A5022081533- Pregnancy and preeclampsia studies
- Maternal and Perinatal Health Interventions
- Immune Cell Function and Interaction
- Gestational Diabetes Research and Management
- Acute Myeloid Leukemia Research
- Maternal and fetal healthcare
- Neonatal and fetal brain pathology
- Prenatal Screening and Diagnostics
- Birth, Development, and Health
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Preterm Birth and Chorioamnionitis
- Phagocytosis and Immune Regulation
- Extracellular vesicles in disease
- Ectopic Pregnancy Diagnosis and Management
- Space Satellite Systems and Control
- Pancreatitis Pathology and Treatment
- Astronomical Observations and Instrumentation
- Anesthesia and Pain Management
- Osteoarthritis Treatment and Mechanisms
- Assisted Reproductive Technology and Twin Pregnancy
- Sperm and Testicular Function
- Neonatal Respiratory Health Research
- Cell Adhesion Molecules Research
- Cytokine Signaling Pathways and Interactions
Medical College of Wisconsin
2022-2023
University of Dayton
2022
University of Maryland, Baltimore
2014-2020
University of Mary
2019
University of Maryland Medical Center
2015-2018
Loyola University Chicago
2015
St. Vincent's University Hospital
1976
Abstract Persistence of drug-resistant quiescent leukemic stem cells (LSC) and impaired natural killer (NK) cell immune response account for relapse chronic myelogenous leukemia (CML). Inactivation protein phosphatase 2A (PP2A) is essential CML-quiescent LSC survival NK antitumor activity. Here we show that MIR300 has antiproliferative PP2A-activating functions are dose dependently differentially induced by CCND2/CDK6 SET inhibition, respectively. upregulated in CML LSCs bone marrow...
Automated monitoring of low resolution, deep-space objects in wide field view (WFOV) imaging systems can benefit from the improved performance deep learning object detectors. The PANDORA sensor array, located Maui at Air Force Optical and Supercomputing Site, is an exemplar a scalable architecture that detect dim while maintaining WFOV. system captures 20°×120° images night sky oriented along GEO belt rate two frames per minute. Prior work has established baseline for detection...
<h3></h3> Persistence of drug-resistant quiescent leukemic stem cells (LSC) and impaired natural killer (NK) cell immune response account for relapse chronic myelogenous leukemia (CML). Inactivation protein phosphatase 2A (PP2A) is essential CML-quiescent LSC survival NK antitumor activity. Here we show that <i>MIR300</i> has antiproliferative PP2A-activating functions are dose dependently differentially induced by CCND2/CDK6 SET inhibition, respectively. upregulated in CML LSCs bone marrow...
INTRODUCTION: Obesity and associated morbidity significantly impacts obstetric management, including increased indication for induction of labor (IOL). Retrospective studies report obesity prolonging course. We aim to investigate duration IOL stratified by body mass index (BMI). hypothesize prolongs IOL. METHODS: Prospective cohort study singletons undergoing Obstetric management was per provider's discretion (vaginal misoprostol, cervical balloon, intravenous oxytocin). The primary outcome...
Abstract Inhibition of protein phosphatase 2A (PP2A) tumor suppressor is essential for chronic myelogenous leukemia (CML) stem cell (LSC) maintenance and disease development. Persistence drug-resistant quiescent LSCs depends on cell-autonomous bone marrow (BM) signals. Herein, we identified miR-300 as an miRNA inhibited in CD34+ CML progenitors during blastic transformation (BC) through the BCR-ABL1-dependent inhibition C/EBPβ-induced transcription. In progenitors, ectopic mir-300 expression...
ABSTRACT Drug-resistance of tumor-initiating cells, impaired NK cell immune-response, PP2A loss-of-function and aberrant miRNA expression are cancer features resulting from microenvironmental- tumor-specific signals. Here we report that genomic-imprinted MIR300 is a context-independent dual function tumor suppressor which upregulated in quiescent leukemic stem (LSC) cells by microenvironmental signals to induce quiescence impair respectively, but inhibited CML AML proliferating blasts...
Hemimegalencephaly (HME) is a rare neurological diagnosis defined as hamartomatous overgrowth of one cerebral hemisphere. The hypothesised pathogenesis due to an increased number or size neural cells; however, the exact mechanism can vary widely, depending on underlying aetiology. We report case outlining prenatal diagnostic process and obstetric considerations for delivering infant with HME secondary megalencephaly–capillary malformation syndrome. After diagnosis, our patient was induced...