A5053470126- Congenital Diaphragmatic Hernia Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Esophageal and GI Pathology
- Hernia repair and management
- Gallbladder and Bile Duct Disorders
- Congenital Anomalies and Fetal Surgery
- Pleural and Pulmonary Diseases
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Gastroesophageal reflux and treatments
- Effects and risks of endocrine disrupting chemicals
- Intestinal Malrotation and Obstruction Disorders
- Airway Management and Intubation Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Toxic Organic Pollutants Impact
- Per- and polyfluoroalkyl substances research
- Drug Transport and Resistance Mechanisms
- Urological Disorders and Treatments
- Pancreatitis Pathology and Treatment
- Stress Responses and Cortisol
- Abdominal Trauma and Injuries
- Foreign Body Medical Cases
- Neuroendocrine regulation and behavior
- Gastrointestinal motility and disorders
- Fetal and Pediatric Neurological Disorders
Emory University
2015-2024
Children's Healthcare of Atlanta
2013-2023
Research Triangle Park Foundation
2011-2023
Environmental Protection Agency
2011-2023
University of Miami
2021
The University of Texas Southwestern Medical Center
2021
Southwestern Medical Center
2021
Beaumont Hospital, Royal Oak
2016
HXI (United States)
2014
Clifton Hospital
2014
Per- and polyfluoroalkyl substances (PFAS) are a diverse set of commercial chemicals widely detected in humans the environment. However, only limited number PFAS associated with epidemiological or experimental data for hazard identification. To provide developmental neurotoxicity (DNT) information, work herein employed DNT new approach methods (NAMs) to generate
Since the 2001 U.S. federally mandated phase-out of residential uses organophosphates (OPs), use and potential for human exposure to pyrethroids in indoor environment has increased. We report concentrations common pyrethroids, pyrethroid metabolites, chlorpyrifos floor wipes, urinary metabolites 3,5,6-trichloro-2-pyridinol (TCPy) samples collected 2007-2009 from 90 northern California families as part Study Use Products Exposure Related Behavior (SUPERB). Correlation regression analyses...
To evaluate the efficacy of nontransplant surgery for pediatric cholestasis, 58 clinically diagnosed children, including 20 with Alagille syndrome (ALGS), 16 familial intrahepatic cholestasis‐1 (FIC1), 18 bile salt export pump (BSEP) disease, and 4 others low γ‐glutamyl transpeptidase disease (levels <100 U/L), were identified across 14 Childhood Liver Disease Research Network (ChiLDReN) centers. Data collected retrospectively from individuals who collectively had 39 partial external...
Limited published information exists on young children's exposures to bisphenol A (BPA) in the United States using urinary biomonitoring. In a previous project, we quantified aggregate of 257 preschool children BPA environmental and personal media over 48-h periods 2000–2001 at homes daycares North Carolina Ohio. present study for 81 Ohio ages 23–64 months, total (free conjugated) concentrations these same 2001. Then, examined quantitative relationships between intakes doses through dietary...
Bisphenol A (BPA) is commonly manufactured to make polycarbonate plastics and epoxy resins for use in consumer products packaged goods. BPA has been found several different types of environmental media (e.g., food, dust, air). Many cross-sectional studies have frequently detected concentrations adult urine samples. However, limited data are available on the temporal variability important predictors urinary adults. In this work, major objectives were to: 1) quantify levels duplicate-diet...
Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in many household items. Given concerns over their potential adverse health effects, we identified predictors and evaluated temporal changes of PBDE serum concentrations. concentrations were measured young children (2-8 years old; N = 67), parents (<55 90), older adults (≥55 59) California, with concurrent floor wipe samples collected participants’ homes 2008-2009. We also one year later a subset (N 19) 42). significantly...
Foregut duplications are rare entities that include both esophageal and bronchogenic cysts. The diagnosis of foregut duplication cyst is made most often from an incidental finding on chest radiograph, or due to respiratory compromise mass effect infection. Treatment consists complete resection. Recurrences associated with incomplete Six cases cysts presented were resected thoracoscopically.From May 1998 April 2003, six patients underwent thoracoscopy for resection cyst. One patient required...
To evaluate the ability of a tumor-head volume ratio to predict outcome and incidence hydrops in fetuses with sacrococcygeal teratoma.Seventy-one sonograms were reviewed retrospectively from 28 teratoma managed our institution. Head (HV) total tumor calculated sonograms. Amount cystic was estimated determine solid (STV) for STV/HV ratio.Twenty percent <1 97.3% >1 associated 1 or more abnormal sonographic signs (p = 0.000). Overall mortality 11/27 (41%). There no <1, while 11/18 (61%) died...
Urocortins (UCNs) and their receptors are potent immunoregulators in the gastrointestinal (GI) tract, where they can exert both pro- anti-inflammatory effects. We examined contribution of Ucn1 its to pathogenesis, progression, resolution colitis. Trinitrobenzene sulfonic acid was used induce colitis rats. mRNA immunoreactivity (IR) were ubiquitously expressed throughout GI tract under basal conditions. During colitis, levels fell below on day 1 then increased again by 6, association with an...
Mandates for improved patient safety and increasing work hour restrictions have resulted in changes surgical education. Educational courses increasingly must meet those needs. We sought to determine the experience, skill level, impact of simulation-based education (SBE) on two cohorts pediatric surgery trainees.After Institutional Review Board (IRB) exempt determination, a retrospective review was performed evaluations an annual advanced minimally invasive (MIS) course over 2 consecutive...
Fetal urinary tract obstruction with oligohydramnios produces pulmonary hypoplasia and renal dysplasia. Decompression of the obstructed may restore amniotic fluid allow lung growth, but transabdominal catheter shunt decompression is often inadequate does not for cycling bladder, while open procedures cause significant maternal morbidity. Disruption anatomic obstruction, usually posterior urethral valves in a male fetus, would be ideal has proven technically difficult. Here we describe new...
Calcitonin gene-related peptide (CGRP) mediates neurogenic inflammation and modulates intestinal motility. The CGRP receptor is a heterodimer of calcitonin receptor-like (CLR) receptor-associated modifying protein 1. We used RNA interference to elucidate the specific role CLR in colonic motility inflammation. Intramural injection double-stranded (dsRNA) against (dsCLR) into wall at two sites caused spatial temporal downregulation colon within 1 day dsRNA injection. Knockdown persisted for...