A5058282525- Cardiac Health and Mental Health
- Neuroblastoma Research and Treatments
- Cardiovascular Health and Risk Factors
- Heart Failure Treatment and Management
- Nutritional Studies and Diet
- Nutrition and Health in Aging
- Lung Cancer Research Studies
- Health and Wellbeing Research
- Palliative Care and End-of-Life Issues
- PI3K/AKT/mTOR signaling in cancer
- Diabetes Management and Education
- Cell death mechanisms and regulation
- Chronic Disease Management Strategies
- Neuroinflammation and Neurodegeneration Mechanisms
- Psychosocial Factors Impacting Youth
- Food Security and Health in Diverse Populations
- Diverse Approaches in Healthcare and Education Studies
- Neuroendocrine Tumor Research Advances
- Cardiac Arrest and Resuscitation
- Geriatric Care and Nursing Homes
- Peptidase Inhibition and Analysis
- NF-κB Signaling Pathways
- Cancer therapeutics and mechanisms
- Homelessness and Social Issues
- Mindfulness and Compassion Interventions
University of Kentucky
2014-2025
Hanyang University Medical Center
2023
Gachon University
2023
Mercer University
2023
Charleston Southern University
2023
Daekyeung University
2023
National Research Foundation of Korea
2023
Gachon University Gil Medical Center
2023
Hanyang University
2023
Chonnam National University
2023
Colorectal cancer is the second leading cause of cancer-related deaths in United States. Understanding distinct genetic and epigenetic changes contributing to establishment growth metastatic lesions crucial for development novel therapeutic strategies. In a search key regulators colorectal metastasis establishment, we have found that serine/threonine kinase Akt2, known proto-oncogene, highly expressed late-stage tumors. Suppression Akt2 expression carcinoma cells inhibits their ability...
The PTEN (phosphatase and tensin homolog deleted on chromosome ten) tumor suppressor gene affects multiple cellular processes including cell growth, proliferation, migration by antagonizing phosphatidylinositol 3-kinase (PI3K). However, mechanisms which expression is regulated have not been studied extensively. Similar to PTEN, necrosis factor-alpha (TNF-alpha) a wide spectrum of diseases inflammatory cancer acting as mediator apoptosis, inflammation, immunity. In this study, we show that...
Abstract The inflammasome is a multimolecular complex that orchestrates the activation of proinflammatory caspases and interleukin (IL)‐1β, which generally increased in cerebrospinal fluids patients with tuberculous meningitis. However, it has not been clarified whether mycobacteria can activate induce IL‐1β maturation microglia. In this study, we found priming primary murine microglial cells conditioned media from cultures macrophages infected Mycobacterium tuberculosis (Mtb) led to robust...
Neuroblastoma accounts for nearly 15% of all pediatric cancer-related deaths. We have previously shown that gastrin-releasing peptide (GRP) stimulates neuroblastoma growth, and its cell surface receptor, GRP-R, is overexpressed in advanced-stage human neuroblastomas; however, the effects GRP/GRP-R on tumorigenesis metastasis vivo are not clearly elucidated. In present study, we found GRP-R knockdown aggressive line BE(2)-C induced morphology changes, reduced size, decreased proliferation,...
Charcot-Marie-Tooth disease (CMT) is the most common inherited peripheral neuropathy and a genetically clinically heterogeneous disorder. We examined Korean family in which two individuals had an autosomal-dominant axonal CMT with early-onset, sensory ataxia, tremor, slow progression. Pedigree analysis exome sequencing identified de novo missense mutation (p.Y223H) diacylglycerol O-acyltransferase 2 (DGAT2) gene. DGAT2 encodes endoplasmic reticulum-mitochondrial-associated membrane protein,...
Background: Exacerbation of heart failure (HF) requires early intervention to prevent hospital admission and reduce mortality. Early care seeking that patients perceive symptoms, accurately evaluate perceived respond appropriately. How perception, evaluation, response symptoms are associated with delay in for worsening has rarely been studied. Objective: The aims this study were investigate the associations perception evaluation delayed HF identify factors seeking. Methods: Patients admitted...
The social determinants of health (SDOH) have been recognized as an important contributor to individual's status. A valid and reliable instrument is needed for researchers clinicians measure SDOH. However, there considerable variability in the screening methodologies, well a lack standardization definitions methods capturing reporting SDOH data both electronic record software vendors national experts on Protocol Responding Assessing Patient Assets, Risks, Experiences (PRAPARE) commonly used...
