extracellular matrix (ECM) components. We examined the role of ECM laminin α4 (Lama4) using FRC-Lama4 conditional KO Pdgfrb-Cre-/- × Lama4fl/fl mice. Single-cell RNA-sequencing (scRNA-Seq) data showed promoter gene Pdgfrb was exclusively expressed in FRCs. Depleting reduced Tregs dendritic cells, decreased high endothelial venules, impaired conduit system,...
Abstract Persistence of drug-resistant quiescent leukemic stem cells (LSC) and impaired natural killer (NK) cell immune response account for relapse chronic myelogenous leukemia (CML). Inactivation protein phosphatase 2A (PP2A) is essential CML-quiescent LSC survival NK antitumor activity. Here we show that MIR300 has antiproliferative PP2A-activating functions are dose dependently differentially induced by CCND2/CDK6 SET inhibition, respectively. upregulated in CML LSCs bone marrow...
Abstract Background Aggressive B cell lymphoma with secondary central nervous system (CNS) involvement (SCNSL) carries a dismal prognosis. Chimeric antigen receptor (CAR) T cells (CAR-T) targeting CD19 have revolutionized the treatment for lymphomas; however, only single cases CNS manifestations successfully treated CAR-T been reported. Methods We prospectively enrolled 4 patients SCNSL into our study to assess clinical responses and monitor immunity. Results Two of four SNCSL responded...
Abstract Idecabtagene vicleucel (ide-cel) and ciltacabtagene autoleucel (cilta-cel) are approved chimeric antigen receptor T cell (CAR T) therapies for multiple myeloma. Unfortunately, most patients receiving these treatments will experience toxicities and/or relapse highlighting the need optimizing CAR strategies. We performed first in-depth, comparative prospective biomonitoring of (N=39) cilta-cel or ide-cel in real-world setting. Cilta-cel response rates were higher, although not...
Anti-SARS-CoV-2 antibodies are crucial for protection from future COVID-19 infections, limiting disease severity, and control of viral transmission. While patients with the most common type hematologic malignancy, B cell lymphoma, often develop insufficient antibody responses to messenger RNA (mRNA) vaccines, vaccine-induced T cells would have potential ‘rescue’ protective immunity in lymphoma. Here we report case a patient lymphoma profound depletion after initial chemoimmunotherapy who...
Periodontitis is one of the most common oral diseases in humans, affecting over 40% adult Americans. Pain-sensing nerves, or nociceptors, sense local environmental changes and often contain neuropeptides. Recent studies have suggested that nociceptors magnify host response regulate bone loss periodontium. A subset projected to periodontium contains neuropeptides, such as calcitonin gene-related peptide (CGRP) substance P (SP). However, specific roles neuropeptides from nociceptive neural...
Tangier disease is an inherited disorder that results in a deficiency circulating levels of HDL. Although the known to be caused by mutations ABCA1 gene, mechanism which lesions ATPase effect this outcome not known. The inability knockout mice (ABCA1−/−) load cholesterol and phospholipids onto apoA1 led proposal mediates transbilayer externalization phospholipids, activity integral only formation HDL particles but also another, distinct process: recognition clearance apoptotic cells...
We are seeking to identify molecular targets that relevant breast cancer cells with stem-like properties. There is growing evidence stem (CSCs) supported by inflammatory mediators expressed in the tumor microenvironment. The chemokine receptor CXCR3 binds interferon-γ-inducible, ELR-negative CXC chemokines CXCL9, CXCL10, and CXCL11 malignant have co-opted this promote cell migration invasion. 2 major isoforms of CXCR3: CXCR3A CXCR3B. latter generated from alternative splicing results a...
Periodontitis is a highly prevalent chronic inflammatory disease that progressively destroys the structures supporting teeth, leading to tooth loss. Periodontal tissue innervated by abundant pain-sensing primary afferents expressing neuropeptides and transient receptor potential vanilloid 1 (TRPV1). However, roles of nociceptive nerves in periodontitis bone destruction are controversial. The placement ligature around maxillary second molar or oral inoculation pathogenic bacteria induced...
The ErbB/HER family of protein-tyrosine kinases (ErbB) and the phosphatidylinositol 3-kinase (PI3K) represent crucial targets in treatment head neck squamous cell carcinoma (HNSCC). We previously reported that a combination therapy using Afatinib (ErbB inhibitor) Copanlisib (PI3K inhibitor), both FDA-approved kinase inhibitors, suppressed growth HPV-positive HNSCC. In our current study, we further evaluated efficacy clinical potential this for treating HPV-negative HNSCC vitro animal model....
ABSTRACT Osteoclasts (OCs) are bone-resorbing cells formed by the serial fusion of monocytes. In mice and humans, three distinct subsets monocytes exist; however, it is unclear if all them exhibit osteoclastogenic potential. Here we show that in wild-type (WT) mice, Ly6Chi Ly6Cint primary source OC formation when compared to Ly6C− Their potential dictated increased expression signaling receptors activation preestablished transcripts, as well de novo gain enhancer activity promoter changes....
Post-transplant lymphoproliferative disorder (PTLD) is a potentially fatal complication following kidney transplantation, and there critical unmet need for PTLD treatments associated with more pronounced durable responses. To date, reports on the use of CD19-targeted chimeric antigen receptor (CAR) T (CAR-T) cells in patients after solid organ transplant (SOT) have been anecdotal, clinical presentations outcomes heterogenous, longitudinal analysis CAR-T cell expansion persistence has not...
Abstract In light of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants potentially undermining humoral immunity, it is important to understand the fine specificity antiviral antibodies. We screened 20 COVID-19 patients for antibodies against 9 different SARS-CoV-2 proteins observing responses spike (S) proteins, receptor-binding domain (RBD), and nucleocapsid (N) protein which were IgG1 IgG3 subtypes. Importantly, mutations typically occur in B.1.351 “South African”...
Fibroblastic reticular cells (FRCs) play important roles in tolerance by producing laminin α4 (Lama4) and altering lymph node (LN) structure function. The present study revealed the specific of extracellular matrix Lama4 regulating LN conduits using FRC-specific KO mouse strains. FRC-derived maintained conduit fiber integrity, as its depletion altered morphology reduced homeostatic flow. regulated lymphotoxin β receptor (LTβR) pathway, which is critical for integrity. Depleting LTβR FRCs...
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Abstract Glycophorin A (GPA), a red blood cell (RBC) surface glycoprotein, can maintain peripheral leukocyte quiescence through interaction with sialic acid–binding Ig-like lectin (Siglec-9). Under inflammatory conditions such as sickle disease (SCD), the GPA of RBCs undergo structural changes that affect this interaction. Peripheral samples from patients SCD before and after RBC transfusions were probed for neutrophil monocyte activation markers analyzed by fluorescence-activated sorting...