A5009596887- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Neuroblastoma Research and Treatments
- Venous Thromboembolism Diagnosis and Management
- Peripheral Artery Disease Management
- Cancer, Hypoxia, and Metabolism
- Gastroesophageal reflux and treatments
- Liver Diseases and Immunity
- Eosinophilic Esophagitis
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Vascular Procedures and Complications
- Transplantation: Methods and Outcomes
- Molecular Biology Techniques and Applications
- Intracranial Aneurysms: Treatment and Complications
- Cancer therapeutics and mechanisms
- Nutrition and Health in Aging
- Lubricants and Their Additives
- Bariatric Surgery and Outcomes
- Colorectal Cancer Screening and Detection
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Glioma Diagnosis and Treatment
- Diagnosis and Treatment of Venous Diseases
Virginia Commonwealth University
2021-2024
May Institute
2023
Fundación Juan March
2023
University of California, San Diego
1989-2020
UC San Diego Health System
2019
University of Strathclyde
2012
The discovery of somatic Jak2 mutations in patients with chronic myeloproliferative neoplasms has led to significant interest discovering selective inhibitors for use treating these disorders. A high-throughput screening effort identified the pyrazolo[1,5-a]pyrimidine scaffold as a potent inhibitor Jak2. Optimization lead compounds 7a-b and 8 this chemical series activity against Jak2, selectivity other Jak family kinases, good vivo pharmacokinetic properties 7j. In SET2 xenograft model that...
Regorafenib is an inhibitor of multiple kinases with aberrant expression and activity in neuroblastoma tumours that have potential roles pathogenesis.
Timely initiation of rectal cancer treatment improves outcomes, and standard care is to receive definitive within 60 days diagnosis. A retrospective review patients (2013-2023) at a tertiary center was performed. Statistical analysis conducted on stratified time-to-treatment patient sociodemographics. 182/342 (53.2 %) had ≤60 days. Unified significantly faster than fragmented (57.5 vs 77.4 days, p = 0.002). Factors associated with >60 days: sex (p 0.03), age 0.004), insurance 0.006),...
Impact of type 2 diabetes mellitus (T2DM) in patients with end-stage liver disease (ESLD) awaiting transplantation (LT) remains poorly defined. The objective the present study is to evaluate relationship between T2DM and clinical outcomes among LT waitlist registrants. We hypothesize that presence will be associated worse outcomes.
// Sean M. Flynn 1 , Jacqueline Lesperance 2 Andrew Macias Nikki Phanhthilath Megan Rose Paul 3 Jong Wook Kim 4 Pablo Tamayo and Peter E. Zage Department of Surgery, University California San Diego, La Jolla, CA, USA Pediatrics, Division Hematology-Oncology, Peckham Center for Cancer Blood Disorders, Rady Children's Hospital, Medicine, Moores Center, Correspondence to: Zage, email: pzage@ucsd.edu Keywords: neuroblastoma; RXDX-105; CEP-32496; RET; BRAF Received: June 26, 2019 Accepted:...
Abstract Cardiovascular disease (CVD) is an important cause of mortality among liver transplantation (LT) recipients; however, the data on CVD risk stratification following LT are limited. Thus, primary aim this study was to evaluate association between decline in renal function early after and atherosclerotic events. This retrospective included all patients receiving 2007 2019. Early quantified as estimated glomerular filtration rate (GFR) 6 months LT. The endpoint for a composite...
Background. Loss of skeletal muscle can be accompanied by an increase in adipose tissue leading to sarcopenic obesity. There are limited data on how liver transplantation (LT) might impact compartments, particularly among patients with metabolically active disease, such as nonalcoholic steatohepatitis (NASH) and subsequent metabolic sequela. Methods. Skeletal muscle, visceral (VAT), subcutaneous (SAT) were measured using cross-sectional imaging performed 190 pre-LT, 6 mo post-LT 12 post-LT....
Abstract Background and aims: Impact of type 2 diabetes mellitus (T2DM) in patients with decompensated cirrhosis awaiting liver transplantation (LT) remains poorly defined. The current study hypothesizes, that the presence T2DM will be associated worse LT waitlist outcomes include greater burden portal hypertension related complications, hospitalizations, mortality. Methods: In this retrospective study, 593 evaluated for between 1/2010 to 1/2017 were included analysis. impact on...
Background and Objectives Carnoy's fixation compression represents a novel technique to enhance lymph node evaluation accuracy of staging after colorectal cancer resection. Methods This study was performed in all adults undergoing operations by Kaiser Permanente surgeons at two separate facilities. Patients were assigned either location based upon surgeon patient availability. One group patients had their nodes examined with current standard manual (MT). The other specimens fixed solution...
Abstract Neuroblastoma is the most common extracranial solid tumor of childhood. Despite aggressive treatment, outcomes in patients with high-risk disease remains poor and new therapeutics are needed to address their needs. Rearranged during Transfection (RET) a tyrosine kinase that known oncogenic driver multiple human tumors. RET expressed on neural crest derived cells, including neuroblastoma has been shown play role proliferation survival as well. Recent studies have inhibition be...
Introduction: Cardiovascular disease (CVD) is an important cause of long-term mortality in liver transplant (LT) recipients. There are currently no CVD risk-stratification tools that have been validated LT This underscores a significant limitation within clinical hepatology. Thus, we aimed to evaluate Framingham Risk Score (FRS) recipients using adjudicated atherosclerotic events. Methods: Patients receiving between 1/2007 1/2019 (N=553) were included. who died 12 months excluded. Baseline...