Abstract Background Cognitive impairment and limited health literacy are prevalent among patients with heart failure, particularly those residing in rural areas, linked to poor outcomes. Little is known about the intricate relationships cognitive function, literacy, rehospitalization death failure. Objectives To determine cardiac event‐free survival (ie, failure hospitalizations mortality) Methods This was a secondary data analysis of randomized controlled trial 573 function measured using...
Introduction This feature highlights the contributions and achievements within American Heart Association/American Stroke Association (AHA/ASA) Council on Cardiovascular Nursing (CVSN) that were announced during AHA/ASA 2024 Scientific Sessions 100th anniversary held in Chicago, IL, November 15 through 18. We also provide details to 2027 CVSN Strategic Plan upcoming 2025 AHA conferences. Award Winners Individuals who made significant research, clinical practice, service improve health of...
Abstract Background: Depressive symptoms, anxiety, and inadequate social support are predictors of health-related quality life (HRQoL) in persons with heart failure, but the prediction HRQoL is multifaceted, mechanisms underlying association unknown. Self-care maintenance may moderate associations among these predictors, which essential to better failure outcomes. Objectives: To determine whether self-care moderates direct indirect effects on through psychological status (i.e., depressive...
Microglial activation induced by beta-amyloid (A beta) is an important cellular response in the pathogenesis of Alzheimer's disease (AD). In this study, we show that reactive oxygen species (ROS) play a role as signaling molecules for NF-kappaB and induction IL-1beta mRNA expression A beta(25-35)-treated murine microglia BV-2 cells. ROS scavengers such catalase superoxide dismutase (SOD) mimetics obviously reduced elevated level transcripts beta(25-35). addition, beta(25-35)-induced were...
Abstract Background Family caregivers are at higher risk for developing cardiovascular disease (CVD) than non‐caregivers. This is worse those who live in rural compared to urban areas. Health activation, an indicator of engagement self‐care, predictive health outcomes and CVD several populations. However, it not known whether activation associated with patients chronic illnesses nor clear sex moderates any association. Objectives Our aims were determine (1) independently predicts 10‐year...
Neuroblastomas are the most common extracranial solid tumors of childhood. These associated with an overall poor prognosis, particularly for advanced stage disease. The benzoquinone ansamycin antibiotic, geldanamycin (GA), exhibits potent antitumor activity in certain cancer cell lines by destabilizing important signal transduction proteins (e.g., Raf-1 and Akt). purpose our study was to determine whether GA can alter expression Akt, which have been shown be critical neuronal survival,...
The purpose of this study was to identify the quality life and its predictors in low income Korean aged.This a predictive correlational study. An accessible sample from population people who were 65 over supported by basic livelihood security system 1,040. Quota sampling with strata state division nation chosen. Quality subjects measured.The mean 47.0+/-10.7. Predictors significantly explained 54.3% total variance life. Depression most significant predictor Health problems, district, social...
Traumatic spinal cord injury (SCI) is followed by massive infiltration and activation of myeloid cells such as neutrophils macrophages, but the functions these are controversial. In this study, our objective was to elucidate in vivo role a signaling pathway involved innate immune SCI using cell-specific IκB kinase (IKK)-β conditional knockout (ikkβΔmye) mice. mice, ikkβ gene has been specifically deleted from cells, compromising their IKK/NF-κB-dependent activation. We found that ikkβΔmye...
Background Health-related quality of life (HRQoL) is poor in patients with heart failure. Psychological (ie, depressive symptoms [DS], anxiety, and perceived control) physical functional status) factors are associated HRQoL. The dynamic relationships among these variables their impact on HRQoL remain unclear, limiting the ability to design effective interventions. Purpose Our aim was evaluate a moderated mediation model, which association between control hypothesized be mediated by DS...
Abstract Background Older adults experiencing homelessness (OAEH) age quickly and die earlier than their housed counterparts. Illness-related decisions are best guided by patients’ values, but healthcare service providers need support in facilitating these discussions. The Serious Illness Conversation Guide (SICG) is a communication tool to guide discussions has not yet been adapted for OAEH. Methods We aimed adapt the SICG use with OAEH nurses, social workers, other providers. conducted...