A5055826104- Chronic Myeloid Leukemia Treatments
- Cancer-related Molecular Pathways
- Chronic Lymphocytic Leukemia Research
- RNA Interference and Gene Delivery
- Schizophrenia research and treatment
- Estrogen and related hormone effects
- Monoclonal and Polyclonal Antibodies Research
- Click Chemistry and Applications
- Virus-based gene therapy research
- Cancer Research and Treatments
- Acute Lymphoblastic Leukemia research
- Cell death mechanisms and regulation
- Nuclear Structure and Function
- RNA Research and Splicing
- PI3K/AKT/mTOR signaling in cancer
- Ubiquitin and proteasome pathways
- Vaccine Coverage and Hesitancy
- Viral Infectious Diseases and Gene Expression in Insects
- CAR-T cell therapy research
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Eosinophilic Disorders and Syndromes
- Electroconvulsive Therapy Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Mental Health and Psychiatry
University of Utah
2014-2024
Harvard University
2010-2024
Massachusetts General Hospital
2021-2024
Tufts University
2024
New Hampshire Hospital
2021
Dartmouth–Hitchcock Medical Center
2021
The University of Texas MD Anderson Cancer Center
2014-2020
Bucheon St. Mary's Hospital
2020
Catholic University of Korea
2020
Interfaith Medical Center
2017
While the peptide and protein therapeutic market has developed significantly in past decades, delivery limited their use. Although oral is preferred, most are currently delivered intravenously or subcutaneously due to degradation absorption gastrointestinal tract. Therefore, enhancers, enzyme inhibitors, carrier systems stability enhancers being studied facilitate delivery. Additionally, transdermal avoids issues of tract, but also faces limitations. Due proteases, opsonization...
Abstract Initiation of pancreatic ductal adenocarcinoma (PDAC) is driven by oncogenic KRAS mutation, and disease progression associated with frequent loss tumor suppressors. In this study, human PDAC genome analyses revealed deletion the PTEN gene as well expression in primary specimens. A potential role for a haploinsufficient suppressor further supported mouse genetic studies. The Kras mutation Pten deficiency also sustains spontaneous extinction Ink4a shows prometastatic capacity....
Abstract Subcellular localization and transcriptional activity of green fluorescent protein-progesterone receptor A B chimeras (GFP-PRA GFP-PRB) were examined in living mammalian cells. Both GFP-PRA found to be similar compared with their non-GFP counterparts. PRA both weakly active, while GFP-PRB PRB gave a 20- 40-fold induction using reporter gene containing the full-length mouse mammary tumor virus long-terminal repeat linked luciferase (pLTRluc). Using fluorescence microscopy,...
Glioblastoma multiforme (GBM) is the most common and lethal primary brain cancer that driven by aberrant signaling of growth factor receptors, particularly epidermal receptor (EGFR). EGFR tightly regulated endocytosis lysosome-mediated degradation, although molecular mechanisms governing such regulation, in context cancer, remain poorly delineated. Here, high-resolution genomic profiles GBM identified a highly recurrent focal 1p36 deletion encompassing putative tumor suppressor gene, Mig-6....
T cells expressing chimeric antigen receptors (CARs) have shown remarkable therapeutic activity against different types of cancer. However, the wider use CAR has been hindered by potential for life-threatening toxicities due to on-target off-tumor killing low amounts target antigen. CD229, a signaling lymphocyte-activation molecule (SLAM) family member, previously identified as cell–mediated treatment multiple myeloma (MM) its high expression on surfaces MM cells. CD229 effective clearance...
The glucocorticoid receptor interacting protein-1 (GRIP1) is a member of the steroid coactivator (SRC) family transcriptional regulators. Green fluorescent protein (GFP) fusions were made to full-length GRIP1, and series GRIP1 mutants lacking defined regulatory regions intracellular distribution these proteins was studied in HeLa cells. complex, ranging from diffuse nucleoplasmic discrete intranuclear foci. Formation foci dependent on C-terminal region which contains two characterized...
Abstract The application of thiol–yne/thiol–ene reactions to synthesize mono‐ and bicyclic‐stapled peptides proteins is reported. First, a thiol–ene‐based peptide‐stapling method in aqueous conditions was developed. This enabled the efficient stapling recombinantly expressed coil‐coiled proteins. resulting stapled protein demonstrated higher stability its secondary structure than unstapled version. Furthermore, thiol–yne coupling performed by using an α,ω‐diyne react with two cysteine...
This pilot project aimed to maximize COVID-19 vaccine uptake among patients with serious mental illness. Psychiatric providers were engaged directly address vaccine-related concerns during outpatient visits.A quality improvement encouraged vaccinations in a cohort of outpatients treated clozapine (N=193, ages 19-81 years, mean age=46.4 years) at community health center. In-service education was provided clinicians identify vaccine-hesitant and build confidence. A vaccination-monitoring tool...
Alzheimer's disease (AD) and Schizophrenia (SCZ) exhibit overlapping clinical features biological mechanisms, but the extent of their shared genetic etiology potential for cross-disorder risk prediction are not fully elucidated, with previous studies yielding mixed results. This study investigated whether integrating statistically-selected SCZ-associated single nucleotide polymorphisms (SNPs), identified from large-scale GWAS, could enhance machine learning (ML)-based AD beyond models using...
Targeting the tumor suppressor p53 to mitochondria triggers a rapid apoptotic response as efficiently transcription-dependent p53. (1, 2) forms complex with antiapoptotic Bcl-XL, which leads Bak and Bax oligomerization resulting in apoptosis via mitochondrial outer membrane permeabilization. (3, 4) Although performs its main role membrane, it also interacts different proteins inner matrix. (5, 6) To further investigate activity of p53, EGFP-p53 was fused targeting signals (MTSs) directing...
Oligomerization is an important regulatory mechanism for many proteins, including oncoproteins and other pathogenic proteins. The oncoprotein Bcr-Abl relies on oligomerization via its coiled coil domain kinase activity, suggesting that a designed with enhanced binding to reduced self-oligomerization would be therapeutically useful. Key mutations in the of were identified reduce homo-oligomerization through intermolecular charge-charge repulsion yet increase interaction additional salt...