A5002278529- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Histone Deacetylase Inhibitors Research
- Viral-associated cancers and disorders
- Childhood Cancer Survivors' Quality of Life
- CNS Lymphoma Diagnosis and Treatment
- Integrated Circuits and Semiconductor Failure Analysis
- Multiple and Secondary Primary Cancers
- Epigenetics and DNA Methylation
- Psychotherapy Techniques and Applications
- Nanowire Synthesis and Applications
- Virus-based gene therapy research
- Health Systems, Economic Evaluations, Quality of Life
- Hematological disorders and diagnostics
- Economic and Financial Impacts of Cancer
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Counseling Practices and Supervision
University of Maryland, Baltimore
2020-2025
University of Maryland Medical Center
2020-2025
U-M Rogel Cancer Center
2021-2024
Abstract Background Aggressive B cell lymphoma with secondary central nervous system (CNS) involvement (SCNSL) carries a dismal prognosis. Chimeric antigen receptor (CAR) T cells (CAR-T) targeting CD19 have revolutionized the treatment for lymphomas; however, only single cases CNS manifestations successfully treated CAR-T been reported. Methods We prospectively enrolled 4 patients SCNSL into our study to assess clinical responses and monitor immunity. Results Two of four SNCSL responded...
There is a deficiency of real-world data on the impact combining venetoclax (VEN) with hypomethylating agents (HMAs) in newly diagnosed acute myeloid leukemia (AML) patients. We conducted single-center, propensity-adjusted retrospective cohort study to compare composite complete remission (CCR) rates, median overall survival (m-OS) and event-free (m-EFS). A total 170 adult AML patients were treated first-line azacitidine (AZA) or decitabine (DEC) +/- VEN. Median age was 71 years 99 (58%)...
Post-transplant lymphoproliferative disorder (PTLD) is a potentially fatal complication following kidney transplantation, and there critical unmet need for PTLD treatments associated with more pronounced durable responses. To date, reports on the use of CD19-targeted chimeric antigen receptor (CAR) T (CAR-T) cells in patients after solid organ transplant (SOT) have been anecdotal, clinical presentations outcomes heterogenous, longitudinal analysis CAR-T cell expansion persistence has not...
Acute myeloid leukemia (AML) is the common type of acute in adults. Definitive prognostic significance variants unknown lacks for many commonly mutated genes, including isocitrate dehydrogenase 1 (IDH1) synonymous single nucleotide polymorphism (SNP) variant c.315C>T. In this retrospective cohort study 248 AML patients at University Maryland Greenebaum Comprehensive Cancer Center, we show that IDH1 c.315C>T SNP, previously reported to be associated with poor prognosis by other studies...
The prognostic significance of the length internal tandem duplication (ITD) insertions in mutant FLT3 genes acute myeloid leukemia (AML) is controversial. We conducted a retrospective study to evaluate correlation between ITD base-pair (bp) insertion and clinical outcomes. mutational status gene was evaluated 402 467 consecutive AML patients treated at University Maryland Greenebaum Comprehensive Cancer Center 2013 2020; 77 had FLT3-ITD mutations. Patients were divided into three cohorts...
Several theorists (Bandura, 1969; Hackney & Goodyear, 1984; Searles, 1955) suggest parallels between the relationship in supervision and therapy. We examined supervisor therapist trainee ratings of supervisory working alliance (SWA) 1 week predicting client-rated therapeutic (TWA) therapy session evaluation (TSE) following as well TWA TSE SWA week. Our data included 663 weeks nested within 28 trainees 15 supervisors, disaggregated into differences trainees. At between-supervisor level, when...