A5029983746- Neuroblastoma Research and Treatments
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Acute Lymphoblastic Leukemia research
- Cancer, Hypoxia, and Metabolism
- Astronomy and Astrophysical Research
- Peptidase Inhibition and Analysis
- Galaxies: Formation, Evolution, Phenomena
- Microtubule and mitosis dynamics
- Chronic Lymphocytic Leukemia Research
- Hedgehog Signaling Pathway Studies
- Signaling Pathways in Disease
- Cosmology and Gravitation Theories
- Chronic Myeloid Leukemia Treatments
- History and Developments in Astronomy
- Neuropeptides and Animal Physiology
- Radio Astronomy Observations and Technology
- Retinoids in leukemia and cellular processes
- Stellar, planetary, and galactic studies
- Glycosylation and Glycoproteins Research
- Pharmaceutical studies and practices
- Hemoglobin structure and function
- Ubiquitin and proteasome pathways
- Antimicrobial Peptides and Activities
- Cancer-related Molecular Pathways
Queen Mary University of London
2023
Tata Medical Center
2017-2022
University Children's Hospital Zurich
2022
University of Manchester
2017-2021
Vanderbilt University Medical Center
2010-2018
University College London
2017
Cancer Research UK Manchester Institute
2017
Advanced Centre for Treatment, Research and Education in Cancer
2017
Nashville Oncology Associates
2013
Vanderbilt University
2012
The development of new antibiotics is increasing importance due to the growing resistance power microbes against conventional drugs. To this end, cationic peptides are emerging as clinically potent antimicrobial agents. In present study, we have synthesized six dipeptide-based amphiphiles with different head group structures by varying combinations l-amino acid residues. These showed remarkable growth inhibiting activity on several Gram-positive (minimum inhibitory concentration (MIC)=0.1-10...
// Sora Lee 1,2 , Jingbo Qiao 1 Pritha Paul Kathleen L. O'Connor 3,4 B. Mark Evers Dai H. Chung Departments of Pediatric Surgery, Vanderbilt University Medical Center1, Nashville, TN 2 Cancer Biology, 3 Department Kentucky, Lexington, KY 4 Markey Center, Correspondence: Chung, email: Keywords : GRP-R, FAK, malignant transformation, metastasis, neuroblastoma Received November 01, 2012, Accepted 14, Published 16, 2012 Abstract Neuroblastomas express increased levels gastrin-releasing peptide...
Neuroblastoma is characterized by florid vascularization leading to rapid tumor dissemination distant organs; angiogenesis contributes progression and poor clinical outcomes. We have previously demonstrated an increased expression of gastrin-releasing peptide (GRP) its receptor, GRPR, in neuroblastoma that GRP activates the PI3K-AKT pathway as a proangiogenic factor during progression. Interestingly, AKT activation phosphorylates MTOR, critical negative regulator autophagy, cellular process...
Abstract We examine the computation of wide-angle corrections to galaxy power spectrum including redshift-space distortions and relativistic Doppler corrections, also multiple tracers with differing clustering, magnification evolution biases. show that inclusion contribution, as well radial derivative terms, are crucial for a consistent expansion large-scale surveys, both in single multi-tracer cases. give first time cross-power associated magnification-galaxy cross correlation, which has...
Activation of PI3K/AKT pathway correlates with poor prognosis in patients neuroblastoma. Our previous studies have demonstrated that signaling is critical for the oncogenic transformations induced by gastrin-releasing peptide (GRP) and its receptor, GRP-R, Moreover, PI3K/AKT-dependent require N-myc, an extensively studied oncogene Whether AKT directly regulates expression N-myc yet to be determined. Here, we report a novel finding three isoforms, AKT2 specifically regulated neuroblastoma...
Abstract Galaxy surveys contain information on the largest scales via wide-angle and relativistic contributions. By combining two different galaxy populations, we can suppress strong cosmic variance ultra-large thus enhance detectability of signals. The Doppler Sachs-Wolfe effects are a similar magnitude to leading corrections, so that it is important treat them together, especially since they partially cancel. power spectra depend choice line sight for each pair present results general...
Abstract Background The biotherapeutic asparaginase is a cornerstone of therapy in acute lymphoblastic leukaemia (ALL). With limited access to the original native Escherichia coli ‐derived (EcASNase), variety EcASNase biogenerics are used low‐middle‐income countries (LMICs). variable quality these potentially influences clinical outcomes. Procedure Seven biogeneric EcASNases (P1–P7) marketed widely India were evaluated, with P2 as an exemplar for vivo monitoring. Therapeutic activity (10,000...
Background/Aim: Sirtuins (SIRTs) play crucial roles in various signaling pathways that modulate differentiation and proliferation. We sought to elucidate the role of SIRTs proliferation human neuroblastoma (NB). Materials Methods: NB cells were treated with nicotinamide (NAM), a non-specific SIRT inhibitor, SIRT-targeted short hairpin RNAs, retinoic acid assess cell growth differentiation. Results: are involved using NAM BE(2)-C cells. Specifically, SIRT6 knockdown reduced proliferation,...
Activation of the Hedgehog (Hh) signaling pathway has been implicated in a variety malignancies including neuroblastoma. Expression Gli1, downstream effector Hh, correlates with favorable prognosis patients Moreover, Gli1 overexpression reduces mitotic index and induces transcription genes involved differentiation neuroblastoma cells; however, much remains unknown regarding regulation transcriptional activity. Here, we report novel negative activity by PI3K/AKT2 signal transduction pathway....
Galaxy surveys contain information on the largest scales via wide-angle and relativistic contributions. By combining two different galaxy populations, we can suppress strong cosmic variance ultra-large thus enhance detectability of signals. The Doppler Sachs-Wolfe effects are a similar magnitude to leading corrections, so that it is important treat them together, especially since they partially cancel. power spectra depend choice line sight for each pair present results general sight. Then...
Approximately two-thirds of patients with neuroblastoma are found to have metastatic disease at time diagnosis frequent skeletal, lymph node, central nervous system, and liver involvement. Using a serial in vivo splenic injection model, we isolated an aggressive subclone (BE(2)-C/LM2) from MYCN-amplified neuroblastomas that demonstrate enhanced propensity develop lesions. BE(2)-C/LM2 cells increased adherent, soft agar colony tumorsphere growth vitro. Components the tumor microenvironment...
We have previously demonstrated the role of gastrin-releasing peptide (GRP) as an autocrine growth factor for neuroblastoma. Here, we report that GRP silencing regulates cell signaling involved in invasion-metastasis cascade. Using a doxycycline inducible system, demonstrate decreased anchorage-independent growth, inhibited migration and neuroblastoma cell-mediated angiogenesis vitro, suppressed metastasis vivo. Targeted inhibition mRNA levels oncogenes responsible progression. also...
Recent measurements of the 4-point correlation function in large-scale galaxy surveys have found apparent evidence parity violation distribution galaxies. This cannot happen via dynamical gravitational effects general relativity. If such a arose from physics early Universe it could indicate important new beyond standard model, and would be at odds with most models inflation. It is therefore now timely to consider trispectrum more detail. While intrinsic function, or equivalently trispectrum,...
Recently the galaxy matter density 4-point correlation function has been looked at to investigate parity violation in large scale structure surveys. The is lowest order statistic which sensitive violation, since a tetrahedron simplest shape that cannot be superimposed on its mirror image by rotation. If intrinsic nature, this could give us window into inflationary physics. However, we need exhaust all other contaminations before consider them intrinsic. Even though standard Newtonian...