A5015240821- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Congenital Anomalies and Fetal Surgery
- Gallbladder and Bile Duct Disorders
- Clinical Nutrition and Gastroenterology
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Central Venous Catheters and Hemodialysis
- Intestinal Malrotation and Obstruction Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metabolism and Genetic Disorders
- Gastrointestinal disorders and treatments
- Abdominal vascular conditions and treatments
- Gastroesophageal reflux and treatments
- Drug Transport and Resistance Mechanisms
- Liver physiology and pathology
- Neonatal Health and Biochemistry
- Transplantation: Methods and Outcomes
- Pancreatic and Hepatic Oncology Research
- Genetic and Kidney Cyst Diseases
- Congenital Diaphragmatic Hernia Studies
- Abdominal Trauma and Injuries
Lurie Children's Hospital
2016-2025
Northwestern University
2015-2024
King's College Hospital
2024
Hospital Nossa Senhora da Conceição
2021
Loyola University Medical Center
2020
British Association of Urological Surgeons
2019
Northwestern Memorial Hospital
2003-2018
657 Oslo
2016
RELX Group (Netherlands)
2015
Tel Aviv University
2015
Primary nonfunction following orthotopic liver transplantation is characterized by rapidly rising serum transaminases, minimal bile production, and severe coagulopathy, which can progress to hypoglycemia, hepatic encephalopathy, acute renal failure. Untreated it has a mortality of over 80% date the only treatment been retransplantation. As result beneficial effect Prostaglandin E1 infusion in patients with fulminant failure, this trial was conducted determine whether PGE1 would be value...
Complications of portal hypertension in children lead to significant morbidity and are a leading indication for consideration liver transplantation. Approaches the management sequelae well described adults evidence-based approaches have been summarized numerous meta-analyses conferences. In contrast, there is paucity data guide complications children. An international panel experts was convened on April 8, 2011 at The Children's Hospital Pittsburgh UPMC review adapt recent report Baveno V...
In Brief Objective: The goals of this study were to describe the clinical and anatomic features infants undergoing Kasai portoenterostomy (KPE) for biliary atresia (BA) examine associations between these parameters outcomes. Methods: Infants enrolled in prospective Childhood Liver Disease Research Education Network, who underwent KPE studied. Patients a blinded, interventional trial excluded from survival analysis. Primary endpoints successful surgical drainage (total bilirubin less than 2...
The recent introduction of the meso Rex bypass raises a possible paradigm shift in therapeutic approach to extra-hepatic portal vein obstruction (EHPVO). Long-term follow-up patients with EHPVO has revealed variety complications including variceal hemorrhage, hypersplenism, biliopathy, growth/development retardation and neuropsychiatric disease. restores physiologic blood flow liver. Thus, when feasible, should be considered clinically significant manifestations EHPVO. opinions panel experts...
The goal of this study was to determine the effectiveness mesenteric vein left portal bypass operation (MLPVB) in correcting extrahepatic thrombosis (EHPVT) children. treatment idiopathic EHPVT has been primarily palliative, whereas MLPVB restores hepatic flow patients with EHPVT.Thirty-four children symptomatic underwent surgery intent perform and were followed for up 7 years. successful 31 (91%), all whom maintain patent grafts have relief follow-up. All had complete from gastrointestinal...
Liver transplantation is increasingly advocated as primary surgical therapy for children with hepatoblastoma involving 3 or 4 sectors of the liver after neoadjuvant chemotherapy. This study evaluated results nontransplant hepatectomy in who might otherwise have been considered transplantation.All underwent resection at a single institution from 1998 to 2009 POST-TEXT IV centrally located III chemotherapy were reviewed.Fourteen (7 boys) median age 8 months diagnosis met criteria. Pulmonary...
To evaluate the efficacy of nontransplant surgery for pediatric cholestasis, 58 clinically diagnosed children, including 20 with Alagille syndrome (ALGS), 16 familial intrahepatic cholestasis‐1 (FIC1), 18 bile salt export pump (BSEP) disease, and 4 others low γ‐glutamyl transpeptidase disease (levels <100 U/L), were identified across 14 Childhood Liver Disease Research Network (ChiLDReN) centers. Data collected retrospectively from individuals who collectively had 39 partial external...
After organ transplant, patients are at risk of posttransplant lymphoproliferative disorders (PTLD). The purpose this study was to analyze 26 pediatric cases PTLD observed our institution between 1988 and 1996, evaluate the validity Society for Hematopathology Workshop (SHPW) 1997 classification in patient population.Charts were reviewed analysis incidence, clinical course, outcome. Tissue samples classified by a pathologist according SHPW recommendations.By morphology, 20 monomorphic, 5...
Children with primary extrahepatic portal vein thrombosis (EHPVT) have portal-systemic shunting, which may lead to disturbed neurocognitive function similar encephalopathy (PSE) seen chronic liver disease and cirrhosis. The functions most affected are those involving fluid cognitive ability, comprise domains such as attention, processing speed, short-term memory, that particularly vulnerable systemic illness or diffuse neurologic insult. We determined the ability of children EHPVT whether...