A5045360442- Cancer Cells and Metastasis
- Microtubule and mitosis dynamics
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Escherichia coli research studies
- Cellular transport and secretion
- Immunotherapy and Immune Responses
- Inorganic Fluorides and Related Compounds
- CAR-T cell therapy research
- Melanoma and MAPK Pathways
- Cellular Mechanics and Interactions
- Protein Structure and Dynamics
- Vibrio bacteria research studies
- Ammonia Synthesis and Nitrogen Reduction
- PI3K/AKT/mTOR signaling in cancer
- Bioinformatics and Genomic Networks
- Gene Regulatory Network Analysis
- Silk-based biomaterials and applications
- Viral gastroenteritis research and epidemiology
- Developmental Biology and Gene Regulation
- Microbial Community Ecology and Physiology
- Hippo pathway signaling and YAP/TAZ
- Congenital limb and hand anomalies
- Molecular Biology Techniques and Applications
- Nanoplatforms for cancer theranostics
Institut National de la Recherche Scientifique
2022-2024
Cegep de Saint Hyacinthe
2023
Université de Montréal
2020-2023
Sonata (United States)
2023
Institute for Research in Immunology and Cancer
2020-2021
Harvard University
2017-2021
Inzen Therapeutics (United States)
2021
Jawaharlal Nehru University
2017
Harvard Stem Cell Institute
2016
Dana-Farber Cancer Institute
2011
Glioblastoma multiforme (GBM) is the most common and lethal primary brain cancer that driven by aberrant signaling of growth factor receptors, particularly epidermal receptor (EGFR). EGFR tightly regulated endocytosis lysosome-mediated degradation, although molecular mechanisms governing such regulation, in context cancer, remain poorly delineated. Here, high-resolution genomic profiles GBM identified a highly recurrent focal 1p36 deletion encompassing putative tumor suppressor gene, Mig-6....
Abstract KIF14 is a mitotic kinesin whose malfunction associated with cerebral and renal developmental defects several cancers. Like other kinesins, couples ATP hydrolysis microtubule binding to the generation of mechanical work, but coupling mechanism between these processes still not fully clear. Here we report 20 high-resolution (2.7–3.9 Å) cryo-electron microscopy KIF14-microtubule structures complementary functional assays. Analysis procedures were implemented separate coexisting...
ABSTRACT Amputation of a salamander limb triggers regeneration process that is perfect. A limited number genes have been studied in this context and even fewer analyzed functionally. In work, we use the BMP signaling inhibitor LDN193189 on Ambystoma mexicanum to explore role BMPs regeneration. We find required for proper expression various patterning its inhibition causes major defects regenerated limbs. Fgf8 downregulated when blocked, but ectopic injection either human or axolotl protein...
In Escherichia coli , the disaccharide trehalose can be metabolized as a carbon source or accumulated an osmoprotectant under osmotic stress. hypertonic environments, E. accumulates in cell by synthesis from glucose mediated cytosolic enzymes OtsA and OtsB. Trehalose periplasm hydrolyzed into periplasmic trehalase TreA. We have previously shown that treA mutant of extraintestinal strain BEN2908 displayed increased resistance to stress 0.6 M urea, reduced production type 1 fimbriae, invasion...
Abstract Cell-cell adhesion is central to morphogenesis and maintenance of epithelial cell state. We previously identified 27 candidate cell-cell regulatory proteins (CCARPs) whose down-regulation disrupts during collective migration. Using a protein interaction mapping strategy, we found that 18 CCARPs link core components adherens junctions or desmosomes. further mapped linkages between the other known proteins, including hits from recent screens uncovering novel E-cadherin adhesions....
Fimbrial adhesins promote bacterial adherence and biofilm formation. Sequencing of avian pathogenic Escherichia coli (APEC) strain QT598 identified new fimbriae belonging to the π group, which we named PL (P-like) since genetic organization sequence are similar those P related fimbriae. Genes encoding located on IncF plasmids present in diverse E. isolates from poultry, human systemic infections, other sources. As with fimbriae, exhibit divergence adhesin-encoding genes could be divided into...
<h3>Background</h3> Despite considerable advances in cancer immunotherapy, it has proven difficult to effectively target 'cold' tumors with limited immune infiltration. Chimeric antigen receptor T cells (CAR-T cells) are one potential solution; however, their clinical use been confined treating hematologic malignancies partly due physical exclusion the context of solid tumors. Cytokine-based therapy shown significant pre-clinical models, yet its utility marked by efficacy and toxicities....
<h3>Background</h3> Despite considerable progress in immunotherapy, the challenge persists effectively targeting immunologically 'cold' tumors. Cytokine-driven therapy has exhibited promise; however, its integration into clinical practice been hindered by modest efficacy and adverse effects. Moreover, this strategy is not cytotoxic, limiting antigen availability for uptake presentation immune system. Limited studies have evaluated methods enhancing expression release of intrinsic...
Abstract Tumors evolve through progressive accumulation of (epi)genetic alterations, favoring expansion the fittest cell populations as a result stimuli and selective pressures in microenvironment. Intratumor heterogeneity interplay tumor cells with microenvironment present an order complexity that can have profound effects on progression drug sensitivity. While has been described at many levels, there is poor understanding extent functional within single tumor, dynamics spatial organization...
ABSTRACT Reconstruction of biological networks for topological analyses helps in correlation identification between various types biomarkers. These have been vital components System Biology present era. Genes are the basic physical and structural unit heredity. act as instructions to make molecules called proteins. Alterations normal sequence these genes root cause diseases cancer is prominent example disease caused by gene alteration or mutation. slight alterations can be detected...
Abstract KIF14 is a mitotic kinesin protein important for cytokinesis. Its overexpression associated with variety of cancers and mutations in result cerebral renal development defects. Like other kinesins, contains highly conserved catalytic motor domain where the energy from ATP hydrolysis converted to directed movement along microtubules. Although much known regarding molecular mechanism motility, there lack structural information kinesin-microtubule interactions at sufficient resolution...